Simultaneous dual‐nuclei imaging for motion corrected detection and quantification of ¹⁹F imaging agents

Abstract

Fluorine MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Because non-proton MRI applications lack morphological information, accompanying proton images are needed to elucidate the spatial tissue context. Furthermore, low concentrations typical of targeted molecular imaging agents require long examinations for signal averaging during which physiological motion may lead to blurring, underestimation in signal quantification, and erroneous localization of the agent distribution. Novel methods for truly simultaneous acquisition of dual-nuclei MR data are presented that offer efficient and precise anatomical localization of fluorine signals using accurate motion correction based on contemporaneous proton signals. The feasibility of simultaneous dual-nuclei MRI motion correction and corresponding dual-resolution reconstruction, providing nuclei-specific spatial resolution to retrospectively optimize the balance between signal-to-noise ratio and resolution, is shown on a clinical 3 T MR system. Magn Reson Med 66:1116-1122,

Angiogenesis and airway reactivity in asthmatic Brown Norway rats

“…Simultaneous 3D 19 F/ 1 H imaging was used employing a novel steady state ultrashort echo time technique (TE/TR=0.1ms/1.96ms) with the frequencies set to the resonance of 1 H and the CF 2 groups of the PFOB spectrum (-representing 12 of 17 total 19 F nuclei per PFOB molecule) [20]. Using a highly oversampled 3D radial readout scheme, the 19 F/ 1 H image datasets were reconstructed, post facto , by modifying the Nyquist weighting factor applied to samples in k-space to obtain an optimal balance between the signal-to-noise ratio and image resolution for the in vivo 19 F signal levels [21].…”

MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: Implications for clinical translation

“…High-resolution 1 H/ 19 F MR images were acquired at 3T (Philips Achieva) using an in-house, custom dual-tuned open birdcage transmit-receive coil 5, 6 . Simultaneous 3D 1 H/ 19 F imaging was used employing a novel steady state ultrashort echo time (UTE) technique (TE/TR=0.1 ms/1.96 ms) with the frequencies set to the resonance of 1 H and the CF 2 groups of the PFOB spectrum (representing 12 of 17 total 19 F nuclei) 7 . Using a highly oversampled 3D radial readout scheme, the reconstructed image datasets have a nominal resolution of 1.25 mm 3,8 .…”

Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine‐19 MRI

“…3, 8.8, 16) for the 45-year-old female and 61-year-old male, respectively. In one of the subjects, 53-year-old female, presumed patient movement during the scan hindered our ability to quantify cells; subject motion causes 19 F signal loss and can hinder accurate spin quantification (13).…”