Simultaneous epidural functional near-infrared spectroscopy and cortical electrophysiology as a tool for studying local neurovascular coupling in primates

Zaidi, Ali Danish; Munk, Matthias H. J.; Schmidt, Andreas; Risueno-Segovia, Cristina; Bernard, R; Fetz, Eberhard E.; Logothetis, Nikos K.; Birbaumer, Niels; Sitaram, Ranganatha

doi:10.1016/j.neuroimage.2015.07.019

Cited by 16 publications

(15 citation statements)

References 14 publications

(12 reference statements)

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Section: Applications Of Fnirs To Model Animalsmentioning

confidence: 99%

“…fNIRS studies on non-human primates have focused on customizing and cross-validating this technique with other well-established methods, such as electrophysiological recordings ( Zaidi et al, 2015 ). Previous studies have found a strong correlation between visual stimulus-elicited responses in the primary visual cortex and PFC of monkeys when measured by fNIRS and via electrodes in the same experiment ( Wakita et al, 2010 ; Zaidi et al, 2015 ). Interestingly, one study has shown that the activity of the frontal region of monkeys increases in response to various visual stimuli and that the magnitude of the response varies depending on the type of visual stimuli, such as a flower, monkey, snake, or food ( Lee et al, 2017 ).…”

Section: Applications Of Fnirs To Model Animalsmentioning

confidence: 99%

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Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models

Kim

Seo

Jeon

et al. 2017

Molecules and Cells

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Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical imaging technique that indirectly assesses neuronal activity by measuring changes in oxygenated and deoxygenated hemoglobin in tissues using near-infrared light. fNIRS has been used not only to investigate cortical activity in healthy human subjects and animals but also to reveal abnormalities in brain function in patients suffering from neurological and psychiatric disorders and in animals that exhibit disease conditions. Because of its safety, quietness, resistance to motion artifacts, and portability, fNIRS has become a tool to complement conventional imaging techniques in measuring hemodynamic responses while a subject performs diverse cognitive and behavioral tasks in test settings that are more ecologically relevant and involve social interaction. In this review, we introduce the basic principles of fNIRS and discuss the application of this technique in human and animal studies.

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Section: Applications Of Fnirs To Model Animalsmentioning

confidence: 99%

Section: Applications Of Fnirs To Model Animalsmentioning

confidence: 99%

Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models

Kim

Seo

Jeon

et al. 2017

Molecules and Cells

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“…Recent studies also show the potential use of fNIRS for animal models. Zaidi et al [83] measured hemodynamic activity from the primary visual cortex in anesthetized monkeys during visual stimulation. They found a robust and reliable response to the stimulation.…”

Section: Current Clinical Applications Of Fnirsmentioning

confidence: 99%

“…They found that the biofeedback had effects on the regional gray matter variation, psychological test scores and salivary cortisol levels were associated with daily hassles. A compact wearable system consisting of fNIRS, electrocardiography (ECG) and acceleration sensors was developed for 24 h ambulatory monitoring of cerebral hemodynamics, systemic hemodynamics, ECG and actigraphy [83]. Piper et al [19] and Pinti et al [102] developed a wearable Appl.…”

Section: Towards Wearable Brain Monitoring Using Fnirsmentioning

confidence: 99%

Optics Based Label-Free Techniques and Applications in Brain Monitoring

et al. 2020

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Functional near-infrared spectroscopy (fNIRS) has been utilized already around three decades for monitoring the brain, in particular, oxygenation changes in the cerebral cortex. In addition, other optical techniques are currently developed for in vivo imaging and in the near future can be potentially used more in human brain research. This paper reviews the most common label-free optical technologies exploited in brain monitoring and their current and potential clinical applications. Label-free tissue monitoring techniques do not require the addition of dyes or molecular contrast agents. The following optical techniques are considered: fNIRS, diffuse correlations spectroscopy (DCS), photoacoustic imaging (PAI) and optical coherence tomography (OCT). Furthermore, wearable optical brain monitoring with the most common applications is discussed.

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“…FNIRS uses a light emitter-detector pair (optode pair) to measure changes in the concentration of oxygenated ([HbO]) and deoxygenated ([HbR]) hemoglobin in a small volume of tissue (Ferrari and Quaresima, 2012; Villringer, 1997). We have recently demonstrated that fNIRS has high SNR when acquired epidurally (Zaidi et al, 2015), making it ideal for studying local neuro-vascular interactions. Using this technique, we recorded sessions of both spontaneous and stimulus-induced activity in the primary visual cortex of two anesthetized monkeys, where a high-contrast whole-field rotating chequerboard was used as visual stimulus.…”

Section: Introductionmentioning

confidence: 99%

The timing of hemodynamic changes reliably reflects spiking activity

Zaidi

Birbaumer

Fetz

et al. 2018

Preprint

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12Functional neuroimaging is a powerful non-invasive tool for studying brain function, using changes in blood-13 oxygenation as a proxy for underlying neuronal activity. The neuroimaging signal correlates with both spiking, and 14 various bands of the local field potential (LFP), making the inability to discriminate between them a serious 15 limitation for interpreting hemodynamic changes. Here, we record activity from the striate cortex in two 16 anesthetized monkeys (Macaca mulatta), using simultaneous functional near-infrared spectroscopy (fNIRS) and 17 intra-cortical electrophysiology. We find that low-frequency LFPs correlate with hemodynamic signal's peak-18 amplitude, whereas spiking correlates with its peak-time and initial-dip. We also find spiking to be more spatially 19 localized than low-frequency LFPs. Our results suggest that differences in spread of spiking and low-frequency LFPs 20 across cortical surface influence different parameters of the hemodynamic response. Together, these results 21 demonstrate that the hemodynamic response-amplitude is a poor correlate of spiking activity. Instead, we 22 demonstrate that the timing of the initial-dip and the hemodynamic response are much more reliable correlates of 23 spiking, reflecting bursts in spike-rate and total spike-counts respectively. 24

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Simultaneous epidural functional near-infrared spectroscopy and cortical electrophysiology as a tool for studying local neurovascular coupling in primates

Cited by 16 publications

References 14 publications

Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models

Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models

Optics Based Label-Free Techniques and Applications in Brain Monitoring

The timing of hemodynamic changes reliably reflects spiking activity

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