Simultaneous Disorders of Thyroid and Thymus

Beddingfield, George W.; Campbell, Daniel C.; Hood, Richard H.; Dooley, Byron N.

doi:10.1016/s0003-4975(10)66267-4

Cited by 15 publications

(4 citation statements)

References 10 publications

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“…15 However, massive enlargement of the thymus detectable radiologically, as in our 2 cases, is uncommon and has been infrequently reported. 5,[16][17][18][19][20][21][22] Information is limited concerning the pathophysiologic role of the thymus in Graves disease. In a review of the literature, 2 theories emerge.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the earliest case reports describing anterior mediastinal masses associated with hyperthyroidism used median sternotomy and surgical resection of the thymus to diagnose benign thymic hyperplasia. 5,16 An association between thymic hyperplasia and Graves disease seems well established, and an anterior mediastinal mass associated with hyperthyroidism may not require resection or immediate biopsy. If an anterior mediastinal mass in a thyrotoxic patient is detected on chest radiography, CT of the chest should be performed.…”

Section: Approach To a Thymic Mass In Patients With Graves Diseasementioning

confidence: 99%

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Thymic Hyperplasia Presenting as Anterior Mediastinal Mass in 2 Patients With Graves Disease

Budavari¹,

Whitaker²,

Helmers³

2002

Mayo Clinic Proceedings

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Graves disease is an autoimmune thyroid condition characterized by the production of autoantibodies against the thyrotropin receptor. The autoantibodies mimic the effect of the hormone on thyroid cells, which stimulates autonomous production of thyroxine and triiodothyronine. It has been hypothesized that cross-reactivity of autoantibodies may result in Graves ophthalmopathy and dermopathy. A seldom-recognized feature of Graves disease is thymic hyperplasia. We report 2 patients with Graves disease and incidentally discovered anterior mediastinal masses presumed to be thymic hyperplasia. In both cases, these masses regressed spontaneously after treatment of hyperthyroidism.

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Section: Discussionmentioning

confidence: 99%

Section: Approach To a Thymic Mass In Patients With Graves Diseasementioning

confidence: 99%

Thymic Hyperplasia Presenting as Anterior Mediastinal Mass in 2 Patients With Graves Disease

Budavari¹,

Whitaker²,

Helmers³

2002

Mayo Clinic Proceedings

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“…Only a single report of two cases linking these synchronous cancers to childhood irradiation was discovered in our literature search [9] and in exhaustive reviews by others [ 1,3,4,[6][7][8][9]131. Occasional reports have noted nonmalignant tumors of the two glands [12,14] speculated to be due to similar endodermal tissues of origin [ 1 1 , 1 6 1 61.…”

Section: Discussionmentioning

confidence: 99%

Thyroid and thymic malignancy following childhood irradiation

Jensen

Antonenko

1992

Journal of Surgical Oncology

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Synchronous thyroid and thymic malignancy following childhood thymic irradiation has only been reported in two known cases previously, with a third case identified here. A rationale is presented for following these radiated patients as they age with thyroglobulin and thyroid-stimulating hormone (TSH) levels as a measure of risk of the development of nodular thyroid disease and, if such occurs, for an aggressive surgical approach. There exists a growing population at risk attributable to the success of radiation treatment of Hodgkin's and pediatric head and neck tumors. The question is raised regarding the theoretical benefits of thyroid suppressive therapy in this group at risk. With the instructive case presented, radical surgery for either thymic or thyroid carcinoma and careful monitoring for decades-late local recurrences of thymoma are suggested.

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“…Although modest thymic enlargement occurs in many patients with Graves's disease,' rarely is the enlargement great enough to lead to a clinical diagnostic dilemma. 2 We report here two patients with thyrotoxicosis, presumably due to Graves's disease, and an enlarged thymus gland. One patient underwent thoracotomy and removal of a considerably enlarged, histologically normal thymus.…”

mentioning

confidence: 86%