Simultaneous GLC Analysis of Aspirin and Nonaspirin Salicylates in Pharmaceutical Tablet Formulations

Galante, Robert N.; Egoville, John C.; Visalli, Anthony J.; Patel, Dahyabhai M.

doi:10.1002/jps.2600700213

Cited by 16 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GC/FID was used to separate and detect aspirin and salicylic acid. Galante et al (11) performed a silylation using BSTFA to form the trimethylsilyl derivatized species of aspirin and salicylic acid from tablet formulations. GC/FID was used to separate and detect aspirin and salicylic acid.…”

Section: Introductionmentioning

confidence: 99%

Trimethylsilyl Derivatization and Gas Chromatograph–Mass Spectrometric Determination of Aspirin and Its Major Metabolites, I

Mongillo

Paul

1997

Microchemical Journal

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Trimethylsilyl Derivatization and Gas Chromatograph–Mass Spectrometric Determination of Aspirin and Its Major Metabolites, I

Mongillo

Paul

1997

Microchemical Journal

View full text Add to dashboard Cite

“…These methods have employed partition chromatographic (Levine & Weber 1968;Guttman & Salomon 1969), gas liquid chromatography (Galante et al 1981), liquid chromatography (Baum & Cantwell 1978 This paper reports a simple, rapid and accurate method for the direct determination of salicylic acid in ASA by second derivative u.v.-spectrophotometry. The effect of drum rotational speed on material carryover and process efficiency (solids application rate 7.30 g min-1, charge 10 kg).…”

mentioning

confidence: 99%

Determination of salicylic acid in acetylsalicylic acid by second derivative u. v.-spectrophotometry

Mazzeo

Quaglia

1982

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

COMMUNICATIONSTable 2. The effect of drum rotational speed on material carryover and process efficiency (solids application rate 7.30 g min-1, charge 10 kg). Drum rotation speed rev min-1 12 15 20 24 Material carryover % 1.81 1.85 2-13 2.21 Processefficiency % 98.2 98.1 97.9 97.8These results have important practical implications in the film coating of solid dosage forms and are particularly relevant to sustained release products where the drug release rate is dependent on, inter alia, the thickness and the uniformity of the film coating. In this case increasing the drum rotational speed may well be detrimental since, although improving mixing of the tablet bed, it may well result in increased carryover and decreased film thickness. The results illustrate the potential of this accurate, rapid and simple technique of isokinetic sampling of the exhaust duct in the optimization of process conditions during product development. Table 3. The effect of charge size on material carryover and, process efficiency (solids application rate 7.30 g min-l, drum speed 16 rev min-1). Charge size kg 6 10 12 Material carryover % 3.25 1.85 1.82 Process efficiency % 96.7 98.1 98.2

show abstract

“…Methods reported for the determination of SA including: spectrophotometric [4][5][6][7][8][9], spectrofluorimetric [10][11][12][13], colorimetric [14][15][16], liquid membrane electrodes [17][18], immunoassays [19][20], amperometric [211, chromatographic [22][23][24][25], enzymatic methods [26] and high performance liquid chromatography (HPLC) [27]. Even though gasliquid chromatography is sensitive, it requires prior extraction and silyl-type derivatisation [28].…”

Section: Introductionmentioning

confidence: 99%

“…Optical fibre spectrophotometric method was used in this study for SA determination due to the simplicity and low cost of this method compared with conventional methods such as HPLC [27] and other chromatographic methods [22][23][24][25]. Sensors have advantages like low in cost, shorter response time and need no professional technicians if compared with conventional methods [29].…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Characterisation and Optimisation of Novel Salicylic Acid Sensors Using Different Reagents and Artificial Neural Network

Loh

Ahmad²,

Taib

2005 Asian Conference on Sensors and the International Conference on New Techniques in Pharmaceutical and Biomedical Research

View full text Add to dashboard Cite

Two optical fiber chemical sensors for salicylic acid (SA) have been fabricated using ferric(III) nitrate and copperQl) nitrate as reagent. Ion exchange resin, Dowex 50x8 had been used as solid support and optimisation was done by using artificial neural network (ANN). SA sensor using immobilised Fe(III) gave maximum reflectance at wavelength of 786 nm and pH 2.1. Dynamic range of SA concentration had been extended using ANN (15 hidden neurons) from 0.02 -0.50 g/L to 0.02 -2.00 g/L. SA sensor based on immobilised Cu(Ii) showed maximum reflectance at pH 6.5 and wavelength of 725 nm. ANN with 5 hidden neurons was able to extend dynamic range of SA concentration from 0.40 -1.40 g/L to 0.05 -2.00 g/L. Sumsquared error (SSE) for SA sensor based on Fe(III) and Cu(I) were 0.0140 g/L and 0.0310g/L, respectively. These two sensors were stable for a period ofmore than 24 hours.

show abstract

Simultaneous GLC Analysis of Aspirin and Nonaspirin Salicylates in Pharmaceutical Tablet Formulations

Cited by 16 publications

References 41 publications

Trimethylsilyl Derivatization and Gas Chromatograph–Mass Spectrometric Determination of Aspirin and Its Major Metabolites, I

Trimethylsilyl Derivatization and Gas Chromatograph–Mass Spectrometric Determination of Aspirin and Its Major Metabolites, I

Determination of salicylic acid in acetylsalicylic acid by second derivative u. v.-spectrophotometry

Fabrication, Characterisation and Optimisation of Novel Salicylic Acid Sensors Using Different Reagents and Artificial Neural Network

Contact Info

Product

Resources

About