Simultaneous presentation of acute monoblastic leukemia and mantle cell lymphoma: Case report and review of the literature

Abstract

This paper reports a 73-year old woman with simultaneous presentation of acute monoblastic leukemia (acute myeloid leukemia (AML), French-American-British (FAB) type M5a) and mantle cell lymphoma. The patient presented with wasting, generalized lymphadenopathy, an extensive infiltrative rash and pancytopenia. Bone marrow and lymph node histopatholology showed extensive infiltration by leukemic monoblasts. Marrow cytogenetics revealed a complex karyotype, including t(8;16)(p11;p13). Flow cytometric immunophenotyping of peripheral blood, lymph node and bone marrow demonstrated two populations, expressing CD5, CD19, CD20 and CD22 and CD45, HLA-DR, CD13, CD33, CD14 and CD38, respectively. A focus of abnormal lymphocytes in the lymph node biopsy demonstrated BCL1 expression and t(11;14)(p11;p13) by fluorescence in situ hybridization and immunoglobulin heavy chain gene rearrangement by the polymerase chain reaction. The patient received infusional cytarabine, daunorubicin and etoposide chemotherapy, with complete remission of both the AML and the mantle cell leukemia. To the authors' knowledge, this is the first report of simultaneous presentations of AML, FAB M5a and mantle cell lymphoma. The case is discussed and the literature is reviewed.

Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma: A Case Report and Review of the Literature

“…The unusual simultaneous association of an AML and MCL has been previously described in a single case report [25], and the AML (an acute monoblastic leukemia) was secondary to prior chemotherapy for breast carcinoma. Hsieh et al described a second case where a temporal connection between the two diseases is noted in a 52-year-old male patient who developed AML 3 years after chemotherapy for his MCL.…”

Multiple primary tumor of hematopoietic tissue: myeloid sarcoma in combination with mantle cell lymphoma. Case report

“…Изучая сообщения о синхронном течении МС и лимфопролиферативных заболеваний, нам удалось найти в литературе 3 случая. Одно из наблюдений представлено синхронной диагностикой острого монобластного лейкоза и ЛКМЗ, протекающих с поражением ЛУ и КМ [27]. Пациент успешно получил 2 индукционных и 1 консолидирующий курс терапии цитарабином, даунорубицином и этопозидом, что привело к достижению полной ремиссии по двум новообразованиям на весь период наблюдения, который составил 8 мес.…”