Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column

Naghdi, Elahe; Fakhari, Ali Reza; Bača, Martin; Malsche, Wim De

doi:10.1016/j.chroma.2019.460752

Cited by 13 publications

(7 citation statements)

References 39 publications

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“…Enantioseparation of several non-steroidal anti-inflammatory drugs (ketoprofen, ketorolac, indoprofen, fenoprofen, suprofen, ibuprofen, and flurbiprofen) was performed using a dynamically coated pillar array column with hydroxypropyl-β-CD as a CS with improved enantioresolution [ 15 ]. Several works published the use of β-CD derivatives in counter current chromatography.…”

Section: Cyclodextrin-based Stationary Phasesmentioning

confidence: 99%

An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)

Grybinik

Bosáková

2021

Monatsh Chem

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Graphic abstract This review provides a brief survey of chiral separation of pharmaceutically active substances published over the last 3 years (2018–2020). Chiral separation of drugs is an important area of research. The control of enantiomeric purity and determination of individual enantiomeric drug molecules is a necessity especially for clinical, analytical, and regulatory purposes. Among chromatographic resolution methods, high-performance liquid chromatography based on chiral stationary phases remains the most popular and effective method used for chiral separation of various drugs. In this review, attention is paid to several classes of chiral stationary phases that have been the most frequently used for drug enantioseparation during this period.

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Section: Cyclodextrin-based Stationary Phasesmentioning

confidence: 99%

An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)

Grybinik

Bosáková

2021

Monatsh Chem

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“…The concentration of the CSP in the solution determines the thickness of the stationary phase film [ 41 ]. Dynamic coating allows the replacement of the selector being one of the benefits for this technique [ 42 ].…”

Section: Coating Methodsmentioning

confidence: 99%

“…Another example of a dynamic coating procedure was described by Naghdi et al [ 42 ], specifically, of coating hydroxypropyl-β-cyclodextrin onto porous silica. The new CSP was prepared in a pillar array column, a feasible alternative to packed bed columns and monoliths since they allowed a homogeneous flow direction and a reduced back pressure.…”

Section: Coating Methodsmentioning

confidence: 99%

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Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods

et al. 2021

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Enantioselective chromatography is one of the most used techniques for the separation and purification of enantiomers. The most important issue for a specific successful enantioseparation is the selection of the suitable chiral stationary phase (CSP). Different synthetic approaches have been applied for the preparation of CSPs, which embrace coating and immobilization methods. In addition to the classical and broadly applied coating and immobilization procedures, innovating strategies have been introduced recently. In this review, an overview of different methods for the preparation of coated and immobilized CSPs is described. Updated examples of CSPs associated with the various strategies are presented. Considering that after the preparation of a CSP its characterization is fundamental, the methods used for the characterization of all the described CSPs are emphasized.

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“…A chiral liquid chromatography column, prepared by coating hydroxypropyl-β-cyclodextrin onto a reversed-phase porous silicon pillar array column, was developed by Naghdi et al [ 81 ]. The ES efficiency of the developed column was evaluated with mixtures of non-steroidal anti-inflammatory drugs as the analytes, under nano-LC conditions.…”

Section: β-Cyclodextrin-based Cspsmentioning

confidence: 99%

Polysaccharide- and β-Cyclodextrin-Based Chiral Selectors for Enantiomer Resolution: Recent Developments and Applications

Bui

Rosenau

2021

Molecules

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Polysaccharides, oligosaccharides, and their derivatives, particularly of amylose, cellulose, chitosan, and β-cyclodextrin, are well-known chiral selectors (CSs) of chiral stationary phases (CSPs) in chromatography, because they can separate a wide range of enantiomers. Typically, such CSPs are prepared by physically coating, or chemically immobilizing the polysaccharide and β-cyclodextrin derivatives onto inert silica gel carriers as chromatographic support. Over the past few years, new chiral selectors have been introduced, and progressive methods to prepare CSPs have been exploited. Also, chiral recognition mechanisms, which play a crucial role in the investigation of chiral separations, have been better elucidated. Further insights into the broad functional performance of commercially available chiral column materials and/or the respective newly developed chiral phase materials on enantiomeric separation (ES) have been gained. This review summarizes the recent developments in CSs, CSP preparation, chiral recognition mechanisms, and enantiomeric separation methods, based on polysaccharides and β-cyclodextrins as CSs, with a focus on the years 2019–2020 of this rapidly developing field.

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Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column

Cited by 13 publications

References 39 publications

An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)

An overview of chiral separations of pharmaceutically active substances by HPLC (2018–2020)

Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods

Polysaccharide- and β-Cyclodextrin-Based Chiral Selectors for Enantiomer Resolution: Recent Developments and Applications

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