Simultaneous injection of hepatitis B vaccine with BCG and killed poliovirus vaccine

Coursaget, Pierre; Relyveld, E. H.; Brizard, A.; Frenkiel, Marie-Pascale; Fritzell, Bernard; Teulières, L.; Bourdil, C.; Yvonnet, B; Jeannée, Emile; Guindo, S.; Chiron, J.P.; Diop-Mar, I.

doi:10.1016/0264-410x(92)90370-y

Cited by 21 publications

(4 citation statements)

References 5 publications

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“…163,164 However, there is currently insufficient robust data to draw firm conclusions: for detailed analysis please see WHO draft protocols of clinical trials to assess the non-specific effects of vaccines 165 and Higgins et al 166 In a study examining antibody response to hepatitis B surface antigen (HBsAg) in 60 infants in Turkey 167 , simultaneous administration of BCG and hepatitis B vaccines did not influence the immune response to HBsAg when compared to administration of hepatitis B vaccine alone. This finding aligns with an older study in Senegal 168 , which also showed that the serological response to HBsAg and poliovirus and cellular response to BCG did not differ between simultaneous administration of hepatitis B, BCG and oral polio vaccine (tOPV) vaccines compared to separate administration groups. One study in India found that BCG vaccine given first followed by hepatitis B vaccination caused less pain, as assessed by the neonatal infant pain scale, than the other order and thus recommends this order of administration.…”

Section: Co-administration With Other Vaccinessupporting

confidence: 90%

Two Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guérin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing <2000 g in India

Kumutha

Adhisivam

Nallasivan

et al. 2019

Pediatric Infectious Disease Journal

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List of abbreviations AFR. african region AMR. antimicrobial resistances BCG. bacillus calmette-guérin BUD. buruli ulcera disease CFU. colony forming units DHS. demographic health surveys DRDR. drug resistance determining regions DSJI. disposable-syringe jet injectors DST. drug susceptibility testing EID. early infant HIV diagnosis EMR. eastern mediterranean region EUR. european region G2D. grade-2 disabilities GLP. global leprosy programm GTB. global TB programme HBsAg. hepatitis B surface antigen HCWs. health care workers HICs. high income countries IRIS. immune reconstitution inflammatory syndrome IUATLD. international union against TB and lung disease JRF. WHO/UNICEF Joint Reporting LBW. low birth weight LICs. low income countries LMICs. lower-middle income countries MB. multi-bacillary MDGs. millennium development goals MDR-TB. multidrug-resistant TB MDT. multi-drug therapy, multidrug therapy MICs. middle income countries MICS. multiple indicator cluster surveys MOTT. mycobacteria other than tuberculosis NRA. national regulatory authority NS. needle and syringe NTM. non-tuberculous mycobacterial OPV. oral polio vaccine PB. pauci-bacillary PEP. post-exposure prophylaxis PMTCT. prevention of mother to child transmission POC. point-of-care PQ'd. prequalified PTB. pulmonary tuberculosis R&D. research and development SAGE. strategic advisory group of experts on immunization SDGs. sustainable development goals SEAR. south east asian region TB. tuberculosis UHC. universal health coverage VENICE. vaccine european new integrated collaboration effort WPR. western pacific region WUENIC. WHO/UNICEF estimates of national immunization Coverage XDR-TB. extensively drug-resistant TB

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Section: Co-administration With Other Vaccinessupporting

confidence: 90%

Two Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guérin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing <2000 g in India

Kumutha

Adhisivam

Nallasivan

et al. 2019

Pediatric Infectious Disease Journal

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“…No impairment in the expected protective efficacy was noted when HBV was administered with: BCG and IPV,4diphtheria-tetanus (DT) and diphtheria-tetanus-pertussis (DTP),22 OPV,22-24 group A meningococcus vaccine,25 measles vaccine,26 Japanese B encephalitis vaccine,26 and hepatitis A vaccine 2728 Our study is the first to investigate early simultaneous HBV and IPV vaccination in preterm infants.…”

Section: Discussionmentioning

confidence: 93%

“…Concomitant administration of HBV and IPV has been shown to be effective in full term infants,4 but there are no studies in preterm infants.…”

mentioning

confidence: 99%

Controlled trial of immune response of preterm infants to recombinant hepatitis B and inactivated poliovirus vaccines administered simultaneously shortly after birth

Linder

Handsher²,

German³

et al. 2000

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Aim-The study was conducted to evaluate the immunogenicity of an early, extra dose of enhanced inactivated poliovirus vaccine (IPV) administered simultaneously with recombinant hepatitis B vaccine (HBV) to preterm infants shortly after birth. Methods-Three groups were studied. Fifty preterm infants received IPV intramuscularly within 24 hours of birth, in addition to routine recommended childhood immunisations. Fifty two preterm infants and 35 full term infants received routine immunisations only (routine vaccination timing: HBV at birth, 1 and 6 months of age; IPV at 2 and 4 months; oral polio vaccine (OPV) at 4 and 6 months; diphtheria-tetanus-pertussis (DTP) at 2, 4, and 6 months; and Haemophilus influenzae B vaccine at 2 and 4 months). Blood samples were taken at birth, 3 and 7 months of age from all infants, and at 1 month of age from preterm infants only. Results-At birth, a lower percentage of both study and control preterm infants had antipoliovirus type 3 titres > 1:8 than full term infants. At 1 and 3 months of age significantly more early IPV infants had antipoliovirus type 3 titres > 1:8 than routinely vaccinated preterm infants (p < 0.05). At 7 months of age there were no significant diVerences in percentage of antipoliovirus titres > 1:8 or geometric mean times (GMTs) between the early IPV group and the routinely vaccinated preterm group. At 3 and 7 months of age, the percentage of positive antihepatitis B titres (> 1:10) and the GMT of the early IPV preterm group did not diVer significantly from those of preterm controls. There was no significant diVerence in percentage of positive antihepatitis B titres between the early IPV group and full term controls at any time. GMTs for hepatitis B antibodies were significantly lower in the early IPV preterm group than in full term controls at 3 and 7 months of age. Conclusions-Administration of an additional dose of IPV simultaneously with routine HBV to preterm infants shortly after birth provides early protection from poliovirus and hepatitis B infection, and does not interfere with poliovirus antibody production at the age of 7 months.

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“…Efficacy is optimal when the vaccine is administered within 12–24 hours after birth but declines over next 24 hours and thereafter. The universally agreed recommendation for birth dose is “as soon as possible after birth” (preferably within 24 hours) [57–61]. …”

Section: Prevention Of Mother To Child Transmission (Mtct)mentioning

confidence: 99%

HBV Perinatal Transmission

Umar

Hamama-tul-Bushra

Umar

et al. 2013

International Journal of Hepatology

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Simultaneous injection of hepatitis B vaccine with BCG and killed poliovirus vaccine

Cited by 21 publications

References 5 publications

Two Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guérin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing <2000 g in India

Two Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guérin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing <2000 g in India

Controlled trial of immune response of preterm infants to recombinant hepatitis B and inactivated poliovirus vaccines administered simultaneously shortly after birth

HBV Perinatal Transmission

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