Simultaneous Occurrence of Medullary Carcinoma and Papillary Microcarcinoma of Thyroid in a Patient with Men 2A Syndrome. Report of a Case

Giacomelli, Luciano; Guerriero, Gabriella; Falvo, L; Altomare, Vittorio; Chiesa, Carlo; Ferri, Simone; Stio, F

doi:10.1177/030089160709300121

Cited by 15 publications

(12 citation statements)

References 15 publications

(15 reference statements)

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“…Darwish et al suggests that lymphocytic infiltration, present in some forms of thyroiditis, may predispose a patient to the condition. Furthermore, in the case of medullary and papillary collision, the risk is thought to be increased by multiple endocrine neoplastic syndromes . Ultimately, there is simply not enough data, evidence, or understanding to support or exclude any one hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Collision tumors of the thyroid: A case report and review of the literature

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Collision tumors of the thyroid: A case report and review of the literature

et al. 2015

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“…These microcarcinomas PTCs are likely to carry only modest clinical significance as microscopic PTCs often remain clinically silent and as affected subjects carrying germline RET mutations undergo thyroidectomy at a young age. 55,89,90 Occasionally, the occurrence of both tumors together, as a collision tumor, is identified on MEN2A patients (Fig. 9).…”

Section: Werner Syndromementioning

confidence: 99%

Familial Thyroid Carcinoma

Dotto¹,

Nosé²

2008

Advances in Anatomic Pathology

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Thyroid carcinomas derived from follicular cells are the most common endocrine malignancies, and papillary thyroid carcinoma (PTC) is the most common type. Although, the majority of papillary and follicular thyroid carcinomas (FTCs) are sporadic, familial forms have been described in recent years. Familial syndromes are classified into familial medullary thyroid carcinoma and familial nonmedullary thyroid carcinoma. Multifocal papillary carcinoma is the most frequent presentation of familial nonmedullary thyroid carcinoma, and based on clinico-pathologic findings it is divided into 2 groups. The first includes familial syndromes characterized by a predominance of nonthyroidal tumors, such as familial adenomatous polyposis, PTEN-hamartoma tumor syndrome, Carney complex type 1, and Werner syndrome. The second group includes familial syndromes characterized by a predominance of NMTC, such as pure familial (f) PTC with or without oxyphilia, fPTC with papillary renal cell carcinoma, and fPTC with multinodular goiter. Medullary thyroid carcinoma is derived from calcitonin-producing C cells. The familial form accounts for 20% to 25% of cases, and is usually a component of multiple endocrine neoplasia (MEN) IIA or IIB, or presents as pure familial medullary thyroid carcinoma syndrome. C-cell hyperplasia is the precursor lesion of these heritable syndromes. Some characteristic morphologic findings should alert the pathologist of a possible familial cancer syndrome, which may lead to further molecular genetic evaluation.

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“…These microcarcinomas are likely to carry only modest clinical significance, as microscopic PTCs often remain clinically silent and affected subjects carrying germline RET mutations undergo thyroidectomy at a young age. 59,60 Familial Tumor Syndromes Characterized by a Predominance of Non-medullary Thyroid Carcinoma FNMTC syndrome is diagnosed when three or more family members have non-medullary thyroid cancer in the absence of other known associated syndromes. Statistical estimates suggest that a grouping of two family members with NMTC could represent the concurrence of sporadic tumors, but thyroid tumors in three or more members in kindred, or the diagnosis of PTC in men and children, is more suggestive of a familial predisposition.…”

Section: -58mentioning

confidence: 99%