Simultaneous monitoring of sweat lactate content and sweat secretion rate by wearable remote biosensors

Komkova, Maria A.; Eliseev, A. A.; Poyarkov, A.A.; Daboss, Elena V.; Евдокимов, П. В.; Karyakin, Arkady A.

doi:10.1016/j.bios.2022.113970

Cited by 50 publications

(30 citation statements)

References 41 publications

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“…For example, glucose concentrations of tears correlate well with blood glucose levels [ 253 , 254 ]. However, analysis of tear samples is challenging, and it shows several errors such as easily volatile in natures, less secretion compare to other biofluids (secretion rate of sweat is 2 µL min −1 , saliva is 0.5 mL min −1 , and tear is 0.9 µL min −1 in healthy person), non-uniform tear production among individuals, difficult in collection, and handling methods [ 255 – 260 ]. To overcome these issues, the development of wearable tear sensing platforms has garnered attention in the past few decades.…”

Section: Classification Of Graphene-based Wearable Biosensorsmentioning

confidence: 99%

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

et al. 2022

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Given the huge economic burden caused by chronic and acute diseases on human beings, it is an urgent requirement of a cost-effective diagnosis and monitoring process to treat and cure the disease in their preliminary stage to avoid severe complications. Wearable biosensors have been developed by using numerous materials for non-invasive, wireless, and consistent human health monitoring. Graphene, a 2D nanomaterial, has received considerable attention for the development of wearable biosensors due to its outstanding physical, chemical, and structural properties. Moreover, the extremely flexible, foldable, and biocompatible nature of graphene provide a wide scope for developing wearable biosensor devices. Therefore, graphene and its derivatives could be trending materials to fabricate wearable biosensor devices for remote human health management in the near future. Various biofluids and exhaled breath contain many relevant biomarkers which can be exploited by wearable biosensors non-invasively to identify diseases. In this article, we have discussed various methodologies and strategies for synthesizing and pattering graphene. Furthermore, general sensing mechanism of biosensors, and graphene-based biosensing devices for tear, sweat, interstitial fluid (ISF), saliva, and exhaled breath have also been explored and discussed thoroughly. Finally, current challenges and future prospective of graphene-based wearable biosensors have been evaluated with conclusion. Graphical abstract Graphene is a promising 2D material for the development of wearable sensors. Various biofluids (sweat, tears, saliva and ISF) and exhaled breath contains many relevant biomarkers which facilitate in identify diseases. Biosensor is made up of biological recognition element such as enzyme, antibody, nucleic acid, hormone, organelle, or complete cell and physical (transducer, amplifier), provide fast response without causing organ harm.

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Section: Classification Of Graphene-based Wearable Biosensorsmentioning

confidence: 99%

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

et al. 2022

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“…Biosensors with programmed diagnostic functions can measure, for instance, blood temperature, pressure, pH, glucose concentration, hormonal, and alcohol levels, and are becoming more and more popular. They can also can be used to detect human movement, or small toxic molecules [ 75 , 76 , 77 , 78 ]. Biosensors usually attach to specified positions in the human body, where important biomarkers (e.g., pressure, alcohol level) can be best collected.…”

Section: Numerical Resultsmentioning

confidence: 99%

Modeling Tunable Fracture in Hydrogel Shell Structures for Biomedical Applications

Zhang

Qiu

Elkhodary

et al. 2022

Gels

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Hydrogels are nowadays widely used in various biomedical applications, and show great potential for the making of devices such as biosensors, drug- delivery vectors, carriers, or matrices for cell cultures in tissue engineering, etc. In these applications, due to the irregular complex surface of the human body or its organs/structures, the devices are often designed with a small thickness, and are required to be flexible when attached to biological surfaces. The devices will deform as driven by human motion and under external loading. In terms of mechanical modeling, most of these devices can be abstracted as shells. In this paper, we propose a mixed graph-finite element method (FEM) phase field approach to model the fracture of curved shells composed of hydrogels, for biomedical applications. We present herein examples for the fracture of a wearable biosensor, a membrane-coated drug, and a matrix for a cell culture, each made of a hydrogel. Used in combination with experimental material testing, our method opens a new pathway to the efficient modeling of fracture in biomedical devices with surfaces of arbitrary curvature, helping in the design of devices with tunable fracture properties.

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“…Enzymes (lactate dehydrogenase (LDH) and lactate oxidase (LOx/LOD)) are frequently added to make the sensor selective. Prussian blue (PB), which is a good electron transfer mediator and can lower the redox reaction potential, can also be employed to further limit the introduction of interfering signals and improve sensor selectivity [ 38 , 39 , 40 , 41 , 42 , 43 ]. Additionally, a layer of semi-permeable membrane, made by perfluorosulfonic acid type polymers (Nafion) with specific size or charge molecule repulsion can also be coated on the electrode surface to lessen the passage of interfering species [ 9 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate

Shen

Liu

et al. 2022

Biosensors

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Lactate, a crucial product of the anaerobic metabolism of carbohydrates in the human body, is of enormous significance in the diagnosis and treatment of diseases and scientific exercise management. The level of lactate in the bio-fluid is a crucial health indicator because it is related to diseases, such as hypoxia, metabolic disorders, renal failure, heart failure, and respiratory failure. For critically ill patients and those who need to regularly control lactate levels, it is vital to develop a non-invasive wearable sensor to detect lactate levels in matrices other than blood. Due to its high sensitivity, high selectivity, low detection limit, simplicity of use, and ability to identify target molecules in the presence of interfering chemicals, biosensing is a potential analytical approach for lactate detection that has received increasing attention. Various types of wearable lactate biosensors are reviewed in this paper, along with their preparation, key properties, and commonly used flexible substrate materials including polydimethylsiloxane (PDMS), polyethylene terephthalate (PET), paper, and textiles. Key performance indicators, including sensitivity, linear detection range, and detection limit, are also compared. The challenges for future development are also summarized, along with some recommendations for the future development of lactate biosensors.

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Simultaneous monitoring of sweat lactate content and sweat secretion rate by wearable remote biosensors

Cited by 50 publications

References 41 publications

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

Modeling Tunable Fracture in Hydrogel Shell Structures for Biomedical Applications

Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate

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