Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing

Rodríguez-Pombo, Lucía; Martínez-Castro, Laura; Xu, Xiaoyan; Ong, Jun Jie; Rial, Carlos; García, Daniel Nieto; González-Santos, Alejandro; Flores-González, Julian; Álvarez-Lorenzo, Carmen; Basit, Abdul W.; Goyanes, Álvaro

doi:10.1016/j.ijpx.2023.100166

Cited by 11 publications

(9 citation statements)

References 42 publications

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“…It was crucial to optimise the printing conditions for each unique structure due to the voxelization program's varying intensity of projected light based on shape thickness and geometry (ESI Table 2 well as mechanical properties could be lacking, additionally if overcured the part could completely lose resolution. 6 For example, the highest resolution for the sphere trapped in the pillared structure required 18 seconds of exposure time (under 1 min total time for the whole structure). Among the printed objects, the chess piece demonstrated the highest resolution, with the smallest feature size measuring between 300 and 500 µm (Fig.…”

Section: 4 and Esi Table 1 †) This Difference In Conversion %mentioning

confidence: 99%

Glycerol-based sustainably sourced resin for volumetric printing

Krumins,

Lentz,

Sutcliffe

et al. 2024

Green Chem.

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Section: 4 and Esi Table 1 †) This Difference In Conversion %mentioning

confidence: 99%

Glycerol-based sustainably sourced resin for volumetric printing

Krumins,

Lentz,

Sutcliffe

et al. 2024

Green Chem.

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“…Also, Rodríguez-Pombo et al . loaded polyethylene glycol diacrylate (PEGDA) hydrogels with paracetamol to simultaneously produce several tablets through VAM within seconds, [ 60 ] opening possibilities for personalized tablet manufacturing, although challenges remain to make the photo-crosslinkable hydrogel edible.…”

Section: Materials Used For Vammentioning

confidence: 99%

A review of materials used in tomographic volumetric additive manufacturing

Madrid-Wolff,

Toombs,

Rizzo

et al. 2023

MRS Communications

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Volumetric additive manufacturing is a novel fabrication method allowing rapid, freeform, layer-less 3D printing. Analogous to computer tomography (CT), the method projects dynamic light patterns into a rotating vat of photosensitive resin. These light patterns build up a three-dimensional energy dose within the photosensitive resin, solidifying the volume of the desired object within seconds. Departing from established sequential fabrication methods like stereolithography or digital light printing, volumetric additive manufacturing offers new opportunities for the materials that can be used for printing. These include viscous acrylates and elastomers, epoxies (and orthogonal epoxy-acrylate formulations with spatially controlled stiffness) formulations, tunable stiffness thiol-enes and shape memory foams, polymer derived ceramics, silica-nanocomposite based glass, and gelatin-based hydrogels for cell-laden biofabrication. Here we review these materials, highlight the challenges to adapt them to volumetric additive manufacturing, and discuss the perspectives they present. Graphical abstract

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“…As such, volumetric printing does not employ a layer-by-layer process:, instead, the structure is directly printed in three-dimensions in a layerless fashion, foregoing the need for support structures commonly seen in other layer-by-layer technologies [12]. The utilisation of volumetric printing in pharmaceutics has been explored, with drug loaded torus printlets able to be printed in seconds [13], and the ability to simultaneously print multiple drug-loaded printlets [14] for even faster fabrication.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of 3D Printed Mutable Drug Delivery Devices: A Comparative Study of Volumetric and Digital Light Processing printing

Oh,

Ong,

Alfassam

et al. 2024

Preprint

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Mutable devices and dosage forms have the capacity to dynamically transform dimensionally, morphologically and mechanically upon exposure to non-mechanical external triggers. By leveraging these controllable transformations, these systems can be used as minimally invasive alternatives to implants and residence devices, foregoing the need for complex surgeries or endoscopies. 4D printing, the fabrication of 3D-printed structures that evolve their shape, properties, or functionality in response to stimuli over time, allows the production of such devices. This study explores the potential of volumetric printing, a novel vat photopolymerisation technology capable of ultra-rapid printing speeds, by comparing its performance against established digital light processing (DLP) printing in fabricating hydrogel-based drug-eluting devices. Six hydrogel formulations consisting of 2-(acryloyloxy)ethyl]trimethylammonium chloride solution, lithium phenyl-2,4,6-trimethylbenzoylphosphinate, varying molecular weights of the crosslinking monomer, poly(ethylene glycol) diacrylate, and paracetamol as a model drug were prepared for both vat photopolymerisation technologies. Comprehensive studies were conducted to investigate the swelling and water sorption profiles, drug release kinetics, and physicochemical properties of each formulation. Expandable drug-eluting 4D devices were successfully fabricated within 7.5 s using volumetric printing and were shown to display equivalent drug release kinetics to prints created using DLP printing, demonstrating drug release, swelling, and water sorption properties equivalent to or better than those of DLP-printed devices. The reported findings shed light on the advantages and limitations of each technology for creating these dynamic drug delivery systems and provides a direct comparison between the two technologies, while highlighting the promising potential of volumetric printing and further expanding the growing repertoire of pharmaceutical printing.

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Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing

Cited by 11 publications

References 42 publications

Glycerol-based sustainably sourced resin for volumetric printing

Glycerol-based sustainably sourced resin for volumetric printing

A review of materials used in tomographic volumetric additive manufacturing

Fabrication of 3D Printed Mutable Drug Delivery Devices: A Comparative Study of Volumetric and Digital Light Processing printing

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