Simultaneous expression of th1 cytokines and IL-4 confers severe characteristics to type I autoimmune hepatitis in children

Cherñavsky, Alejandra Claudia; Paladino, Natalia; Rubio, Andrea; Biasio, María Bárbara De; Períolo, Natalia; Cuarterolo, Miriam; Goñi, Javier; Galoppo, Cristina; Cañero-Velasco, María Cristina; Muñoz, Alberto; Fainboim, Hugo; Fainboim, Leonardo

doi:10.1016/j.humimm.2004.03.004

Cited by 38 publications

(36 citation statements)

References 50 publications

(60 reference statements)

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“…[79] Limited data are available for the participation of cytokines in the development of AIH. In a previous study, Chernavsky et al [80] analyzed the expression of cytokines in liver biopsies from pediatric autoimmune hepatitis (PAIH) patients in comparison with liver control samples obtained from cadaveric liver donors. While the expression of IFN-γ and IL-12p40 was not detectable in control livers, it was clearly unregulated, [80] and showed an increased expression of IL-18, IL-4 and the 1L-12 β2 chain receptor in PAIH patients.…”

Section: Structural Organization Of the Liver And Cytokines Potentialmentioning

confidence: 99%

“…In a previous study, Chernavsky et al [80] analyzed the expression of cytokines in liver biopsies from pediatric autoimmune hepatitis (PAIH) patients in comparison with liver control samples obtained from cadaveric liver donors. While the expression of IFN-γ and IL-12p40 was not detectable in control livers, it was clearly unregulated, [80] and showed an increased expression of IL-18, IL-4 and the 1L-12 β2 chain receptor in PAIH patients. The unexpected increase of mRNA for IL-4, a typical Th2 cytokine, was found in conjunction with a severe histological inflammation in AIH.…”

Section: Structural Organization Of the Liver And Cytokines Potentialmentioning

confidence: 99%

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Physiological potential of cytokines and liver damages

Mannaa¹,

Abdel-Wahhab²

2016

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Cytokines are soluble extracellular small molecular weight protein or peptide. They are produced by virtually every nucleated cell type in response to injurious stimuli to control body metabolism, infection, inflammation and tissue or neuronal damage; therefore acting as messengers between tissues and the immune system; and participating in many physiological processes through their either anti-inflammatory or pro-inflammatory characteristics. Many cytokines have multiple cellular sources and targets, as well as many natural inducers and inhibitors. In pathophysiological conditions and during the early phase of chronic liver diseases, agent like virus, bacteria, parasites, ethanol, or toxins, induce secretion of cytokines at high levels. The presence of cytokine antagonists and soluble cytokine receptors, often released in concert with their respective cytokine agonist, presents additional complexity to interpretation.

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Section: Structural Organization Of the Liver And Cytokines Potentialmentioning

confidence: 99%

Section: Structural Organization Of the Liver And Cytokines Potentialmentioning

confidence: 99%

Physiological potential of cytokines and liver damages

Mannaa¹,

Abdel-Wahhab²

2016

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“…In recent years, a growing body of evidence has demonstrated that NKT cells are prime targets for immunomodulation due to their ability to secrete high levels of cytokines, including IFN-␥ and IL-4, within minutes of activation (25,26). Interestingly, clinical and experimental studies have associated IL-4 produced by activated hepatic NKT cells with a more aggressive hepatic injury in children with AIH and in experimental AIH (27,28).…”

Section: Autoimmune Hepatitismentioning

confidence: 99%

CCR5 in T Cell-Mediated Liver Diseases: What’s Going On?

Ajuebor

Carey

Swain

2006

The Journal of Immunology

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The chemokine receptor CCR5 came into worldwide prominence a decade ago when it was identified as one of the major coreceptors for HIV infectivity. However, subsequent studies suggested an important modulatory role for CCR5 in the inflammatory response. Specifically, CCR5 has been reported to directly regulate T cell function in autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. Moreover, T cell-mediated immune responses are proposed to be critical in the pathogenesis of autoimmune and viral liver diseases, and recent clinical and experimental studies have also implicated CCR5 in the pathogenesis of autoimmune and viral liver diseases. Therefore, in this brief review, we highlight the evidence that supports an important role of CCR5 in the pathophysiology of T cell-mediated liver diseases with specific emphasis on autoimmune and viral liver diseases.

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“…In AIH patients, serum levels of tumor necrosis factor-a and interleukin-6 have been reported to be associated with the disease activity [13,14]. Furthermore, increased expressions of interleukin-4 and interferon-c are shown in the liver specimens of AIH patients [15]. Thus, UDCA may control the disease activity of AIH on the basis of these mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis

et al. 2009

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Purpose This study aimed to investigate the efficacy of ursodeoxycholic acid (UDCA) for Japanese patients with autoimmune hepatitis (AIH). Methods One hundred forty-seven patients were investigated. Results As initial treatment, 25 patients received UDCA (300-600 mg/day) monotherapy (UDCA group), 40 received a combination of prednisolone (PSL) (C20 mg/ day) and UDCA (combination group), 68 received PSL monotherapy (PSL group), and 14 received other treatments. During the follow-up, in the UDCA group, PSL was added to 8 of 12 patients failing to achieve the normalization of serum transaminase levels with UDCA monotherapy. Cumulative incidence of the normalization of serum transaminase levels was 64% in the UDCA group, 95% in the combination group, and 94% in the PSL group (log-rank test, P = 0.0001). UDCA group required longest periods until the normalization of serum transaminase levels. Eleven patients, who achieved persistent normalization Y. Miyake (&) Á F. Ikeda Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan e-mail: miyakeyasuhiro@hotmail.com F. Ikeda e-mail: fikeda@md.okayama-u.ac.jp -009-9155-9 of serum transaminase levels with UDCA monotherapy, did not reach liver failure or develop hepatocellular carcinoma for 49.7 (range = 13.4-137.3) months. Meanwhile, during the taper of PSL, doses of PSL at the initial relapse were lower in patients treated with PSL and UDCA than in those treated with PSL monotherapy, and initial relapse occurred earlier in patients treated with PSL monotherapy. Conclusions UDCA monotherapy is effective for some Japanese AIH patients; however, UDCA monotherapy for patients with either high-grade inflammatory activity or poor residual capacity of liver function is not recommended because they may reach liver failure before achievement of remission. Meanwhile, additional use of UDCA during the taper of corticosteroids may be effective for the prevention of early relapse.123 Hepatol Int (2009) 3:556-562 DOI 10.1007/s12072

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Simultaneous expression of th1 cytokines and IL-4 confers severe characteristics to type I autoimmune hepatitis in children

Cited by 38 publications

References 50 publications

Physiological potential of cytokines and liver damages

Physiological potential of cytokines and liver damages

CCR5 in T Cell-Mediated Liver Diseases: What’s Going On?

Efficacy of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis

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