Simultaneous LC Estimation of Glimepiride and Metformin in Glimepiride Immediate Release and Metformin Sustained Release Tablets

Pawar, Shraddha; Meshram, Gangadhar A.; Phadke, Manisha

doi:10.1365/s10337-008-0802-4

Cited by 21 publications

(10 citation statements)

References 5 publications

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“…8 There are two polymorphs of this molecule reported in the literature, form I and form II, of which form II has about 3.5-fold higher solubility than that of form I. 9 There is a growing number of studies describing the determination of glimepiride concentration in biological fluids [10][11][12][13][14][15][16][17][18] and pharmaceutical formulations [19][20][21][22][23][24][25][26][27][28][29][30] using a variety of methods. However, there is no dissolution method for glimepiride tablets in the literature.…”

Section: Introductionmentioning

confidence: 99%

A Discriminating Dissolution Method for Glimepiride Polymorphs

Bonfílio

Pires

Ferreira

et al. 2012

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

A Discriminating Dissolution Method for Glimepiride Polymorphs

Bonfílio

Pires

Ferreira

et al. 2012

Journal of Pharmaceutical Sciences

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“…Several different methods have been reported for qualitative and quantitative analysis of glimepiride; these include micellar electrokinetic capillary chromatography (MECC) with diode-array detection (DAD) or ultraviolet (UV) detection, high performance liquid chromatography (HPLC) with DAD and UV detection and derivative UV Spectrophotometric detection 3,4 , liquid chromatography-electrospray ionization mass spectrometry (LC-ESI/MS) [5][6][7][8] , an HPLC method for the quantification of glimepiride in single dose formulation [9][10][11] , in human plasma [12][13] , the quantification of cis-isomer of glimepiride by normal phase chromatography 14 .A simple accurate and precise HPLC method has been developed for estimation of glimepiride in single dosageform.…”

Section: Figure 1: Glimepiridementioning

confidence: 99%

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2013

IJPSR

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An accurate, sensitive and precise RP-HPLC method has been developed and validated for the estimation of Glimepiride (GLM) from bulk drug and Pharmaceutical Dosage form. The separation was achieved by Hypersil C18 column (250mm X 4.6mm, 5μm) in isocratic mode, with mobile phase comprises of Acetonitrile : Buffer in proportion of 60:40v/v, buffer was 0.02M Potassium Di-hydrogen Phosphate (pH 4.5 adjusted with Ortho Phosphoric Acid). The flow rate of mobile phase was 1.0ml/min and employing UV detection with 232nm wavelengths. The retention time of GLM was 5.420 min.The calibration curve was found to be linear within the concentration range of 50µg/ml to 150µg/ml. The regression data for calibration curve shows good linear relationship with r 2 = 0.9965. The method was validated in accordance with the requirements of ICH guidelines. Moreover, the proposed analytical method was applied to monitor the formulation commercially available.

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“…ese three drugs are also available in the market as a combination, dosage forms. For individual estimation of each drug, several methods are available in the literature [3][4][5][6][7] even there are couple of methods available for estimation of two drugs at a time [8][9][10][11][12][13][14]. ere are some methods where even more than 2 drugs are estimated at a time [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

RP‐HPLC Analytical Method Development and Validation for Simultaneous Estimation of Three Drugs: Glimepiride, Pioglitazone, and Metformin and Its Pharmaceutical Dosage Forms

Nirupa

Tripathi²

2012

Journal of Chemistry

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Developing a single analytical method for estimation of individual drug from a multidrug composition is a very challenging task. A simple, rapid, precise, and reliable reverse phase HPLC method was developed for the separation and estimation of three drugs glimepiride, pioglitazone and metformin in bulk drug mix and pharmaceutical dosage forms. The estimation was carried out using Inertsil ODS-3V (250 mm × 4.6 mm, 5 μm) column; mobile phase consisting of acetonitrile, tetrahydrofuran, and buffer at pH 5; the flow rate of 1.7 mL/min and ultraviolet detection at 228 nm. All the three drugs were properly resolved having run time of 5 minutes, 3.9 minutes and 1.3 minutes for glimepiride, pioglitazone, and metformin, respectively. The method was validated as a final verification of method development with respect to precision, linearity, accuracy, ruggedness, and robustness. The validated method was successfully applied to the commercially available pharmaceutical dosage form, yielding very good and reproducible result.

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Simultaneous LC Estimation of Glimepiride and Metformin in Glimepiride Immediate Release and Metformin Sustained Release Tablets

Cited by 21 publications

References 5 publications

A Discriminating Dissolution Method for Glimepiride Polymorphs

A Discriminating Dissolution Method for Glimepiride Polymorphs

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RP‐HPLC Analytical Method Development and Validation for Simultaneous Estimation of Three Drugs: Glimepiride, Pioglitazone, and Metformin and Its Pharmaceutical Dosage Forms

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