“…In addition to these detectors, tandem mass spectrometry coupled to HPLC is a robust option to determine the catecholamine content in real samples, as the mass spectrometry (MS) detector has a high selectivity that allows analytes and matrix interferents to be distinguished based on their masses (Lefeuvre et al, 2021). Extraction protocols used in these methods vary from solid‐phase extraction (SPE) on a cation‐exchange column (Takezawa et al, 2000), C 18 cartridges (Talwar et al, 2002) and aluminum oxide columns (He et al, 1997; Li et al, 2000) to liquid–liquid extraction (Dikunets et al, 2020). A different approach than separation‐based methods is batch methods, such as enzyme‐linked immunosorbent assay (ELISA), which have lower selectivity but offer a sensitive, fast and easy‐to‐perform analysis of catecholamines (Kim et al, 2008).…”