Simultaneous measurement of total water content and myelin water fraction in brain at 3 T using a T 2 relaxation based method

Meyers, Sandra M.; Kolind, Shannon; MacKay, Alex L.

doi:10.1016/j.mri.2016.12.001

Cited by 38 publications

(30 citation statements)

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“…47 Our relatively high SNR and additional echoes at short T 2 times (compared to the more common ΔTE of 10 ms) should allow signal amplitude fluctuations at early echoes, because of stimulated echo artifacts, to be more easily distinguished from signal reduction due to short T A B L E 4 Mean and SD of the MWF ROI values and corresponding repeatability metrics for multi-echo T 2 relaxation imaging with compressed sensing and partial Fourier acceleration (METRICS-PF) repeatability subjects' scan 1 and scan 2 For METRICS and METRICS-PF, our mean MWF LOA (−2.2|2.9 and −1.4|2.0) and RC (1.5 and 1.1) are comparable to those of the 2D GRASE sequence with parallel imaging acceleration factors (AF) of 1 (LOA = −2.4|2.3, RC = 1.9) and 2 (LOA = −2.5|2.9, RC = 2.1). 22 Our mean MWF COV of 6.2% and 4.5% are comparable or better than that reported for single-slice 2D MSE (19%, 12.6%), 48,49 3D MSE (intra-site 3.99%, inter-site 4.68%), 18 3D GRASE (single subject 13.4%), 50 and 2D MS GRASE (6.1% for AF = 1, 6.7% for AF = 2). 22 Our mean MWF ICC (0.79 and 0.84) are comparable to that of 3D MSE (intra-site 0.76, inter-site 0.69), 18 3D GRASE (0.83), 51 and 2D MS GRASE (0.88 for AF = 1, 0.80 for AF = 2).…”

Section: Quality and Repeatabilitysupporting

confidence: 69%

Multi‐spin echo T₂ relaxation imaging with compressed sensing (METRICS) for rapid myelin water imaging

Dvorak

Wiggermann

Gilbert

et al. 2020

Magnetic Resonance in Med

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Purpose: Myelin water imaging (MWI) provides a valuable biomarker for myelin, but clinical application has been restricted by long acquisition times. Accelerating the standard multi-echo T 2 acquisition with gradient echoes (GRASE) or by 2D multislice data collection results in image blurring, contrast changes, and other issues.Compressed sensing (CS) can vastly accelerate conventional MRI. In this work, we assessed the use of CS for in vivo human MWI, using a 3D multi spin-echo sequence. Methods: We implemented multi-echo T 2 relaxation imaging with compressed sensing (METRICS) and METRICS with partial Fourier acceleration (METRICS-PF).Scan-rescan data were acquired from 12 healthy controls for assessment of repeatability. MWI data were acquired for METRICS in 9 m:58 s and for METRICS-PF in 7 m:25 s, both with 1.5 × 2 × 3 mm 3 voxels, 56 echoes, 7 ms ΔTE, and 240 × 240 × 170 mm 3 FOV. METRICS was compared with a novel multi-echo spinecho gold-standard (MSE-GS) MWI acquisition, acquired for a single additional subject in 2 h:2 m:40 s. Results: METRICS/METRICS-PF myelin water fraction had mean: repeatability coefficient 1.5/1.1, coefficient of variation 6.2/4.5%, and intra-class correlation coefficient 0.79/0.84. Repeatability metrics comparing METRICS with METRICS-PF were similar, and both sequences agreed with reference values from literature. METRICS images and quantitative maps showed excellent qualitative agreement with those of MSE-GS. | 1265 DVORAK et Al.

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Section: Quality and Repeatabilitysupporting

confidence: 69%

Multi‐spin echo T₂ relaxation imaging with compressed sensing (METRICS) for rapid myelin water imaging

Dvorak

Wiggermann

Gilbert

et al. 2020

Magnetic Resonance in Med

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“…These concentrations are in good agreement with previous studies using myelin water imaging. [49][50][51] The values are also in good agreement with a conversion between MWF and MVF presented recently. 52 Note, however, that myelin not only affects the R 2 * of myelin water but all water in the vicinity of myelin.…”

Section: Discussionsupporting

confidence: 90%

“…Assuming a myelin water content of 50%, the MVF of 17.32% in controls, 18.19% in siblings, and 16.02% in patients translate to MWFs of 8.66%, 9.10%, and 8.01%, respectively. These concentrations are in good agreement with previous studies using myelin water imaging . The values are also in good agreement with a conversion between MWF and MVF presented recently .…”

Section: Discussionmentioning

confidence: 99%

The role of iron and myelin in orientation dependent R₂^* of white matter

et al. 2019

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Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In structures with low myelin content, such as deep gray matter, R2* shows a linear increase with increasing iron content. In white matter, R2* is not only affected by iron and myelin but also by the orientation of the myelinated axons with respect to the external magnetic field. Here, we propose a numerical model which incorporates iron and myelin, as well as fibre orientation, to simulate R2* decay in white matter. Applying our model to fibre orientation‐dependent in vivo R2* data, we are able to determine a unique solution of myelin and iron content in global white matter. We determine an averaged myelin volume fraction of 16.02 ± 2.07% in non‐lesional white matter of patients with MS, 17.32 ± 2.20% in matched healthy controls, and 18.19 ± 2.98% in healthy siblings of patients with MS. Averaged iron content was 35.6 ± 8.9 mg/kg tissue in patients, 43.1 ± 8.3 mg/kg in controls, and 47.8 ± 8.2 mg/kg in siblings. All differences in iron content between groups were significant, while the difference in myelin content between MS patients and the siblings of MS patients was significant. In conclusion, we demonstrate that a model that combines myelin‐induced orientation‐dependent and iron‐induced orientation‐independent components is able to fit in vivo R2* data.

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“…To the best of our knowledge, PD-weighted MRI has never been used to assess hydration states within the vocal folds of rats, although it has been used to assess water content in other tissue. [14][15][16][17][18] Systemic dehydration was defined as 10% loss in body weight resulting from withholding water. A loss of 1% body weight due to diuretic ingestion in young, healthy adults can negatively affect voice.…”

Section: Introductionmentioning

confidence: 99%

Proton density–weighted laryngeal magnetic resonance imaging in systemically dehydrated rats

Oleson

Liu

et al. 2017

The Laryngoscope

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Simultaneous measurement of total water content and myelin water fraction in brain at 3 T using a T 2 relaxation based method

Cited by 38 publications

References 50 publications

Multi‐spin echo T₂ relaxation imaging with compressed sensing (METRICS) for rapid myelin water imaging

Multi‐spin echo T₂ relaxation imaging with compressed sensing (METRICS) for rapid myelin water imaging

The role of iron and myelin in orientation dependent R₂^* of white matter

Proton density–weighted laryngeal magnetic resonance imaging in systemically dehydrated rats

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Simultaneous measurement of total water content and myelin water fraction in brain at 3 T using a T 2 relaxation based method

Cited by 38 publications

References 50 publications

Multi‐spin echo T2 relaxation imaging with compressed sensing (METRICS) for rapid myelin water imaging

Multi‐spin echo T2 relaxation imaging with compressed sensing (METRICS) for rapid myelin water imaging

The role of iron and myelin in orientation dependent R2* of white matter

Proton density–weighted laryngeal magnetic resonance imaging in systemically dehydrated rats

Contact Info

Product

Resources

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Multi‐spin echo T₂ relaxation imaging with compressed sensing (METRICS) for rapid myelin water imaging

Multi‐spin echo T₂ relaxation imaging with compressed sensing (METRICS) for rapid myelin water imaging

The role of iron and myelin in orientation dependent R₂^* of white matter