Simultaneous measurements of cerebral oxygenation changes during brain activation by near-infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects

Mehagnoul-Schipper, D.J.; Kallen, Bas F.W. van der; Colier, Willy N.J.M.; Sluijs, Marco C. van der; Erning, L.J.T.O. van; Thijssen, H.O.M.; Oeseburg, B.; Hoefnagels, W.H.L.; Jansen, René W. M. M.

doi:10.1002/hbm.10026.abs

Cited by 35 publications

(46 citation statements)

References 29 publications

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“…Our data agree well with Ogawa et al (1993) and Buxton et al (1998), which assume that the BOLD signal arises mainly from magnetic disturbances caused by the paramagnetic deoxy-Hb. Our data are also consistent with simultaneous fMRI and fNIRS experiments showing a high correlation between the BOLD signal and deoxy-Hb (Kida et al, 1996;Mehagnoul-Schipper et al, 2002;Punwani et al, 1997Punwani et al, , 1998Toronov et al, 2003) and with Pouratian et al (2002) who showed a high temporal and spatial correlation between the BOLD signal and optical intrinsic signals measured at 610 nm (particularly sensitive to deoxy-Hb) in humans. Differences to Strangman et al (2002), who found a lower correlation of the BOLD signal with deoxy-compared with oxy-Hb during finger flexion/ extension motor activation, may be explained by their less (three) subjects, different (block) design, their shorter emitter -detector separation (Germon et al, 1999), and non-linear changes of oxyHb in relation to deoxy-Hb in the motor cortex (Wolf et al, 2002).…”

Section: Discussionsupporting

confidence: 91%

“…Several recent studies compared the hemodynamic response to brain activation as measured by functional near-infrared spectroscopy (fNIRS) with another imaging method, such as functional magnetic resonance imaging (fMRI) (Hoge et al, 2005;Kennan et al, 2002;Kleinschmidt et al, 1996;Mehagnoul-Schipper et al, 2002;Obrig et al, 2000b;Seiyama et al, 2004;Siegel et al, 2003;Strangman et al, 2002;Toronov et al, 2001aToronov et al, ,b, 2003Wenzel et al, 2000) or positron emission tomography (PET) . While optical measurements are poorer in spatial resolution and depth penetration than fMRI, they are biochemical specific and, consequently, provide information about changes in oxy-, deoxy-, and total hemoglobin (Hb) with a high temporal resolution (Hoshi, 2003;Villringer and Chance, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Investigating the post-stimulus undershoot of the BOLD signal—a simultaneous fMRI and fNIRS study

et al. 2006

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Measuring the hemodynamic response with functional magnetic resonance imaging (fMRI) together with functional near-infrared spectroscopy (fNIRS) may overcome limitations of single-method approaches. Accordingly, we measured the event-related hemodynamic response with both imaging methods simultaneously in young subjects during visual stimulation. An intertrial interval of 60 s was chosen to include the prolonged post-stimulus undershoot of the blood oxygenation level dependent (BOLD) signal. During visual stimulation, the BOLD signal, oxy-, and total hemoglobin (Hb) increased, whereas deoxy-Hb decreased. The post-stimulus period was characterized by an undershoot of the BOLD signal, oxy-Hb, and an overshoot of deoxy-Hb. Total Hb as measured by fNIRS returned to baseline immediately after the end of stimulation. Results suggest that the post-stimulus events as measured by fNIRS are dominated by a prolonged high-level oxygen consumption in the microvasculature. The contribution of a delayed return of blood volume to the BOLD post-stimulus undershoot in post-capillary veins as suggested by the Balloon and Windkessel models remains ambiguous. Temporal changes in the BOLD signal were highly correlated with deoxy-Hb, with lower correlation values for oxy-and total Hb. Furthermore, data show that fNIRS covers the outer 1 cm of the brain cortex. These results were confirmed by simultaneous fMRI/fNIRS measurements during rest. In conclusion, multimodal imaging approaches may contribute to the understanding of neurovascular coupling. D

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Investigating the post-stimulus undershoot of the BOLD signal—a simultaneous fMRI and fNIRS study

et al. 2006

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“…When we use activation and deactivation in the present article, therefore, we are using the operational definition, unless a more general meaning is explicitly stated. The decrease in [deoxy-Hb] corresponds to an increase in BOLD contrast, as has been shown by several studies (Kleinschmidt et al, 1996;Mehagnoul-Schipper et al, 2002). If no change in [deoxyHb] is seen (and the concomitant increase in [oxy-Hb] is therefore judged the relevant change, indicating cerebral activation [using the general sense of the word]) the interpretation of the results should at least consider that the alleged activation would not show in a BOLD-contrast fMRI study!…”

Section: Physiology Of the Signalmentioning

confidence: 78%

Beyond the Visible—Imaging the Human Brain with Light

Obrig

Villringer

2003

J Cereb Blood Flow Metab

548

215

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Summary:Optical approaches to investigate cerebral function and metabolism have long been applied in invasive studies. From the neuron cultured in vitro to the exposed cortex in the human during neurosurgical procedures, high spatial resolution can be reached and several processes such as membrane potential, cell swelling, metabolism of mitochondrial chromophores, and vascular response can be monitored, depending on the respective preparation. The authors focus on an extension of optical methods to the noninvasive application in the human. Starting with the pioneering work of Jöbsis 25 years ago, nearinfrared spectroscopy (NIRS) has been used to investigate functional activation of the human cerebral cortex. Recently, several groups have started to use imaging systems that allow the generation of images of a larger area of the subject's head and, thereby, the production of maps of cortical oxygenation changes. Such images have a much lower spatial resolution compared with the invasively obtained optical images. The noninvasive NIRS images, however, can be obtained in undemanding set-ups that can be easily combined with other functional methods, in particular EEG. Moreover, NIRS is applicable to bedside use. The authors briefly review some of the abundant literature on intrinsic optical signals and the NIRS imaging studies of the past few years. The weaknesses and strengths of the approach are critically discussed. The authors conclude that NIRS imaging has two major advantages: it can address issues concerning neurovascular coupling in the human adult and can extend functional imaging approaches to the investigation of the diseased brain. Key Words: Near-infrared spectroscopy-Cerebral oxygenation-Vascular imagingNoninvasive.The first investigations into the functional anatomy of the human cerebral cortex were based on lesion studies. The role of specific cortical areas involved in a specific task was inferred by comparing a patient's dysfunction to the lesion seen at autopsy (Fig. 1A). Whereas initially only electrophysiologic techniques allowed noninvasive functional studies of the human brain, the advent of modern imaging techniques such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) have increasingly dominated the field during the past decade. The great advantage is the spatial resolution, which for fMRI is steadily improving and may even allow the differentiation of different cortical layers.There is an increasing need, however, for a better understanding of the signal physiology, in particular of blood oxygenation level-dependent (BOLD) contrast, since the basic principles of the coupling between the neuronal and the vascular response to functional stimulation are still not fully understood (Villringer and Dirnagl, 1995).In the present article we focus on noninvasive imaging approaches in the human using light. Near-infrared spectroscopy (NIRS),* the technique on which such imaging approaches are based, has been covered in previous articles that reviewed its potential...

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“…Studies of functional brain activity acquired simultaneously by fMRI and near-infrared techniques have increased significantly in recent years (Boas et al, 2004a,b;Hoge et al, 2005;Horovitz and Gore, 2004;Kennan et al, 2002;Mehagnoul-Schipper et al, 2002;Okamoto et al, 2004;Seiyama et al, 2003Seiyama et al, , 2004Strangman et al, 2002;Toronov et al, 2001a,b). In order to be able to compare the results of both techniques, it is helpful to apply the same analysis techniques to the data from both modalities.…”

Section: Discussionmentioning

confidence: 99%

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

2007

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Functional near infrared spectro-imaging (fNIRSI) is potentially a very useful technique for obtaining information about the underlying physiology of the blood oxygenation level dependent (BOLD) signal used in functional magnetic resonance imaging (fMRI). In this paper the temporal and spatial statistical characteristics of fNIRSI data are compared to those of simultaneously acquired fMRI data in the human visual cortex during a variable-frequency reversing checkerboard activation paradigm. Changes in the size of activated volume caused by changes in checkerboard reversal frequency allowed a comparison of the behavior of the spatial responses measured by the two imaging methods. fNIRSI and fMRI data were each analyzed using standard correlation and fixed-effect group analyses of variance pathways. The statistical significance of fNIRSI data was found to be much lower than that of the fMRI data, due mainly to the low signal-to-noise of the measurements. Reconstructed images also showed that, while the time-course of changes in the oxy-, deoxy-, and total hemoglobin concentrations all exhibit high correlation with that of the BOLD response, the changes in the volume of tissue measured as "activated" by the BOLD response demonstrate a closer similarity to the corresponding changes in the oxy-and total hemoglobin concentrations than to that of the deoxyhemoglobin.

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Simultaneous measurements of cerebral oxygenation changes during brain activation by near-infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects

Cited by 35 publications

References 29 publications

Investigating the post-stimulus undershoot of the BOLD signal—a simultaneous fMRI and fNIRS study

Investigating the post-stimulus undershoot of the BOLD signal—a simultaneous fMRI and fNIRS study

Beyond the Visible—Imaging the Human Brain with Light

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

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