Simultaneous Noncentered Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking and Penetrating Keratoplasty for Treatment of Severe Marginal<i> Fusarium </i>spp. Keratitis: A Description of a New Surgical Technique

Balparda, Kepa; Mejía-Turizo, Juan Carlos; Herrera-Chalarca, Tatiana

doi:10.1155/2017/6987896

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…Positive effects were also reported by clinicians from Columbia, who successfully treated a case of severe marginal Fusarium spp. with imminent perforation using novel surgical technique of simultaneous therapeutical keratoplasty and PACK-CXL [ 131 ].…”

Section: Crosslinkingmentioning

confidence: 99%

Fusarium Keratitis—Review of Current Treatment Possibilities

Szaliński

Zgryźniak

Rubisz³

et al. 2021

JCM

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In many parts of the world, fungi are the predominant cause of infectious keratitis; among which, Fusarium is the most commonly isolated pathogen. The clinical management of this ophthalmic emergency is challenging. Due to the retardation of the first symptoms from an injury and the inability to differentiate fungal from bacterial infections based on clinical symptoms and difficult microbial diagnostics, proper treatment, in many cases, is postponed. Moreover, therapeutical options of Fusarium keratitis remain limited. This paper summarizes the available treatment modalities of Fusarium keratitis, including antifungals and their routes of administration, antiseptics, and surgical interventions.

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Section: Crosslinkingmentioning

confidence: 99%

Fusarium Keratitis—Review of Current Treatment Possibilities

Szaliński

Zgryźniak

Rubisz³

et al. 2021

JCM

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“…This treatment continues to be the gold standard for this pathology. The CXL-PACK technique was first described by Spörl in 1997, but the antimicrobial properties of riboflavin in combination with UV light have been known since 1965 [ 7 ]. In this patient, the Dresden protocol for CXL-PACK was performed [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cross-linking treatment has recently emerged as a therapeutic option previous to performing keratoplasty. Numerous studies demonstrate the efficacy of ultraviolet light for the inactivation of microorganisms [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Cross-Linking Pack Plus Plasma in the Mycotic Corneal Ulcer Case Report

Vieyra¹,

Martínez²,

Escobar³

2022

Case Rep Ophthalmol

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Fungal keratitis is a complication of refractive surgery that, if not treated in time, can lead to blindness. Given the lack of effective topical treatments for fungal ulcers, surgical treatment is necessary. The least invasive procedure is a cross-linking pack, although it has limitations when the fungus has penetrated the deep layers of the cornea. In this case report, a patient that presented a typical case of fungal corneal ulcer with hand motion perception, on the fourth day after surgery, is described. Given the nonresponse to topical antifungal treatment, plasma treatment was performed prior to cross-linking. Plasma acts by nonmechanical debridement of the ulcer, reducing the fungal colonies and allowing better penetration of riboflavin. After 6 months, the cornea remained transparent, without haze, and the patient achieved 20/25 vision.

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“…Conversely to ours in that case, the abscess was limited to the 3–5 o’clock area and was not associated with corneal melting and graft failure. In a recent case report, Balparda et al [12] proposed the application of PACK-CXL combined with PKP for the treatment of severe marginal Fusarium spp. keratitis on a virgin cornea.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Photoactivated Chromophore for Infectious Keratitis–Corneal Cross-Linking (PACK-CXL) During Penetrating Keratoplasty for the Management of Fungal Keratitis in an Immunocompromised Patient

et al. 2019

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Introduction To present a novel intraoperative application of photoactivated chromophore for infectious keratitis–corneal cross-linking (PACK-CXL) in the management of post-penetrating keratoplasty (PKP) multiresistant fungal keratitis in a patient with irradiation-related local immunosuppression. Case report A 62-year-old female underwent uneventful PKP for the management of post-irradiation actinic keratopathy. Three months postoperatively, she presented with a diffuse corneal melting abscess that was infiltrating the donor-recipient junction. Despite intensive antibiotic and antifungal therapy, corneal melting progressed to graft perforation. A repeat PKP combined with intraoperative PACK-CXL was performed. PACK-CXL was applied initially on the infected graft, involving the corneoscleral rim and then following placement of the donor button. No intra- or postoperative graft-related complications were encountered. No signs of infection were noted, and the graft remained clear during the 9-month follow-up period. Conclusion Intraoperative PACK-CXL combined with PKP appears to be a safe and effective technique for the management of post-PKP resistant fungal keratitis.

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Simultaneous Noncentered Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking and Penetrating Keratoplasty for Treatment of Severe Marginal Fusarium spp. Keratitis: A Description of a New Surgical Technique

Cited by 6 publications

References 31 publications

Fusarium Keratitis—Review of Current Treatment Possibilities

Fusarium Keratitis—Review of Current Treatment Possibilities

Cross-Linking Pack Plus Plasma in the Mycotic Corneal Ulcer Case Report

Intraoperative Photoactivated Chromophore for Infectious Keratitis–Corneal Cross-Linking (PACK-CXL) During Penetrating Keratoplasty for the Management of Fungal Keratitis in an Immunocompromised Patient

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