Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times

Bergmann, Jean‐François; Chassany, Olivier; Pj, Guillausseau; Bayle, Marciano Sánchez; Chagnon, S; Caulin, C; Sallenave, J. R.

doi:10.1007/bf01740656

Cited by 6 publications

(2 citation statements)

References 23 publications

(24 reference statements)

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“…Compared with ROM. There is evidence that GE is accelerated similarly by rectal or oral cisapride when measured by scintigraphy and by ROM (29,30). Several lines of evidence (31,32) suggest that scintigraphy, when compared with ROM, is more accurate in assessing the emptying of the digestible solid food from the stomach.…”

Section: Recommendationmentioning

confidence: 99%

ACG Clinical Guideline: Gastroparesis

et al. 2022

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Gastroparesis is characterized by symptoms suggesting retention of food in the stomach with objective evidence of delayed gastric emptying in the absence of mechanical obstruction in the gastric outflow. This condition is increasingly encountered in clinical practice. These guidelines summarize perspectives on the risk factors, diagnosis, and management of gastroparesis in adults (including dietary, pharmacological, device, and interventions directed at the pylorus), and they represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation process. When the evidence was not appropriate for Grading of Recommendations, Assessment, Development, and Evaluation, we used expert consensus to develop key concept statements. These guidelines should be considered as preferred but are not the only approaches to these conditions.

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Section: Recommendationmentioning

confidence: 99%

ACG Clinical Guideline: Gastroparesis

et al. 2022

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“…Thus most investigators agree that cisapride accelerates MCTT, not only in control subjects23 24 but also in patients with diabetes mellitus,60 spinal cord injury,61 and chronic intestinal pseudo obstruction,62 all of whom have prolonged orocaecal transit. Cisapride also reduces colonic transit in control subjects25 and in patients with idiopathic constipation,63 Parkinson's disease,64diabetes mellitus,65 postoperative ileus,66and spinal cord injury 67.…”

Section: Discussionmentioning

confidence: 96%

Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial

Veysey

Malcolm²,

Mallet³

et al. 2001

Gut

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Background-Octreotide inhibits gall bladder emptying and prolongs intestinal transit. This leads to increases in the proportion of deoxycholic acid in, and cholesterol saturation of, gall bladder bile, factors that contribute to the pathogenesis of octreotide induced gall stones. Aims-To see if an intestinal prokinetic, cisapride, could overcome these adverse eVects of octreotide and if so, be considered as a candidate prophylactic drug for preventing iatrogenic gall bladder stones. Methods-A randomised, double blind, placebo controlled, crossover design was used to examine the eVects of cisapride (10 mg four times daily) on gall bladder emptying, mouth to caecum and large bowel transit times, and the proportions of deoxycholic acid and other bile acids, in fasting serum from: (i) control subjects (n=6), (ii) acromegalic patients not treated with octreotide (n=6), (iii) acromegalics on long term octreotide (n=8), and (iv) patients with constipation (n=8). Results-Cisapride had no prokinetic effect on the gall bladder. In fact, it significantly increased both fasting and postprandial gall bladder volumes. However, it shortened mouth to caecum (from 176 (13) to 113 (11) minutes; p<0.001) and large bowel (from 50 (3.0) to 31 (3.4) h; p<0.001) transit times. It also reduced the proportion of deoxycholic acid in serum from 26 (2.3) to 15 (1.8)% (p<0.001), with a reciprocal increase in the proportion of cholic acid from 40 (3.5) to 51 (3.8)% (p<0.01). There were significant linear relationships between large bowel transit time and the proportions of deoxycholic acid (r=0.81; p<0.001) and cholic acid (r=−0.53; p<0.001) in fasting serum. Interpretation/summary-Cisapride failed to overcome the adverse eVects of octreotide on gall bladder emptying but it countered octreotide induced prolongation of small and large bowel transit. Therefore, if changes in intestinal transit contribute to the development of octreotide induced gall bladder stones, enterokinetics such as cisapride may prevent their formation. (Gut 2001;49:828-834)

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Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: An ultrasonographic study

et al. 1996

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An ultrasonographic study of ten healthy volunteers was carried out to evaluate the effect of cisapride on gastric antral emptying. More than 1 week after the measurement of the baseline emptying rate, cisapride was given at a single oral dose of 5 mg 30 minutes before intake of a balanced liquid test meal (5 ml/kg body weight). To determine the time to half emptying (T1/2), an exponential curve was extrapolated for the elimination phase of the gastroantral sagittal cross-sectional area plotted against time. The T1/2 was reduced by 18.5% after cisapride, from 62.6 +/- 4.3 to 51.0 +/- 4.4 min (P = 0.0284). We conclude that a single oral dose of 5 mg of cisapride significantly accelerates the gastric antral emptying rate in healthy humans.

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Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times

Cited by 6 publications

References 23 publications

ACG Clinical Guideline: Gastroparesis

ACG Clinical Guideline: Gastroparesis

Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial

Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: An ultrasonographic study

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