Simultaneous fluoroscopic and nuclear imaging: impact of collimator choice on nuclear image quality

Velden, Sandra van der; Beijst, Casper; Viergever, Max A.; Jong, Hugo W. A. M. de

doi:10.1002/mp.12010

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…The authors propose a hybrid imaging system, consisting of an X-ray c-arm combined with gamma imaging capabilities for simultaneous real-time fluoroscopic and nuclear imaging. A slightly modified version of this prototype [ 123 ] was shown to be able to accurately estimate LSF of a 99m Tc-MAA scout dose in an interventional setting [ 124 ]. When this hybrid imaging modality becomes available in the angiography room, it may be possible to move towards 1-day procedures by combining scout and therapy dose in one session.…”

Section: Reviewmentioning

confidence: 99%

The physics of radioembolization

et al. 2018

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Radioembolization is an established treatment for chemoresistant and unresectable liver cancers. Currently, treatment planning is often based on semi-empirical methods, which yield acceptable toxicity profiles and have enabled the large-scale application in a palliative setting. However, recently, five large randomized controlled trials using resin microspheres failed to demonstrate a significant improvement in either progression-free survival or overall survival in both hepatocellular carcinoma and metastatic colorectal cancer. One reason for this might be that the activity prescription methods used in these studies are suboptimal for many patients.In this review, the current dosimetric methods and their caveats are evaluated. Furthermore, the current state-of-the-art of image-guided dosimetry and advanced radiobiological modeling is reviewed from a physics’ perspective. The current literature is explored for the observation of robust dose-response relationships followed by an overview of recent advancements in quantitative image reconstruction in relation to image-guided dosimetry.This review is concluded with a discussion on areas where further research is necessary in order to arrive at a personalized treatment method that provides optimal tumor control and is clinically feasible.

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Section: Reviewmentioning

confidence: 99%

The physics of radioembolization

et al. 2018

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“…Our hybrid imaging device is extensively described and evaluated for physical performance earlier (Beijst et al 2015, van der Velden et al 2017, including the hardware and algorithms that are applied to generate a real time, simultaneous hybrid planar image. In short, four gamma cameras are symmetrically placed around the x-ray tube, hence creating stereoscopic views of the FOV without blocking the line of sight of the x-ray modality (figure 1) (Beijst et al 2015).…”

Section: Device Designmentioning

confidence: 99%

“…To this end, a real-time, simultaneous fluoroscopic and nuclear imaging device is currently being developed by our group, consisting of a c-arm combined with four gamma cameras (figure 1) (Beijst et al 2015, van der Velden et al 2017. This set-up enables simultaneous acquisition of fluoroscopic and nuclear images of the same field-of-view (FOV), thereby creating overlapping hybrid images in both the spatial and the temporal domain.…”

Section: Introductionmentioning

confidence: 99%

Estimation of lung shunt fraction from simultaneous fluoroscopic and nuclear images

et al. 2017

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“…In the design of Beijst et al (2) and van der Velden et al (3), four g cameras with pinhole collimators were positioned at the side of the x-ray tube. Although the prototype showed that interventional hybrid imaging was feasible, this design required an intermediate reconstruction step and additional weight added to the already heavy x-ray tube.…”

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A Dual-layer Detector for Simultaneous Fluoroscopic and Nuclear Imaging

et al. 2019

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Content codes:Purpose: To develop and evaluate a dual-layer detector capable of acquiring intrinsically registered real-time fluoroscopic and nuclear images in the interventional radiology suite. Materials and Methods:The dual-layer detector consists of an x-ray flat panel detector placed in front of a g camera with cone beam collimator focused at the x-ray focal spot. This design relies on the x-ray detector absorbing the majority of the x-rays while it is more transparent to the higher energy g photons. A prototype was built and dynamic phantom images were acquired. In addition, spatial resolution and system sensitivity (evaluated as counts detected within the energy window per second per megabecquerel) were measured with the prototype. Monte Carlo simulations for an improved system with varying flat panel compositions were performed to assess potential spatial resolution and system sensitivity. Results:Experiments with the dual-layer detector prototype showed that spatial resolution of the nuclear images was unaffected by the addition of the flat panel (full width at half maximum, 13.6 mm at 15 cm from the collimator surface). However, addition of the flat panel lowered system sensitivity by 45%-60% because of the nonoptimized transmission of the flat panel. Simulations showed that an attenuation of 27%-35% of the g rays in the flat panel could be achieved by decreasing the crystal thickness and housing attenuation of the flat panel.

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Simultaneous fluoroscopic and nuclear imaging: impact of collimator choice on nuclear image quality

Cited by 9 publications

References 28 publications

The physics of radioembolization

The physics of radioembolization

Estimation of lung shunt fraction from simultaneous fluoroscopic and nuclear images

A Dual-layer Detector for Simultaneous Fluoroscopic and Nuclear Imaging

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