Simultaneous Evaluation of Epithelial Cell Function by CA 125 and Stromal Cell Activity by Aminoterminal Propeptide of Type III Procollagen (PIIINP) in Ovarian Carcinoma

Tomás, Cǎndido; Penttinen, Jorma; Risteli, Juha; Risteli, Leila; Kauppila, Antti

doi:10.3109/07853899009147253

Cited by 16 publications

(4 citation statements)

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“…In patients with benign cystadenomas of the ovary, the PIIINP concentrations do not differ from those in age-matched control persons (13). In a prospective study we found a negative correlation between the initial PIIINP concentration and survival time (p = 0.01) in patients who died during the follow-up period of 1-19 months (15) . No such relationship was found between CA 125 and survival time .…”

Section: Biochemical Basis For the Piiinp Measurementmentioning

confidence: 64%

“…We have studied the concentration of PIIINP in serum in several series of patients with ovarian carcinom a. both retrospectively and prospectively (13)(14)(15). Elevated values are quite common , occurring in about 80% of the patients with advanced disease before chemotherapy (Fig.…”

Section: Biochemical Basis For the Piiinp Measurementmentioning

confidence: 99%

“…During cytotoxic chemotherapy. we compared the changes in serum PIIINP with the clinical responses (complete or partial response, stable or progressive disease, the total number of periods analysed being 66) in a prospective study of 50 patients (15) . In general, there was a good correlation between the clinical course of the carcinoma and the behaviour of both CA 125 and PIIINP.…”

Section: Biochemical Basis For the Piiinp Measurementmentioning

confidence: 99%

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Aminoterminal propeptide of type III procollagen in ovarian cancer

Risteli

Puistola

et al. 1992

Acta Obstet Gynecol Scand

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Acta Obstet Gynecol Scand 1992; 71 Suppl 155: 99-103 The concentration of the aminoterrninal propeptide of type III procollagen (PIIINP) in serum is a measure of the activity of the metabolism of type III collagen, which is a major constituent of soft connective tissues and of the connective tissue stroma of solid tumours. In advanced ovarian carcinoma, serum PIIINP serves as a tumour-associated antigen. its changes reflecting and preceding changes in the clinical behaviour of the malignancy. Elevated values of serum PIIINP are also observed in endometrial and cervical malignancies, though less frequently than in ovarian tumours. Very high concentrations of PIIINP are found in ovarian carcinoma ascites. suggesting an ongoing fibroproliferative reaction in the peritoneal cavity as a response to the tumour.

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Section: Biochemical Basis For the Piiinp Measurementmentioning

confidence: 64%

Section: Biochemical Basis For the Piiinp Measurementmentioning

confidence: 99%

Section: Biochemical Basis For the Piiinp Measurementmentioning

confidence: 99%

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Aminoterminal propeptide of type III procollagen in ovarian cancer

Risteli

Puistola

et al. 1992

Acta Obstet Gynecol Scand

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“…One of them contracted recurrent cancer 8 months after operation. Six patients responded to cytotoxic chemotherapy by stabilization of the disease, which was transient in two cases (progression at 7 and 8 months) and which still continues in four patients at the end of the follow-up (16,18,19, and 40 months). In 12 patients, the malignancy progressed continuously.…”

Section: Methodsmentioning

confidence: 96%

Serum concentrations of CA 125 and aminoterminal propeptide of type III procollagen (PIIINP) in patients with endometrial carcinoma

Tomás

Penttinen

Risteli

et al. 1990

Cancer

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Serum CA 125 (a marker of coelomic epithelial cells) and aminoterminal propeptide of type III procollagen (PIIINP; an indicator of collagen metabolism) concentrations were measured in 148 patients with endometrial carcinoma. An initial serum concentration of CA 125 was pathologic in 17% of the patients, the frequency of abnormal values being higher (P = 0.0001) in advanced (63%) than in early disease (10%). The serum PIIINP concentration was increased in 35% of the patients and more often (P less than 0.05) so in advanced (63%) than in early disease (31%). Among all the patients, at least one of the tumor markers was increased in 43% of the cases. In early disease 12 of 108 patients contracted recurrent cancer. The accuracy of the pathologic CA 125 (9%) and PIIINP (18%) concentrations in their prediction was poor. In the total material, pathologic CA 125 and PIIINP concentrations appeared simultaneously in 11 patients, of whom eight had poor prognoses. In monitoring of treatment response of 24 patients, regression was accompanied by normal or decreasing CA 125 and PIIINP values. The persistence of pathologic CA 125 and/or PIIINP concentration predicted relapse of the malignancy. In progressive disease, CA 125 and PIIINP concentrations together or separately remained at a pathologic level or increased continuously. In clinically stable endometrial carcinoma, CA 125 gave false-negative results in 71% of the determinations and PIIINP only in 12%. The current results suggest the use of CA 125 and PIIINP, simultaneously, in monitoring the clinical course of advanced endometrial carcinoma.

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Coagulation-fibrinolysis system and markers of collagen metabolism in lung cancer

Gabazza

Taguchi

Yamakami

et al. 1992

Cancer

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Background. Evidence suggests that the fibrinolysis system and peritumoral connective tissue play important roles in tumor spread. Methods. In this study, the authors evaluated the following parameters in 30 consecutive patients with lung cancer: thrombin‐antithrombin complex (TAT), cross‐linked fibrin split products D‐dimer (DD), plasmin‐alpha2‐antiplasmin inhibitor complex (PAP), and two antigens related to connective tissue, the aminoterminal propeptide of type III procollagen (PIIIP) and the 7s domain of type IV collagen (7s‐collagen). Results. Each parameter was increased significantly in the patients with cancer compared with the control subjects. Except for PIIIP, their concentration in blood was elevated to Significantly greater extent in the patients with distant metastases. The PAP concentration correlated well with the plasma concentration of TAT (r = 0.5; P < 0.01) and DD (r = 0.9; P < 0.0001). There was also strong correlation between the serum concentrations of PIIIP and 7s‐collagen (r = 0.7; P < 0.001). In patients with localized disease, DD levels were correlated significantly with those of PIIIP (Spearman rank‐order correlation [ra] = 0.6; P < 0.025) and 7s‐collagen (ra = 0.6; P < 0.01). In the group with disseminated metastases, there was significant inverse relationship between serum PAP concentrations and serum concentrations of 7s‐collagen (ra = −0.6; P < 0.025). Conclusions. These results confirm the presence of subclinical chronic activation of the parameters of intravascular clotting‐fibrinolysis and alterations in the extracellular matrix of patients with lung cancer. These parameters may be useful as indicators of the clinical progression of malignant disease, particularly of lung cancer.

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Simultaneous Evaluation of Epithelial Cell Function by CA 125 and Stromal Cell Activity by Aminoterminal Propeptide of Type III Procollagen (PIIINP) in Ovarian Carcinoma

Cited by 16 publications

References 10 publications

Aminoterminal propeptide of type III procollagen in ovarian cancer

Aminoterminal propeptide of type III procollagen in ovarian cancer

Serum concentrations of CA 125 and aminoterminal propeptide of type III procollagen (PIIINP) in patients with endometrial carcinoma

Coagulation-fibrinolysis system and markers of collagen metabolism in lung cancer

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