In order to facilitate communication and communication, this paper studies the optimization of the current computer-aided translation system, and proposed a design method of English communication language computer-aided translation system based on grey clustering evaluation. By optimizing the hardware configuration and algorithm function keys of the system, the English translation mechanism of multilanguage interaction, the design idea of editing and modifying after English translation and knowledge database management are realized, and the system function framework was constructed, including the system transceiver unit, automatic translation unit, manual correction unit, task management unit and memory management unit, the performance of task management unit and memory management unit is analyzed. On this basis, the specific work flow of the design system mainly includes the English translation service flow integrating multilanguage interaction and the project-based multilanguage interaction English translation service flow design, which realizes the English translation online assistance under the multilanguage interaction environment. The experimental results show that the design system has the advantages of high online translation speed, pronunciation success rate and multilanguage translation success rate.