Simultaneous Living Donor Kidney and Parathyroid Allotransplantation

Garcia-Roca, Raquel; Garcia‐Aroz, Sandra; Tzvetanov, Ivo; Giulianotti, Pier Cristoforo; Campara, Maya; Oberholzer, José; Benedetti, Enrico

doi:10.1097/tp.0000000000001042

Cited by 21 publications

(21 citation statements)

References 18 publications

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“…A young female with end-stage renal disease due to nephrocalcinosis secondary to congenital absence of parathyroid tissue received a simultaneous renal and single parathyroid transplantation from her sister. Three days following the operation, the patient demonstrated detectable levels of PTH, and the graft remained functional at 9 months post-op [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Patients’ views about parathyroid transplantation for post-thyroidectomy hypoparathyroidism

Schmeißer

Mihai

2018

Langenbecks Arch Surg

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BackgroundPermanent hypoparathyroidism (hypoPT) represents the most common postoperative complication associated with total thyroidectomy. Current treatment relies on high-dose calcium and/or vitamin D supplementation, but often this is insufficient and some patients remain symptomatic. Parathyroid allotransplantation is a new therapeutic option described recently in the literature. This study aims to investigate the patients’ acceptability of parathyroid transplantation as a potential new treatment for hypoPT.MethodOnline survey of members of HypoParaUK, a support group for individuals affected by hypoPT.ResultsResponses were received from 252 hypoPT patients. Majority declared to experience severe symptoms despite regular medical treatment. On a severity scale of 0–5, symptoms that were most troublesome were fatigue (3.8), low sense of well-being (3.5), and numbness/tingling (2.9). On a scale of 0–10, on average, their current quality of life (QoL) was 5 ± 3 and they expected this would improve to 7 ± 2 with correction of their hypoPT. Forty-four percent of patients were extremely interested in a potential technique involving intramuscular injection of parathyroid cell suspension compared to just 14% who were interested in the more invasive procedure of implantation of a parathyroid allograft into the forearm. The main concerns expressed were related to the possible need for immunosuppressive therapy.ConclusionPatients with severe symptomatic hypoPT seem interested to consider participation in a clinical trial exploring the feasibility and success rate of parathyroid transplantation.Electronic supplementary materialThe online version of this article (10.1007/s00423-018-1693-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Patients’ views about parathyroid transplantation for post-thyroidectomy hypoparathyroidism

Schmeißer

Mihai

2018

Langenbecks Arch Surg

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“…Paratiroit nakli için de henüz standart kriterler belirlenmemiş olsa da bu uyumun önem taşıdığı düşünülmektedir. Literatürde daha önce başka organlarla eş zamanlı olarak gerçekleştirilen paratiroit nakillerinde alıcı-donör uyumunun diğer majör organa göre belirleniyor oluşu (immünsupresyon rejimi, immünolojik izlem parametreleri gibi) paratiroit nakline ait parametrelerin belirlenmesi için yeterli olmamaktadır (10)(11)(12)(13)(14).…”

Section: Bulgular Ve Tartişmaunclassified

Parati̇roi̇t Nakli̇ Bekleyen Hi̇poparati̇roi̇di̇ Hastalarinin Naki̇l Bekleme Süreleri̇ni̇n Değerlendi̇ri̇lmesi̇

Salepcioğlu¹,

Göncü²,

Karatoprak³

et al. 2021

JOHSE

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“…There has been several successful cases of simultaneous kidney and parathyroid allotransplants -one in a patient with postsurgical hypoparathyroidism related to ESRD [36] and one in a patient with congenital hypoparathyroidism complicated by nephrolithiasis and subsequent renal failure [37]. Successful parathyroid allotransplantation for hypoparathyroidism represents a novel strategy that could provide the definitive treatment for patients with difficult to control hypoparathyroidism.…”

Section: Parathyroid Gland Transplantationmentioning

confidence: 99%

Hypoparathyroidism – Review of the Literature 2018

Sinnott¹

2018

J Rare Disord Diagn Ther

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options available for chronic hypoparathyroidism included calcium supplements, activated vitamin D and thiazide diuretics. In the last few years recombinant human (rh) PTH (1-84) has been approved for the treatment of hypoparathyroidism and is a useful therapeutic option for patients with suboptimal calcium levels despite high dose calcium and activated vitamin D. In this paper, we will review hypoparathyroid pathophysiology, epidemiology, etiologies, diagnosis, clinical features, conventional treatment options, as well as recent advancement in treatment options available to date.

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Simultaneous Living Donor Kidney and Parathyroid Allotransplantation

Cited by 21 publications

References 18 publications

Patients’ views about parathyroid transplantation for post-thyroidectomy hypoparathyroidism

Patients’ views about parathyroid transplantation for post-thyroidectomy hypoparathyroidism

Parati̇roi̇t Nakli̇ Bekleyen Hi̇poparati̇roi̇di̇ Hastalarinin Naki̇l Bekleme Süreleri̇ni̇n Değerlendi̇ri̇lmesi̇

Hypoparathyroidism – Review of the Literature 2018

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