Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals

Characterization of new topical ketoprofen formulations prepared by drug entrapment in solid lipid matrices

“…In this case, it should be pointed out that ketoprofen is unstable, especially in solution, and it might undergo degradation by the effect of light and moisture. The active agent is first transformed into 3‐acetylbenzophenone that subsequently leads to 2‐(3‐carboxyphenyl)propionic acid 28. These decomposition products may appear occasionally in the samples.…”

“…Recently, various chromatographic methods with spectroscopic or mass spectrometric detection have been proposed for the determination of ketoprofen in pharmaceutical samples 26–30. Some alternative techniques such as capillary electrophoresis with zone or electromicellar modes,31,32 ultra‐sensitive luminescence based on signal enhancement with Tb(III),33 and flow injection analysis have also been utilized 34…”

High-performance liquid chromatography analysis of anti-inflammatory pharmaceuticals with ultraviolet and electrospray-mass spectrometry detection in suspected counterfeit homeopathic medicinal products

“…Preliminary UV analyses were performed at different wavelengths as specified in literature for each active substance [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. This was done to select the appropriate wavelength for all pharmaceuticals in order to utilise a single wavelength detector.…”

“…Among them gas chromatography-mass spectrometry (GC-MS) [12][13][14][15][16][17] has been extensively utilised even though it often requires analyte derivatisation. HPLC is fast, sensitive and has also been utilised with UV [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] and with fluorescence [36,37] detection. Capillary electrophoresis (CE) [38,39] and CE-MS [40,41] have also been utilised.…”

Formulation and characterization of dissolvable microneedles for controlled transdermal delivery of ketoprofen encapsulated in polymeric nanoparticles

“…Razvoj metode započet je na osnovu literaturnih podataka za hromatografske uslove određivanja ketoprofena (145,159). Inicijalne analize su rađene korišćenjem mobilne faze čiji sastav su činili različiti odnosi acetonitrila i vode, i praćeno je nekoliko osnovnih hromatografskih parametara (simetrija pika, retenciono vrijeme).…”