Simultaneous PET-MR-EEG: Technology, Challenges and Application in Clinical Neuroscience

Neuner, Irene; Rajkumar, Ravichandran; Brambilla, Cláudia Régio; Ramkiran, Shukti; Ruch, Andrej; Orth, Linda; Farrher, Ezequiel; Mauler, Jörg; Wyss, Christine; Kops, Elena Rota; Scheins, J.; Tellmann, Lutz; Lang, Markus; Ermert, Johannes; Dammers, Jürgen; Lerche, Christoph; Kawohl, Wolfram; Langen, Karl‐Josef; Herzog, Hans; Shah, N. Jon

doi:10.1109/trpms.2018.2886525

Cited by 10 publications

(10 citation statements)

References 67 publications

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“…For this aim, a trimodal approach has been proposed which is integrating an MR-compatible EEG system in a hybrid MR–PET scanner ( Shah et al, 2013 ). This can provide a broader view of the brain activity although the PET attenuation by the EEG-hat can derive technical issues ( Rajkumar et al, 2017 ; Neuner et al, 2019 ; Figures 12 , 13 ).…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Simultaneous electroencephalography-functional magnetic resonance imaging for assessment of human brain function

Ebrahimzadeh

Saharkhiz

Rajabion

et al. 2022

Front. Syst. Neurosci.

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Electroencephalography (EEG) and functional Magnetic Resonance Imaging (MRI) have long been used as tools to examine brain activity. Since both methods are very sensitive to changes of synaptic activity, simultaneous recording of EEG and fMRI can provide both high temporal and spatial resolution. Therefore, the two modalities are now integrated into a hybrid tool, EEG-fMRI, which encapsulates the useful properties of the two. Among other benefits, EEG-fMRI can contribute to a better understanding of brain connectivity and networks. This review lays its focus on the methodologies applied in performing EEG-fMRI studies, namely techniques used for the recording of EEG inside the scanner, artifact removal, and statistical analysis of the fMRI signal. We will investigate simultaneous resting-state and task-based EEG-fMRI studies and discuss their clinical and technological perspectives. Moreover, it is established that the brain regions affected by a task-based neural activity might not be limited to the regions in which they have been initiated. Advanced methods can help reveal the regions responsible for or affected by a developed neural network. Therefore, we have also looked into studies related to characterization of structure and dynamics of brain networks. The reviewed literature suggests that EEG-fMRI can provide valuable complementary information about brain neural networks and functions.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Simultaneous electroencephalography-functional magnetic resonance imaging for assessment of human brain function

Ebrahimzadeh

Saharkhiz

Rajabion

et al. 2022

Front. Syst. Neurosci.

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“…Structural MR data were acquired immediately after the bolus injection, before the tracer reached the equilibrium state. Once the tracer was expected to have reached the steady‐state, a “resting state – task – resting state” paradigm was applied as described in Neuner et al (2018). In the case of [ 11 C]FMZ, the considered list‐mode PET data were framed at 20 × 5 min, and 20 × 2 min framing was used to reconstruct the first 40 min of the [ 11 C]ABP data.…”

Section: Methodsmentioning

confidence: 99%

“…To ensure that a constant equilibrium at the time of interest was reached, TACs were plotted and analyzed prior to the pipeline T A B L E 1 Additional information regarding the groups of volunteers as well as the respective acquisition time (A T ), administered dose (A D ), and bolus fraction K bol in the two considered studies processing. In both datasets, the start of the equilibrium was expected to occur approximately 30 min after injection (Neuner et al, 2018;Régio Brambilla et al, 2020). The TACs in the whole gray matter (GM) and the respective reference regions were normalized to the mean activity in GM during the expected equilibrium phase.…”

Section: Tac Evaluationmentioning

confidence: 99%

mGluR₅ and GABA_A receptor‐specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application

Kaulen

Rajkumar

Brambilla

et al. 2022

Human Brain Mapping

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The glutamate and γ-aminobutyric acid neuroreceptor subtypes mGluR 5 and GABA A are hypothesized to be involved in the development of a variety of psychiatric diseases.However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BP ND ), and total distribution volume (V T ) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and MR data. The pipeline was applied to [ 11 C]ABP688-PET/MR (13 healthy male non-smokers, 26.6 ± 7.0 years) and [ 11 C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as V T and BP ND atlases of mGluR 5 and GABA A , were generated from these data. The maps were validated by assessing the percent error δ from warped space to native space in a selection of brain regions. We verified that the average δ ABP = 3.0 ± 1.0% and δ FMZ = 3.8 ± 1.4% were lower than the expected variabilities σ of the tracers (σ ABP = 4.0%-16.0%, σ FMZ = 3.9%-9.5%). An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [ 15 O]H 2 O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposed pipeline is a viable tool for the construction of standardized PET data distributions.

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“…The development of the simultaneous trimodal neuroimaging approach with positron-emission tomography (PET), magnetic resonance imaging (MR), and EEG (PET/MR-EEG) has accelerated research in this field in recent years. The main advantage of this approach is that structural and functional (via fMRI) and metabolic (via PET) data can be acquired simultaneously under the same physiological and psychological conditions [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [11C]ABP688 PET/MR-EEG

et al. 2022

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Currently, the metabotropic glutamate receptor 5 (mGluR5) is the subject of several lines of research in the context of neurology and is of high interest as a target for positron-emission tomography (PET). Here, we assessed the feasibility of using [11C]ABP688, a specific antagonist radiotracer for an allosteric site on the mGluR5, to evaluate changes in glutamatergic neurotransmission through a mismatch-negativity (MMN) task as a part of a simultaneous and synchronized multimodal PET/MR-EEG study. We analyzed the effect of MMN by comparing the changes in nondisplaceable binding potential (BPND) prior to (baseline) and during the task in 17 healthy subjects by applying a bolus/infusion protocol. Anatomical and functional regions were analyzed. A small change in BPND was observed in anatomical regions (posterior cingulate cortex and thalamus) and in a functional network (precuneus) after the start of the task. The effect size was quantified using Kendall’s W value and was 0.3. The motor cortex was used as a control region for the task and did not show any significant BPND changes. There was a significant ΔBPND between acquisition conditions. On average, the reductions in binding across the regions were - 8.6 ± 3.2% in anatomical and - 6.4 ± 0.5% in the functional network (p ≤ 0.001). Correlations between ΔBPND and EEG latency for both anatomical (p = 0.008) and functional (p = 0.022) regions were found. Exploratory analyses suggest that the MMN task played a role in the glutamatergic neurotransmission, and mGluR5 may be indirectly modulated by these changes.

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Simultaneous PET-MR-EEG: Technology, Challenges and Application in Clinical Neuroscience

Cited by 10 publications

References 67 publications

Simultaneous electroencephalography-functional magnetic resonance imaging for assessment of human brain function

Simultaneous electroencephalography-functional magnetic resonance imaging for assessment of human brain function

mGluR₅ and GABA_A receptor‐specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application

mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [11C]ABP688 PET/MR-EEG

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Simultaneous PET-MR-EEG: Technology, Challenges and Application in Clinical Neuroscience

Cited by 10 publications

References 67 publications

Simultaneous electroencephalography-functional magnetic resonance imaging for assessment of human brain function

Simultaneous electroencephalography-functional magnetic resonance imaging for assessment of human brain function

mGluR5 and GABAA receptor‐specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application

mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [11C]ABP688 PET/MR-EEG

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mGluR₅ and GABA_A receptor‐specific parametric PET atlas construction—PET/MR data processing pipeline, validation, and application