Simultaneous Onset of Vogt-Koyanagi-Harada Syndrome in Monozygotic Twins

Rutzen, Allan R.; Ortega-Larrocea, Gabriela; Schwab, Ivan R.; Rao, Narsing A.

doi:10.1016/s0002-9394(14)73884-x

Cited by 36 publications

(12 citation statements)

References 4 publications

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“…The immunogenetic predisposition in patients who have the syndrome appears to be related to the HLA haplotypes. The same HLA-DR4 allele was identified in monozygotic twins from Vietnam who had the syndrome 18 . The disease has the strongest association with the HLA-DR4 allele in different groups of patients, but other alleles have also shown themselves to be determinants of the syndrome's emergence, including HLA-DR53, DQ54, DQ7 and DR1 7,19 .…”

Section: Etiology and Pathogenesismentioning

confidence: 69%

Síndrome de Vogt-Koyanagi-Harada e o seu acometimento multissistêmico

Mota¹,

Santos²

2010

Rev. Assoc. Med. Bras.

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Vogt-Koyanagi-Harada's syndrome is a rare disease that affects tissues containing melanocytes, such as the eyes, central nervous system, inner ear and skin. Some ethnic groups have a higher probability of developing the disease, including Asians, Indians and Latin Americans and females are affected more often. Methods: Literature was reviewed in books, articles published on the internet and papers available in the online databases MEDLINE, LILACS and SciELO. Texts were selected that focused on otorhinolaryngological symptoms. Literature review: The disease probably has autoimmune etiology, with aggression occurring on the surface of melanocytes by promoting inflammatory reaction in which T lymphocytes predominate. The allele most often found in association with this disease is HLA DRB1*0405. Clinical manifestations are divided into four stages: prodromal, uveitic, chronic and recurrent. Otorhinolaryngological symptoms occur during the uveitic stage and are characterized by bilateral sensorineural hearing loss, tinnitus and vestibular symptoms. Diagnosis is made according to the diagnostic criteria for the disease. Treatment is primarily with corticosteroids. Conclusions: It is important that professionals in other specialties are able to recognize Vogt-Koyanagi-Harada's syndrome, because late diagnosis can lead to ocular and cutaneous sequelae.

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Section: Etiology and Pathogenesismentioning

confidence: 69%

Síndrome de Vogt-Koyanagi-Harada e o seu acometimento multissistêmico

Mota¹,

Santos²

2010

Rev. Assoc. Med. Bras.

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“…7,22,23 Previous studies showed that this disease occasionally displays a familial aggregation pattern. 24,25 Recently, several immune response-related genes have been shown to be associated with BD. 15 These data suggest that genetic factors may play an important role in the pathogenesis of this disease.…”

Section: Discussionmentioning

confidence: 99%

JAK2andSTAT3Polymorphisms in a Han Chinese Population with Behçet's Disease

Hou

Jiang

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…The cause of VKH syndrome is unknown. Some investigators have proposed that the syndrome may be an autoimmune disease associated with genetic factors, because of the close association with human leukocyte antigen (HLA) DR4 in Japanese patients [6] and an occurrence of the syndrome in blood relatives [4,7]. Others have demonstrated EpsteinBarr virus in the cerebrospinal fluid or the vitreous from patients with VKH syndrome [1,8].…”

Section: Introductionmentioning

confidence: 99%