Simultaneous Pulmonary Leiomyosarcoma and Leiomyoma in Pediatric HIV Infection

Sabatino, Dominick; Martínez, Santiago; Young, Rosemarie; Balbi, Howard; Ciminera, Peter; Frieri, Marianne

doi:10.3109/08880019109028809

Cited by 26 publications

(10 citation statements)

References 8 publications

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“…Fifty leiomyomas were reported in HIV-infected individuals [9, 60, 70, 73–75, 153–182] or transplant recipients [183–192], of which 80% were in HIV-infected individuals. Among HIV-infected people, 93% of leiomyomas occurred after an AIDS diagnosis.…”

Section: Sarcomas In Immunodeficiencymentioning

confidence: 99%

Sarcomas other than Kaposi sarcoma occurring in immunodeficiency

Bhatia

Shiels

Berg

et al. 2012

Current Opinion in Oncology

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Section: Sarcomas In Immunodeficiencymentioning

confidence: 99%

Sarcomas other than Kaposi sarcoma occurring in immunodeficiency

Bhatia

Shiels

Berg

et al. 2012

Current Opinion in Oncology

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“…However, there are increasing numbers of reports of benign and malignant smooth muscle tumors in younger HIV-infected individuals as well as occasional occurrences in immunosuppressed transplant patients. 9,[11][12][13][14][15] Therefore, we can expect more cases of hepatic leiomyosarcoma to be diagnosed by FNA biopsy.…”

mentioning

confidence: 99%

Fine‐needle aspiration cytology of hepatic leiomyosarcoma

Smith

Silverman

Raab

et al. 1994

Diagnostic Cytopathology

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Hepatic leiomyosarcoma is a rare malignancy to involve the liver, occurring as a primary liver sarcoma in patients without an underlying medical disorder, as a metastatic malignancy, and with increasing incidence, as a primary tumor in AIDS patients. A series of hepatic leiomyosarcomas diagnosed by FNA biopsy, including the first reported case in an adult AIDS patient, were reviewed with respect to cytomorphologic features. The series consisted of five men and two women ranging from 24 to 72 years of age. One case was a primary hepatic lesion in a 24-yr-old man with AIDS and six were metastatic from a number of sites (stomach, small bowel, retroperitoneum, vena cava, and seminal vesicle). Two cytologic patterns were identified. Aspirates of spindle-cell leiomyosarcomas (six cases) generally produced hypocellular smears composed primarily of small irregular clusters of cells with blunt-ended, uniform, overlapping nuclei. The differential diagnosis included benign reactive processes and other benign and malignant spindle-cell neoplasms. The aspirate of an epithelioid leiomyosarcoma (one case) revealed a second pattern characterized by highly cellular smears with many single polygonal cells having eccentric, malignant nuclei and a characteristic clear quality to the cytoplasm in Papanicolaou-stained material. This epithelial appearance generated a differential diagnosis that included hepatocellular carcinoma, metastatic carcinoma, and melanoma. Careful integration of clinical information, cytomorphologic features, and ancillary studies will allow specific FNA diagnosis of hepatic leiomyosarcoma in most cases.

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“…2 The third reported patient had a bronchoscopic biopsy, followed 2 weeks later by ''laser surgery/bronchoscopy'' with uncertain results. 3 The patient is said to have been treated with ''pulmonary exercises'' for persistent atelectasis and eventually succumbed to an episode of cardiorespiratory arrest. Some hepatic, adrenal, and subdural leiomyomas have been resected with good results.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, bronchopulmonary involvement has been documented in only three patients, some of whom were reported on more than one occasion. [2][3][4] Wheezing was mentioned in the clinical summary of one patient. 3,4 The purpose of this report is to describe two additional patients with AIDS-related bronchopulmonary leiomyomas who presented with recent onset of wheezing, thus underscoring the diagnostic clinical significance of this symptom in young patients with AIDS, even in the absence of nodular lesions on the chest radiographs.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] Wheezing was mentioned in the clinical summary of one patient. 3,4 The purpose of this report is to describe two additional patients with AIDS-related bronchopulmonary leiomyomas who presented with recent onset of wheezing, thus underscoring the diagnostic clinical significance of this symptom in young patients with AIDS, even in the absence of nodular lesions on the chest radiographs. In addition, the two patients had splenic involvement with a leiomyoma, an observation that to our knowledge has not been previously reported; they also had EBER demonstrated in their tumor tissue, providing further evidence to support the contention that EBV may play an active role in the development of these tumors.…”

Section: Introductionmentioning

confidence: 99%

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