Simultaneous Identification of Vitamins B1, B3, B5, and B6 by an Engineered Nanopore
Yusheng Ouyang,
Kefan Wang,
Wendong Jia
et al.
Abstract:Vitamin Bs, a group of water-soluble compounds, are essential nutrients for almost all living organisms. However, due to their structural heterogeneity, rapid and simultaneous analysis of multiple vitamin Bs is still challenging. In this paper, it is discovered that a hetero-octameric Mycobacterium smegmatis porin A (MspA) nanopore containing a sole nickel ion-bound nitrilotriacetic acid (NTA-Ni) adapter at its pore constriction is suitable for the simultaneous sensing of different vitamin Bs, including vitami… Show more
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