Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation

Cho, Chun‐Seok; Kim, Yongsung; Park, Sung-Rye; Kim, Boyoung; Davis, Carol; Hwang, Irene; Brooks, Susan V.; Lee, Jun H.; Kim, Myung-Jin

doi:10.1080/15548627.2021.2016255

Cited by 6 publications

(1 citation statement)

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“…Simultaneous activation of both RHEB and RAG via muscle-specific Tsc1/Depdc5-double knockout can lead to early-onset myopathy associated with excessive mitochondrial oxidative stress. They also showed cardiovascular defects and early fatality, further emphasizing the role of mTORC1 in mediating mitochondrial function and maintaining homeostasis [78].…”

Section: Signaling Factorsmentioning

confidence: 99%

The Molecular Mechanisms of Fuel Utilization during Exercise

Pi,

Villivalam,

Kang

2023

Biology

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Exercise is widely recognized for its positive impact on human health and well-being. The process of utilizing substrates in skeletal muscle during exercise is intricate and governed by complex mechanisms. Carbohydrates and lipids serve as the primary fuel sources for skeletal muscle during exercise. It is now understood that fuel selection during exercise is not solely determined by physical activity itself but is also influenced by the overall metabolic state of the body. The balance between lipid and carbohydrate utilization significantly affects exercise capacity, including endurance, fatigue, and overall performance. Therefore, comprehensively understanding the regulation of substrate utilization during exercise is of utmost importance. The aim of this review is to provide an extensive overview of the current knowledge regarding the pathways involved in the regulation of substrate utilization during exercise. By synthesizing existing research, we can gain a holistic perspective on the intricate relationship between exercise, metabolism, and fuel selection. This advanced understanding has the potential to drive advancements in the field of exercise science and contribute to the development of personalized exercise strategies for individuals looking to optimize their performance and overall health.

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Section: Signaling Factorsmentioning

confidence: 99%