Simultaneous Estimation of Fimasartan potassium trihydrate and Atorvastatin calcium with Greenness Assessment using HPLC and UV Spectrophotometric Methods

Akabari, Ashok; Mistry, Pooja; Patel, Sarika; Surati, Jasmina; Patel, Sagar P.; Shah, Umang

doi:10.1016/j.greeac.2023.100067

Cited by 12 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, there are several methods available to assess the environmental sustainability of an analytical technique. These methodologies include eco-scale assessment, the analytical greenness metric approach (AGREE), the Green Analytical Procedure Index (GAPI), and the national environmental method index (NEMI) [29][30][31][32]. These tools offer the capability to effectively assess the eco-friendliness attributes of a given analytical procedure.…”

Section: Introductionmentioning

confidence: 99%

“…The assessment takes into account factors such as solvent consumption, waste generation, and energy usage during the analytical process. It will evaluate the ecological footprint of the developed methods, allowing us to quantify their environmental impact in comparison to conventional analytical techniques [29]. The incorporation of "green" practices in analytical methods aligns with the growing global emphasis on sustainable development and environmentally responsible research [30].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stability-Indicating TLC-Densitometric and HPLC Methods for Simultaneous Determination of Teneligliptin and Pioglitazone in Pharmaceutical Dosage Forms with Eco-Friendly Assessment

Akabari,

Gajiwala,

Patel

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

The combination of multiple drugs in pharmaceutical formulations has greatly improved the management of complex medical conditions, particularly benefiting patients with type 2 diabetes mellitus. Two powerful antidiabetic agents, teneligliptin hydrobromide hydrate (TEN) and pioglitazone hydrochloride (PIO), play key roles in regulating blood glucose levels. In this study, we introduce innovative methods for the simultaneous quantification of TEN and PIO in pharmaceutical formulations, ensuring accuracy and stability assessment. Our TLC-densitometric approach employs a mobile phase consisting of Methanol, Toluene, Ethyl Acetate, and Triethylamine (1:7:2:0.1, v/v/v/v) on TLC silica gel plates, followed by densitometric scanning at 268 nm. Meanwhile, the RP-HPLC method utilizes an isocratic elution with acetonitrile and acetate buffer (pH 2.3, 60:40 v/v) on a C18 column, delivering diode-array detection at 235 nm. Both methods offer exceptional accuracy and reliability, serving as valuable tools for pharmaceutical quality control. Furthermore, our research incorporates an environmental impact assessment to align with global sustainability goals. We consider factors such as solvent consumption, waste generation, and energy usage, using assessment tools like the eco-scale assessment, AGREE, Green Analytical Procedure Index (GAPI), and the national environmental method index (NEMI) to gauge the environmental impact of our methods. By adopting these techniques, pharmaceutical companies can enhance their drug quality control processes and fulfill their environmental responsibilities. Comprehensive statistical comparisons, including t-tests and F-tests, validate the outcomes of the TLC-densitometric and RP-HPLC methods, ensuring their effectiveness in drug formulation analysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stability-Indicating TLC-Densitometric and HPLC Methods for Simultaneous Determination of Teneligliptin and Pioglitazone in Pharmaceutical Dosage Forms with Eco-Friendly Assessment

Akabari,

Gajiwala,

Patel

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

A sustainable RP‐HPLC method for concurrent estimation of capecitabine and celecoxib in liposomal formulation: Greenness and whiteness appraisal

Shewale,

Gomte,

Jain

2024

Archiv der Pharmazie

View full text Add to dashboard Cite

Liposomes have been reported for combination therapy due to their ability to carry both hydrophilic and lipophilic drugs together. The current investigation aims to develop a novel, eco‐friendly, and sustainable reverse‐phase high‐performance liquid chromatography (RP‐HPLC) method for the simultaneous quantification of capecitabine and celecoxib co‐encapsulated in liposomes. The method reported herein uses a C18 column (4.6 × 250 mm2, 5 μm) and a mobile phase consisting of water, and acetonitrile/methanol in a ratio of 60:40, containing 0.1% formic acid in both the phases. The flow rate is maintained at 1 mL/min, with an injection volume of 10 μL in the gradient mode. Detection is set at λmax = 240 nm for capecitabine and 252 nm for celecoxib. The developed liposomes are mono‐disperse with a surface potential of −6.93 mV. The average size of the liposomes is 142 nm. The percentage entrapment efficiency for capecitabine is 52.39 ± 0.94%, and for celecoxib, it is 77.13 ± 0.74%. The Analytical Greenness Metric of 0.61 and Analytical Eco‐Scale Score of 75 signify the greenness of the developed method. Also, the Red‐Green‐Blue model shows excellent whiteness, with a score of 83.2. Thus, the developed method offers a reliable, accurate, precise, buffer‐free, and environment‐friendly RP‐HPLC approach for the simultaneous analysis of capecitabine and celecoxib co‐encapsulated in liposomes.

show abstract

A Dual-Mode Spectrophotometric and Fluorescent Probe Based on Lignin-Derived Carbon Dots for the Detection of Atorvastatin Calcium in a Bulk Powder and a Commercial Product

Aldakhil,

Alarfaj,

Al-Tamimi

et al. 2024

J Fluoresc

View full text Add to dashboard Cite

Simultaneous Estimation of Fimasartan potassium trihydrate and Atorvastatin calcium with Greenness Assessment using HPLC and UV Spectrophotometric Methods

Cited by 12 publications

References 25 publications

Stability-Indicating TLC-Densitometric and HPLC Methods for Simultaneous Determination of Teneligliptin and Pioglitazone in Pharmaceutical Dosage Forms with Eco-Friendly Assessment

Stability-Indicating TLC-Densitometric and HPLC Methods for Simultaneous Determination of Teneligliptin and Pioglitazone in Pharmaceutical Dosage Forms with Eco-Friendly Assessment

A sustainable RP‐HPLC method for concurrent estimation of capecitabine and celecoxib in liposomal formulation: Greenness and whiteness appraisal

A Dual-Mode Spectrophotometric and Fluorescent Probe Based on Lignin-Derived Carbon Dots for the Detection of Atorvastatin Calcium in a Bulk Powder and a Commercial Product

Contact Info

Product

Resources

About