Simultaneous development of Kaposi's sarcoma and lymphoma in a renal transplant recipient

Sabeel, A; Qunibi, Wajeh Y.; Alfurayh, Osman; Almeshari, Khalid

doi:10.1053/ajkd.1998.v31.pm9531190

Cited by 10 publications

(7 citation statements)

References 4 publications

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“…However, the authors failed to mention the possibility of the aggressive nature and multi-organ involvement of visceral KS in immunocompromised patients regardless of HIV and/or HAART as poor clinical outcome, similar to our cases, had been observed among liver and renal transplant recipients, elderly patients and other HIV-negative individuals. [2][3][4][5][6] Furthermore, an association of KS with other lymphoproliferative disorders such as lymphoma or multicentric Castleman's disease linked to the same causative agent, HIV 8 virus, should have been mentioned in the article, as this can also lead to protracted clinical course and fatal outcome in these patients, although this association is unlikely in their patient. 4,7 M Kawsar Kaposi's sarcoma associated with highly active antiretroviral therapy…”

Section: Disclosure Of Antenatal Hiv Testing Resultsmentioning

confidence: 99%

“…[2][3][4][5][6] Furthermore, an association of KS with other lymphoproliferative disorders such as lymphoma or multicentric Castleman's disease linked to the same causative agent, HIV 8 virus, should have been mentioned in the article, as this can also lead to protracted clinical course and fatal outcome in these patients, although this association is unlikely in their patient. 4,7 M Kawsar Kaposi's sarcoma associated with highly active antiretroviral therapy…”

Section: Disclosure Of Antenatal Hiv Testing Resultsmentioning

confidence: 99%

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Fatal Kaposi's sarcoma-associated immune reconstitution following highly active antiretroviral therapy

Kawsar¹

2005

Int J STD AIDS

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Section: Disclosure Of Antenatal Hiv Testing Resultsmentioning

confidence: 99%

Section: Disclosure Of Antenatal Hiv Testing Resultsmentioning

confidence: 99%

Fatal Kaposi's sarcoma-associated immune reconstitution following highly active antiretroviral therapy

Kawsar¹

2005

Int J STD AIDS

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“…Interestingly, one of the patients developed both cutaneous Kaposi's sarcoma and primary NHL of the liver. Simultaneous development of both malignancies is extremely rare and only few cases have been reported in the literature (Sabeel et al, 1998;Yaich et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Posttransplant Malignancies in Renal Transplant Recipients: 22-years Experience from a Single Center in Pakistan

Yunus

Aziz²,

Mubarak³

2012

Asian Pacific Journal of Cancer Prevention

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Objective: To study the incidence, types and distribution pattern of malignant tumors in renal transplant recipients at a single center in Pakistan. Materials and methods: This retrospective study was conducted at Sindh Institute of Urology and Transplantation (SIUT) and included all transplant patients on regular follow-up from November 1986 to December 2008. The original biopsy reports and case files of all patients who developed posttransplant malignancies were reviewed and relevant demographic, clinical, radiological, and histopathological data were retrieved and analyzed. SPSS version 10.0 was used for statistical analysis. Results: Over 22 years of study period, 1816 renal transplants were carried out at our center. Among these, 44 patients developed malignancies constituting an overall incidence rate of 2.4%. All patients in this study were males with a mean age of 34.9±9.5 years (range: 9 to 60 years). The most common type of malignancy was lymphoma (27 patients, 61.4%), followed by Kaposi's sarcoma (11 patients, 25%) and skin malignancies (3 patients, 6.8%). One case each of adenocarcinoma of the gallbladder, acute myeloid leukemia (AML), conjunctival carcinoma-in-situ and seminoma were also diagnosed. Conclusion: Posttransplant malignancies occurring in our renal transplant recipients show different incidence rates and patterns as compared with western studies.

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“…Simultaneous occurrence of lymphoma and KS in the same lymph node biopsy is interesting and has been described in rare HIV and non-HIV patients and in a rare case after renal transplantation. 12 FL is a rare lymphoma subtype to occur with KS. A rare case of mucosa-associated lymphoid tissue lymphoma and KS has been described.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Follicular Lymphoma, Kaposi Sarcoma, and Castleman’s Disease in a HIV-Negative Patient With EBV and HHV-8 Coinfection

et al. 2009

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The authors describe the case of a 65-year-old woman who was HIV negative and had a lymph node biopsy that showed concurrent follicular lymphoma (FL; grade 3A), Kaposi sarcoma (KS), and Castleman's disease (CD) with coinfection by human herpes virus-8 (HHV-8) and Epstein-Barr virus (EBV). The lymphoma was positive for CD20, CD10, and BCL6 and negative for BCL2. Flow cytometry showed a clonal lambda B-cell population, and polymerase chain reaction (PCR) showed a clonal immunoglobulin heavy chain gene rearrangement, confirming a neoplastic B-cell process. Focally, the FL component showed numerous EBER1-positive cells, with rare HHV-8-positive cells. The KS component showed strong HHV-8 expression with rare EBER1-positive cells. The CD component showed scattered HHV-8, viral interleukin-6, and EBER1-positive cells. The simultaneous occurrence of a FL, KS, and CD in an HIV-negative patient expands the spectrum of HHV-8-positive neoplasms and suggests the possibility of HHV-8 rendering mature B-cells hyperresponsive to antigenic stimulation, providing an expanded target for second site mutations or cytokine-driven hyperplasia, culminating in lymphoma.

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Simultaneous development of Kaposi's sarcoma and lymphoma in a renal transplant recipient

Cited by 10 publications

References 4 publications

Fatal Kaposi's sarcoma-associated immune reconstitution following highly active antiretroviral therapy

Fatal Kaposi's sarcoma-associated immune reconstitution following highly active antiretroviral therapy

Posttransplant Malignancies in Renal Transplant Recipients: 22-years Experience from a Single Center in Pakistan

Synchronous Follicular Lymphoma, Kaposi Sarcoma, and Castleman’s Disease in a HIV-Negative Patient With EBV and HHV-8 Coinfection

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