Simultaneous fluorometric measurement of histamine and tele-methylhistamine levels in rodent brain by high-performance liquid chromatography

Miyamoto, Y.; Yoshimoto, Ryo; Yumoto, Mariko; Ishihara, Akane; Takahashi, Kazuhiko; Kotani, Hidehito; Kanatani, Akio; Tokita, Shigeru

doi:10.1016/j.ab.2004.07.016

Cited by 18 publications

(11 citation statements)

References 29 publications

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“…The method was based on post‐column o ‐phthalaldehyde/β‐mercaptoethanol derivatization as described in detail in Miyamoto et al . (). The supernatants of precipitated samples collected as described above were neutralized with 10 volumes of 0.4 m borate buffer.…”

Section: Methodsmentioning

confidence: 97%

“…The assay used here was a combination of methods for the simultaneous determination of histamine and 1‐methylhistamine levels (Miyamoto et al ., ), HDC activity (Niimi et al ., ), and HNMT activity (Scott et al ., ). The animals (36 male 8‐week‐old C57BL/6J mice and 30 male 8‐week‐old CBA/J mice) were kept in groups of three (100 lux at the cage bottom) for 2 weeks before the experiment.…”

Section: Methodsmentioning

confidence: 99%

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Periodic properties of the histaminergic system of the mouse brain

Rozov

Zant

Karlstedt

et al. 2013

Eur J of Neuroscience

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Brain histamine is involved in the regulation of the sleep-wake cycle and alertness. Despite the widespread use of the mouse as an experimental model, the periodic properties of major markers of the mouse histaminergic system have not been comprehensively characterized. We analysed the daily levels of histamine and its first metabolite, 1-methylhistamine, in different brain structures of C57BL/6J and CBA/J mouse strains, and the mRNA level and activity of histidine decarboxylase and histamine-N-methyltransferase in C57BL/6J mice. In the C57BL/6J strain, histamine release, assessed by in vivo microdialysis, underwent prominent periodic changes. The main period was 24 h peaking during the activity period. Additional 8 h periods were also observed. The release was highly positively correlated with active wakefulness, as shown by electroencephalography. In both mouse strains, tissue histamine levels remained steady for 24 h in all structures except for the hypothalamus of CBA/J mice, where 24-h periodicity was observed. Brain tissue 1-methylhistamine levels in both strains reached their maxima in the periods of activity. The mRNA level of histidine decarboxylase in the tuberomamillary nucleus and the activities of histidine decarboxylase and histamine-N-methyltransferase in the striatum and cortex did not show a 24-h rhythm, whereas in the hypothalamus the activities of both enzymes had a 12-h periodicity. These results show that the activities of histamine-metabolizing enzymes are not under simple direct circadian regulation. The complex and non-uniform temporal patterns of the histaminergic system of the mouse brain suggest that histamine is strongly involved in the maintenance of active wakefulness.

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Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Periodic properties of the histaminergic system of the mouse brain

Rozov

Zant

Karlstedt

et al. 2013

Eur J of Neuroscience

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“…Mice were dosed with compounds between 0900 and 1400 hours and killed by decapitation at 4 h after administration. Brains were quickly frozen in liquid nitrogen, and histamine, t-MH, and other neurotransmitters were measured as reported (43,44).…”

Section: Methodsmentioning

confidence: 99%

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

Yoshimoto

Miyamoto

Shimamura

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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Histamine H3 receptors (H3Rs) are located on the presynaptic membranes and cell soma of histamine neurons, where they negatively regulate the synthesis and release of histamine. In addition, H3Rs are also located on nonhistaminergic neurons, acting as heteroreceptors to regulate the releases of other amines such as dopamine, serotonin, and norepinephrine. The present study investigated the effects of H3R ligands on appetite and body-weight regulation by using WT and H3R-deficient mice (H3RKO), because brain histamine plays a pivotal role in energy homeostasis. The results showed that thioperamide, an H3R inverse agonist, increases, whereas imetit, an H3R agonist, decreases appetite and body weight in diet-induced obese (DiO) WT mice. Moreover, in DiO WT mice, but not in DiO H3RKO mice, imetit reduced fat mass, plasma concentrations of leptin and insulin, and hepatic triglyceride content. The anorexigenic effects of imetit were associated with a reduction in histamine release, but a comparable reduction in histamine release with ␣-fluoromethylhistidine, an inhibitor of histamine synthesis, increased appetite. Moreover, the anorexigenic effects of imetit were independent of the melanocortin system, because imetit comparably reduced appetite in melanocortin 3 and 4 receptor-deficient mice. The results provide roles of H3Rs in energy homeostasis and suggest a therapeutic potential for H3R agonists in the treatment of obesity and diabetes mellitus.autoreceptor ͉ heteroreceptor ͉ appetite regulation O besity has recently become a matter of great concern, because it is considered one of the highest risk factors for diabetes mellitus, hyperlipidemia, and arteriosclerosis. To maintain body weight, caloric intake and energy expenditure must be balanced, and excessive caloric intake is a leading cause of obesity (1). There is growing evidence that the brain receives and integrates information related to energy status from peripheral tissues and that appetite is under the control of numerous neurotransmitters and hormones, such as neuropeptide Y, melanocortin, leptin, and ghrelin (2, 3)Histamine is a classical inflammatory mediator in peripheral tissues and also functions as a neurotransmitter in the brain. Histamine plays a pivotal role in various physiological functions, such as feeding behavior and energy homeostasis (4). Intracerebroventricular administration of histamine consistently decreases appetite in several species (4). Mice with genes disrupted for histamine H1 receptor or histidine decarboxylase (HDC), a ratelimiting enzyme for histamine synthesis, are prone to becoming obese on a high-fat diet or at advanced age (5-8). Furthermore, several antipsychotic drugs with high affinities for H1 receptors are known to cause weight gain in rodents and humans (9). These results suggest a significant role for histamine and H1 receptors in feeding behavior and body-weight regulation.Histamine H3 receptors (H3Rs) were pharmacologically identified more than a decade ago and recently cloned (10, 11). They are predominantly ex...

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“…The substances were separated using a cation exchange column (Eicopak SC-5ODS; Eicom Corp., Kyoto, Japan) equipped with a guard column (Prepaset CA-ODS; Eicom), and measured by the column switching o-phthalaldehyde (OPA) post-column fluorescence derivation method with excitation and fluorescence wavelengths of 335 and 450 nm, respectively (27). The mobile phase, 0.1 mol/L acetate buffer-methanol solution (91 : 9, v/v) containing 220 mg/L sodium 1-octansulfonate, was passed at a flow rate of 0.5 mL/min.…”

Section: Y-maze Spontaneous Alternation Behavior Testmentioning

confidence: 99%

Dried bonito broth improves cognitive function via the histaminergic system in mice

et al. 2014

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Bonito extract, i.e., dried bonito broth (DBB), has been reported to counteract mental fatigue and to increase performance in a simple calculation task, but the mechanism by which DBB increases task performance is not known. The brain neurotransmitter histamine is biosynthesized only from histidine in the tuberomammillary nucleus. Histamine neurons are projected to almost all areas of the cerebral cortex, and histamine has various behavioral and neurobiological functions, particularly in recognition memory. Here we used a mouse model to investigate the effects of the oral ingestion of DBB, which contains abundant histidine, as well as the ingestion of histidine on cognitive function. In a retention trial of novel object recognition test, the administration of 1.6 g/ kg of DBB and 500 mg/kg of histidine significantly increased the animals' exploratory behavior toward a novel object, and that these agents significantly increased the spontaneous alternation behavior ratio in a Y-maze under conditions of scopolamine-induced amnesia, which induced learning and memory impairment. These results suggested the improvement of spatial short-term working memory in a scopolamine amnesia model, as well as the strengthening of visual cognitive function by a single ingestion of DBB and histidine. Interestingly, the administration of αFMH, which is an inhibitor of histamine biosynthesis, eliminated the increase in the spontaneous alternation behavior ratio by DBB ingestion in the scopolamine-induced amnesia model, suggesting that DBB may improve working memory impairment via activation of the histaminergic neuron system. Bonito (skipjack tuna, Katsuwonus pelamis) is known as katsuo in Japan and is very familiar to Japanese people from ancient times. Dried bonito broth (katsuobushi-dashi, DBB), a hot-water extract of dried bonito muscle, is ubiquitous in the Japanese diet, enhancing the taste and flavor of dishes (12,19). DBB has also traditionally been considered a folk remedy for fatigue in the southern part of Japan. In previous works, DBB was confirmed to be effective against fatigue in animal and human studies (22,32). We demonstrated that the daily ingestion of DBB by humans improves mood, especially by alleviating mental fatigue (31), and that it increases performance on a simple calculation task (21). However, the mechanisms underlying the ability of DBB to increase task performance are not yet known. The brain neurotransmitter histamine is synthesized from histidine by tuberomammillary nuclei neurons of the posterior hypothalamus, and histaminergic neurons are projected to almost all areas of the cerebral cortex (34). Histamine is known to be involved in behavioral and neurobiological functions such as sleep-cycle maintenance and adjustment (16,37), eating behavior and energy metabolism (17,26,36), stress response (38,40), and learning and mem-

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Simultaneous fluorometric measurement of histamine and tele-methylhistamine levels in rodent brain by high-performance liquid chromatography

Cited by 18 publications

References 29 publications

Periodic properties of the histaminergic system of the mouse brain

Periodic properties of the histaminergic system of the mouse brain

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

Dried bonito broth improves cognitive function via the histaminergic system in mice

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