Simultaneous Pneumatosis Cystoides Intestinalis and Pneumomediastinum in a Patient with Systemic Sclerosis

Honne, Kyoko; Maruyama, Akihito; Onishi, Sachiko; Nagashima, Takao; Minota, Seiji

doi:10.3899/jrheum.100254

Cited by 16 publications

(18 citation statements)

References 9 publications

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“…These case reports describe four spontaneous pneumomediastinum cases, one of which developed after pulmonary function testing 6. Four patients presented with acute onset of dyspnoea and one case report described an asymptomatic patient with pneuomediastinum noted on imaging 7. We report the first presentation of pneumomediastinum in scleroderma presenting as subacute dyspnoea.…”

Section: Discussionmentioning

confidence: 86%

Spontaneous pneumomediastinum in limited cutaneous systemic sclerosis and myositis overlap

Dein

Lee

Timlin³

et al. 2018

BMJ Case Reports

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Section: Discussionmentioning

confidence: 86%

Spontaneous pneumomediastinum in limited cutaneous systemic sclerosis and myositis overlap

Dein

Lee

Timlin³

et al. 2018

BMJ Case Reports

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“…Typical CT findings are submucosal and subserosal air within the bowel wall and free air [ 25 , 26 ]. Like in our patient, PI is sometimes accompanied by pneumomediastinum, which occurs when retroperitoneal and peritoneal air enters along the para-aortic tissues and exits thorough the esophageal hiatus into the mediastinum [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 91%

Gefitinib successfully administered in a lung cancer patient with leptomeningeal carcinomatosis after erlotinib-induced pneumatosis intestinalis

et al. 2018

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BackgroundPneumatosis intestinalis (PI) is a rare complication of chemotherapy, characterized by multiple gas accumulations within the bowel wall.Case presentationA 71-year-old woman with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma was admitted to our hospital because of reduced consciousness. She was diagnosed as having leptomeningeal carcinomatosis (LM) using lumbar puncture. Because she could not swallow a tablet, erlotinib was administered via a feeding tube. Her state of consciousness gradually improved, but she experienced diarrhea several times a day. After 3 weeks of erlotinib therapy, PI occurred. Erlotinib was discontinued and PI was resolved after treatment with conservative therapies. Erlotinib was re-administrated and PI occurred again. After improvement of erlotinib-induced PI, gefitinib was administered by a feeding tube and the patient did not experience PI or diarrhea. The patient survived 8 months from the diagnosis of LM.ConclusionPI is one of the side effects of erlotinib, and consecutive therapies are useful for the treatment of PI. In this patient, gefitinib was successfully administered after erlotinib-induced PI.

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“…Those changes lead to intestinal hypomotility. Bacterial overgrowth and bowel distension are observed in this condition, which can lead to elevated intraluminal pressure and force gas into the intestinal walls (6,19). Bacterial infection has also been proposed to either damage the intestinal wall with subsequent intramural penetration of gas or produce gas, which then penetrates into the gut wall (15).…”

Section: Discussionmentioning

confidence: 99%

Four Cases of Pneumatosis Cystoides Intestinalis Complicated by Connective Tissue Diseases

et al. 2017

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Pneumatosis cystoides intestinalis (PCI) is a rare disease that involves the presence of gas in the intestinal wall. Connective tissue disease (CTD) is a major cause of secondary PCI. In addition to the nature of CTDs, the use of prednisolone and some immunosuppressants, and the presence of complicating diseases such as diabetes mellitus, constipation and pulmonary diseases are involved in the development of PCI. This report describes four cases of PCI with different CTDs (granulomatosis with polyangiitis, rheumatoid arthritis, dermatomyositis, and overlap syndrome) and discusses the background of each patient and common risk factors for the occurrence of PCI.

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Simultaneous Pneumatosis Cystoides Intestinalis and Pneumomediastinum in a Patient with Systemic Sclerosis

Cited by 16 publications

References 9 publications

Spontaneous pneumomediastinum in limited cutaneous systemic sclerosis and myositis overlap

Spontaneous pneumomediastinum in limited cutaneous systemic sclerosis and myositis overlap

Gefitinib successfully administered in a lung cancer patient with leptomeningeal carcinomatosis after erlotinib-induced pneumatosis intestinalis

Four Cases of Pneumatosis Cystoides Intestinalis Complicated by Connective Tissue Diseases

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