Simultaneous preparation of tritiated uracil and uridine

Radiochemistry

“…The two copper isotopes can be isolated from all the rest by two-stage ion chromatography. Other methods for producing 19 these two isotopes utilise the following reactions, [ 68 Zn(d,x) 67 Cu], [ 66 Zn(p,2pn) 64 Cu] and [ 68 Zn(p,x) 64 Cu], but radiogallium contaminants still have to be removed. The yields of the interfering isotopes that are formed when zinc, enriched with 64 Zn for the production of 64 Cu, is deuteron (19.5 MeV) irradiated, have been reported.…”

“…Other methods for producing 19 these two isotopes utilise the following reactions, [ 68 Zn(d,x) 67 Cu], [ 66 Zn(p,2pn) 64 Cu] and [ 68 Zn(p,x) 64 Cu], but radiogallium contaminants still have to be removed. The yields of the interfering isotopes that are formed when zinc, enriched with 64 Zn for the production of 64 Cu, is deuteron (19.5 MeV) irradiated, have been reported. 20 Reactor neutrons can also initiate the formation 21 of copper-64 from zinc-64, [ 64 Zn(n,p) 64 Cu].…”

“…The yields of the interfering isotopes that are formed when zinc, enriched with 64 Zn for the production of 64 Cu, is deuteron (19.5 MeV) irradiated, have been reported. 20 Reactor neutrons can also initiate the formation 21 of copper-64 from zinc-64, [ 64 Zn(n,p) 64 Cu].…”

“…The replacement of halogens by tritium produces site-specific labelling and can be used to give high specific activity, dopamine, 62 fluorenone and fluorenol 63 as well as uracil and uridine. 64 Other ways of introducing tritium are catalytic reduction of double bonds (short peptides 65 and an antagonist of a corticotropin-releasing hormone 66 ) and the reduction of carbonyl groups using Na[B 3 H 4 ]. This reagent has been used in the preparation of labelled arachidonic acid, 67 [3a-3 H]5a-androst-16-en-3b-ol 68 and silymarin.…”