Simultaneous imaging of lysosomal and mitochondrial viscosity under different conditions using a NIR probe

Wei, Yu-Fang; Weng, Xiao-Feng; Sha, Xin-Long; Sun, Rong; Xu, Yu-Jie; Ge, Jian‐Feng

doi:10.1016/j.snb.2020.128954

Cited by 54 publications

(23 citation statements)

References 30 publications

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“…The abnormal viscosity of the mitochondria and lysosomes can lead to their dysfunction and eventually to the development of related diseases ( Lu et al, 2013 ; Bochao et al, 2019 ). Wei et al (2021) had developed a cyanine compound in 2020 for the detection of medium viscosity. The probe had near-infrared emission (650 nm) and improved sensitivity and selectivity.…”

Section: Dual-labeling Probes Targeting Lysosomes and Mitochondriamentioning

confidence: 99%

Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes

Chen

Ren

et al. 2022

Front. Pharmacol.

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Modern cellular biology faces several major obstacles, such as the determination of the concentration of active sites corresponding to chemical substances. In recent years, the popular small-molecule fluorescent probes have completely changed the understanding of cellular biology through their high sensitivity toward specific substances in various organisms. Mitochondria and lysosomes are significant organelles in various organisms, and their interaction is closely related to the development of various diseases. The investigation of their structure and function has gathered tremendous attention from biologists. The advanced nanoscopic technologies have replaced the diffraction-limited conventional imaging techniques and have been developed to explore the unknown aspects of mitochondria and lysosomes with a sub-diffraction resolution. Recent progress in this field has yielded several excellent mitochondria- and lysosome-targeted fluorescent probes, some of which have demonstrated significant biological applications. Herein, we review studies that have been carried out to date and suggest future research directions that will harness the considerable potential of mitochondria- and lysosome-targeted fluorescent probes.

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Section: Dual-labeling Probes Targeting Lysosomes and Mitochondriamentioning

confidence: 99%

Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes

Chen

Ren

et al. 2022

Front. Pharmacol.

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“…This feature is essential for the molecular probes to be selectively sensitive to the cellular microenvironment viscosity. [29][30][31][32] The viscosity sensitivity of the probes was first investigated. Then, various solutions with different levels of viscosity in a water-glycerol system were also analysed.…”

Section: Response To Viscositymentioning

confidence: 99%

Two-photon fluorescence imaging of mitochondrial viscosity with water-soluble pyridinium inner salts

et al. 2022

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“…[5][6][7][8] In addition, some diseases such as cancer and Alzheimer's disease have been authenticated to be related to polarity and viscosity. [9][10][11][12] Lipid droplets are the main storage sites for intracellular lipids. Abnormal lipid droplet polarity is inextricably linked with many pathological processes according to previous studies.…”

Section: Introductionmentioning

confidence: 99%