Simultaneous differential pulse voltammetric detection of uric acid and melatonin based on a self-assembled Au nanoparticle–MoS2 nanoflake sensing platform

Selvam, Sathish Panneer; Mahajan, Hansa; Yun, Kyusik

doi:10.1016/j.snb.2020.127683

Cited by 63 publications

(23 citation statements)

References 51 publications

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“…As Figure b shows, the oxidation peak current linearly increases with the consecutive addition of Me up to 50 μM ( R 2 > 0.99). At higher concentrations, the data offset from the linear behavior can be due to the saturation of the electrode active sites . The slope of the line represents a sensitivity of 5.839 μA μM –1 (or 16.219 μA μM –1 cm –2 for the geometrical surface area of 0.36 mm 2 ).…”

Section: Resultsmentioning

confidence: 97%

“…At higher concentrations, the data offset from the linear behavior can be due to the saturation of the electrode active sites. 62 The slope of the line represents a sensitivity of 5.839 μA μM −1 (or 16.219 μA μM −1 cm −2 for the geometrical surface area of 0.36 mm 2 ). The limit of detection (LOD) and the limit of quantification (LOQ) are 0.0082 and 0.0274 μM, respectively.…”

Section: Aucl 3ementioning

confidence: 99%

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Sensitive Voltammetric Detection of Melatonin in Pharmaceutical Products by Highly Conductive Porous Graphene-Gold Composites

Rahmati

Hemmati

Rahim

et al. 2020

ACS Sustainable Chem. Eng.

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This work presents a novel melatonin sensor based on unfunctionalized macroporous graphene networks decorated with gold nanoparticles for the differential pulse voltammetric detection of melatonin in pharmaceutical products. Highly porous graphene structures were prepared by metallic template-assisted chemical vapor deposition, and their active surface area and electrocatalytic activity were improved by electrochemical deposition of gold nanoparticles (50−250 nm) on their struts. The graphene-gold electrodes present a highly sensitive performance toward electro-oxidation of melatonin with a wide linear range of 0.05−50 μM, a low detection limit of 0.0082 μM (3σ/m), and a significant sensitivity of 16.219 μA μM −1 cm −2 . Therefore, the performance of the sensor regarding the obtained figures of merit is better than many other electrodes utilized for melatonin detection. The electrochemical active surface area of the glassy carbon electrode was multiplied by 18, and the high conductivity of gold-graphene composites and their synergistic catalytic effect lowered electron transport resistance by 87%. Moreover, long-term signal stability for about 14 days, acceptable reproducibility (relative standard deviation (RSD) of 4.70%), repeatability (RSD of 0.14%), and selectivity of the electrodes with various interfering materials are demonstrated. The valid potential application of the sensors for the determination of melatonin in pharmaceutical samples is shown.

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Section: Resultsmentioning

confidence: 97%

Section: Aucl 3ementioning

confidence: 99%

Sensitive Voltammetric Detection of Melatonin in Pharmaceutical Products by Highly Conductive Porous Graphene-Gold Composites

Rahmati

Hemmati

Rahim

et al. 2020

ACS Sustainable Chem. Eng.

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“…Gomez et al 81 detected melatonin and serotonin in pharmaceutical samples. In this study, graphene was utilized as a base material due to its high electrical conductivity and surface area.…”

Section: Dpv-based Detection Of Melatoninmentioning

confidence: 99%

Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin

Khan¹,

Hong²,

Lee³

et al. 2021

IJN

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Tryptophan and melatonin are pleiotropic molecules, each capable of influencing several cellular, biochemical, and physiological responses. Therefore, sensitive detection of tryptophan and melatonin in pharmaceutical and human samples is crucial for human wellbeing. Mass spectrometry, high-performance liquid chromatography, and capillary electrophoresis are common methods for both tryptophan and melatonin analysis; however, these methods require copious amounts of time, money, and manpower. Novel electrochemical and optical detection tools have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. Recently, researchers have designed sensitive and selective electrochemical and optical platforms by using new surface modifications, microfabrication techniques, and the decoration of diverse nanomaterials with unique properties for the detection of tryptophan and melatonin. However, there is a scarcity of review articles addressing the recent developments in the electrochemical and optical detection of tryptophan and melatonin. Here, we provide a critical and objective review of high-sensitivity tryptophan and melatonin sensors that have been developed over the past six years (2015 onwards). We review the principles, performance, and limitations of these sensors. We also address critical aspects of sensitivity and selectivity, limit and range of detection, fabrication process and time, durability, and biocompatibility. Finally, we discuss challenges related to tryptophan and melatonin detection and present future outlooks.

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“…Functionalizing 2D MoS 2 with Al, Cu, Sn, and Ti, Selvam et al developed a low-cost, ultra-selective biosensor for the detection of four vital neurological drugs, aspirin, nicotine, caffeine, and tramadol, in saliva [ 94 ]. The different sensors were arranged in an array for fabricating an electronic tongue (E-Tongue).…”

Section: Mo-based 2d Layered Materials For Electrochemical Biomolementioning

confidence: 99%

Mo-Based Layered Nanostructures for the Electrochemical Sensing of Biomolecules

Zribi

Neri

2020

Sensors

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Mo-based layered nanostructures are two-dimensional (2D) nanomaterials with outstanding characteristics and very promising electrochemical properties. These materials comprise nanosheets of molybdenum (Mo) oxides (MoO2 and MoO3), dichalcogenides (MoS2, MoSe2, MoTe2), and carbides (MoC2), which find application in electrochemical devices for energy storage and generation. In this feature paper, we present the most relevant characteristics of such Mo-based layered compounds and their use as electrode materials in electrochemical sensors. In particular, the aspects related to synthesis methods, structural and electronic characteristics, and the relevant electrochemical properties, together with applications in the specific field of electrochemical biomolecule sensing, are reviewed. The main features, along with the current status, trends, and potentialities for biomedical sensing applications, are described, highlighting the peculiar properties of Mo-based 2D-nanomaterials in this field.

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Simultaneous differential pulse voltammetric detection of uric acid and melatonin based on a self-assembled Au nanoparticle–MoS2 nanoflake sensing platform

Cited by 63 publications

References 51 publications

Sensitive Voltammetric Detection of Melatonin in Pharmaceutical Products by Highly Conductive Porous Graphene-Gold Composites

Sensitive Voltammetric Detection of Melatonin in Pharmaceutical Products by Highly Conductive Porous Graphene-Gold Composites

Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin

Mo-Based Layered Nanostructures for the Electrochemical Sensing of Biomolecules

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