Simultaneous kinetic-photometric determination of imipramine and desipramine by stopped-flow mixing technique

Peña, L. de la; Gómez‐Hens, A.; Pérez‐Bendito, Dolores

doi:10.1016/0003-2670(93)85258-l

Cited by 7 publications

(1 citation statement)

References 15 publications

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“…The simultaneous determination of analytes using kinetic methods has proven most useful in applications where separations are unsuccessful in resolving mixtures whose components are chemically very similar (3)(4)(5), such as catecholamines (6) or drugs and their metabolites (7,8). Chemiluminescence measurements involving luminol (2,9), lucigenin (10,11) and lophine (12) have been used in such multicomponent analyses.…”

Section: Introductionmentioning

confidence: 99%

Stopped-flow analysis of Ru(bpy)33+chemiluminescent reactions

Shultz

Nieman

1998

J. Biolumin. Chemilumin.

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The stopped-flow technique was employed to measure chemiluminescent emission from the reaction of a mixture of oxalate and proline with a chemiluminescence reagent, tris(2,2'-bipyridine) ruthenium(III), or Ru(bpy)3(3+) is a versatile reagent and is often used in bioanalytical applications, including the detection of certain drugs and their metabolites, for example. Unfortunately, Ru(bpy)3(3+) has not yet been fully examined as a possible chemiluminescence reagent for simultaneous kinetic determinations. In this work, a differential reaction rate method, based on simple least squares regressions of the pseudo-first order decay data, was used to resolve two compounds, oxalate and proline, reacting simultaneously with Ru(bpy)3(3+). Our results indicate that stopped-flow analyses with Ru(bpy)3(3+) could provide a viable method for simultaneous determinations of unresolvable analytes of environmental and pharmaceutical importance.

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