Abstract:Background: Quantification of cerebral glucose metabolism by dynamic [ 18 F]FDG PET is often limited to the cerebral metabolic rate of glucose (CMRGlu) due to the challenges associated with obtaining microparameters at the voxelwise level (e.g., noise, choice of parameter estimation method, and input function quality). Efforts to avoid invasive arterial sampling include the simultaneous estimation (SIME) approach, which models the image-derived input function (IDIF) by series of exponentials with coefficients … Show more
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