Simultaneous pancreas-kidney transplantation reduces excess mortality in type 1 diabetic patients with end-stage renal disease

Abstract

These data demonstrate that SPK improves the ability for type 1 diabetic patients to live more of their expected life span. This suggests that glycemic control, even as a late intervention in a diabetic patient's lifetime, may beneficially affect survival.

Renal Replacement Therapy in Patients with Diabetes and End-Stage Renal Disease

“…A particularly promising strategy for patients with type 1 diabetes and ESRD is simultaneous pancreas and kidney transplantation (SPKT), as suggested by recent observational studies that have indeed reported a significant survival advantage for SPKT recipients with type 1 diabetes over cadaver kidney transplant recipients, whereas the results of the comparison with living donor kidney transplant recipients have not been unequivocal (25,26). Furthermore, it also should be remembered that SPKT improves the quality of life and a number of secondary complications of diabetes, including gastric and bladder function, metabolic impairment, and autonomic polyneuropathy (27,28).…”

Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile

“…En concordancia con resultados obtenidos en grandes centros [12][13][14] , en esta experiencia la sobrevida de pacientes fue de 70%, la sobrevida de páncreas 72% y la sobrevida de riñón fue de 73% en 10 años cifras superiores a la sobrevida de diabéticos en diálisis en lista de espera de trasplante, que es 46% a cuatro años 15 . Al fi nal del período de observación 9 pacientes estaban euglicémicos en ayunas, presentaban niveles normales de Péptido C e independencia de insulina o hipoglicemiantes orales, independencia de diálisis en 8 pacientes.…”

Kidney Graft and Patient Survival With and Without a Simultaneous Pancreas Utilizing Contralateral Kidneys From the Same Donor

“…Previous studies comparing survival rates between SPK and KA recipients showed conflicting results (5)(6)(7)(8)(9)(10)(11). In some studies, more favorable donors were used for SPK and healthier recipients received SPKs (5,7,8,11).…”