Simultaneous estimation of shear elastic modulus and backscatter coefficient: Phantom and in human liver in vivo study

Rouyer, Julien; Torres, Gabriela; Amador, Carolina; Urban, Matthew W.; Lavarello, Roberto

doi:10.1109/ultsym.2016.7728874

Cited by 2 publications

(2 citation statements)

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“…The Verasonics research ultrasound system is an open-platform ultrasound system that gives its users control over the transmit waveform, access to the pre-beamformed data, and control over intermediate processing steps that are typically hidden in clinical imaging systems. It has been widely used as a test-bed for novel beamforming applications, a pedagogic tool for teaching ultrasound imaging physics, and for other research applications (Kaczkowski et al 2011, Rouyer et al 2016, Deng et al 2017, Khairalseed et al 2019.…”

Section: Data Acquisition With the Verasonics Imaging Systemmentioning

confidence: 99%

“…The first challenge is determining system-specific settings necessary for QUS, as the multiscale-imaging platform uses a Verasonics research system with high-frequency transducers (18.5 and 28.5 MHz) that, to our knowledge, have not been used for QUS in the literature. Other groups have published RPM-based QUS using the Verasonics system on low-frequency transducers (2 MHz) (Rouyer et al 2016), but the high-frequency transducers require a non-standard Verasonics acquisition mode and related parameters (Kaczkowski 2016). The high-frequency transducers were used because they provide spatial resolution in the mesoscale (2-100 µm) and high-macroscale (> 100 µm), making them a good basis for initial comparisons to the high resolution SHG.…”

Section: Introductionmentioning

confidence: 99%

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Challenges of conducting quantitative ultrasound with a multimodal optical imaging system

Pinkert¹,

Hall²,

Eliceiri³

2021

Phys. Med. Biol.

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High-frequency quantitative ultrasound is a potential non-invasive source of imaging cell-tissue scale biomarkers for major diseases such as heart disease, cancer, and preterm birth. However, one of the barriers to developing such biomarkers is that it is labor-intensive to compare quantitative ultrasound images to optical images of the tissue structure. We have previously developed a multiscale imaging system that can obtain registered qualitative ultrasound and optical images, but there are further technical challenges to obtaining quantitative data: System-specific details of obtaining and processing data with Verasonics high-frequency transducers; the need for high-frequency reference phantoms; and off-axis clutter from imaging above a glass coverslip. This paper provides a characterization of the Verasonics ultrasound system with the 18.5 MHz L22-14v and 28.5 MHz L38-22v transducers, describes the construction of high-frequency reference phantoms, and details methods for reducing off-axis clutter. The paper features a demonstration multiscale image of a wild type mouse mammary gland that incorporates quantitative ultrasound with both transducers and second harmonic generation microscopy. These advances demonstrate a way to obtain, on a single system with a cohesive and integrated pipeline, quantitative ultrasound data that is correlated with optical imaging without the need for extensive sample preparation.

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Section: Data Acquisition With the Verasonics Imaging Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%