Simultaneous Measurement of Cerebral Tissue Oxygenation over the Adult Frontal and Motor Cortex During Rest and Functional Activation

Leung, Terence S.; Elwell, Clare E.; Henty, J; Delpy, David T.

doi:10.1007/978-1-4615-0205-0_64

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…Both the levels and direction of change of the haemoglobin signals are comparable with previous experimental data [24] , although the magnitudes predicted are somewhat higher than reported in [5] .…”

Section: Resultssupporting

confidence: 88%

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A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges

Banaji

Mallet²,

Elwell³

et al. 2008

PLoS Comput Biol

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We construct a model of brain circulation and energy metabolism. The model is designed to explain experimental data and predict the response of the circulation and metabolism to a variety of stimuli, in particular, changes in arterial blood pressure, CO2 levels, O2 levels, and functional activation. Significant model outputs are predictions about blood flow, metabolic rate, and quantities measurable noninvasively using near-infrared spectroscopy (NIRS), including cerebral blood volume and oxygenation and the redox state of the CuA centre in cytochrome c oxidase. These quantities are now frequently measured in clinical settings; however the relationship between the measurements and the underlying physiological events is in general complex. We anticipate that the model will play an important role in helping to understand the NIRS signals, in particular, the cytochrome signal, which has been hard to interpret. A range of model simulations are presented, and model outputs are compared to published data obtained from both in vivo and in vitro settings. The comparisons are encouraging, showing that the model is able to reproduce observed behaviour in response to various stimuli.

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Section: Resultssupporting

confidence: 88%

“…Obtaining the qualitative behaviour shown in Figure 9 , the quantitative match in Figure 10 , and the qualitative behaviour during functional activation in [5] and [24] was achieved by varying the six model parameters which control the response of reaction rates to Δp: i.e. Δp 30 , c 3, c k 1 , c k 2 , L CV ,0 , r CV and Δp CV 0 .…”

Section: Resultsmentioning

confidence: 99%

A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges

Banaji

Mallet²,

Elwell³

et al. 2008

PLoS Comput Biol

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“…In our studywhere head movement was minimized -, CBSI proved even more effective in eliminating hemodynamic components with a correlating impact on HbO and HbR signals. However, it has been shown that various means of cognitive stimulation, such as mental arithmetic [52,53] or anagram based tests [46], speech tasks [54]-but in fact, even simple motor tasks such as finger opposition [55]-can elicit not only regional but systemic response as well. These changes in heart rate, mean arterial pressure or partial pressure of CO 2 , by altering cerebral blood flow, can affect HbO and HbR concentrations in an anticorrelating manner albeit with smaller amplitude [14].…”

Section: Discussionmentioning

confidence: 99%

Increased prefrontal cortex connectivity during cognitive challenge assessed by fNIRS imaging

Racz

Mukli

Nagy

et al. 2017

Biomed. Opt. Express

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In this study, functional near-infrared spectroscopy (fNIRS) and the graph theory approach were used to access the functional connectivity (FC) of the prefrontal cortex (PFC) in a resting state and during increased mental workload. For this very purpose, a pattern recognition-based test was developed, which elicited a strong response throughout the PFC during the test condition. FC parameters obtained during stimulation were found increased compared to those in a resting state after correlation based signal improvement (CBSI), which can attenuate those components of fNIRS signals which are unrelated to neural activity. These results indicate that the cognitive challenge increased the FC in the PFC and suggests a great potential in investigating FC in various cognitive states.

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“…However in certain functional OT experiments these assumptions are not accurate. Using two channels near-infrared spectroscopy (NIRS) Leung and colleagues found a relatively high correlation between Δ[HbO 2 ] signals over the frontal cortex (FC) and motor cortex (MC) during finger tapping while also observing a significant increase in heart rate (HR)[1]. In a study in 2008, we have observed significant task related changes in mean blood pressure (MBP) and HR during anagram solving and in some volunteers the Δ[HbO 2 ] and Δ[HHb] signals measured over the activated FC were correlated with the MBP signal [2].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis

Patel

Katura

Maki

et al. 2011

Oxygen Transport to Tissue XXXII

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Functional near-infrared optical topography (OT) is used to non-invasively measure the changes in oxygenated and deoxygenated haemoglobin (Δ[HbO2], Δ[HHb]) and hence investigate the brain haemodynamic changes, which occur in response to functional activation at specific regions of the cerebral cortex. However, when analysing functional OT data the task-related systemic changes should be taken into account. Here we used an independent component analysis (ICA) method on the OT [HbO2] signal, to determine the task related independent components and then compared them with the systemic measurements (blood pressure, heart rate, scalp blood flow) to assess whether the components are due to systemic noise or neuronal activation. This analysis can therefore extract the true OT haemodynamic neuronal response and hence discriminate between regional activated cortical areas and global haemodynamic changes.

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Simultaneous Measurement of Cerebral Tissue Oxygenation over the Adult Frontal and Motor Cortex During Rest and Functional Activation

Cited by 5 publications

References 9 publications

A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges

A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges

Increased prefrontal cortex connectivity during cognitive challenge assessed by fNIRS imaging

Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis

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