Simultaneous determination of water-soluble vitamins in a vitamin-enriched drink by an in-capillary enzyme reaction method

Simultaneous and accurate determination of water- and fat-soluble vitamins in multivitamin tablets by using an RP-HPLC method

“…Therefore, the quality control of multivitamin tablets is very important, and the widespread use of multivitamin preparations has stimulated research into the development of accurate, efficient, and easy methods for quality control. 4,5 The standard 6 and official analytical methods for vitamin analysis 7 are tedious and involve a pre-treatment of the sample through complex chemical, physical, or biological reactions in order to eliminate interference of other constituents in the vitamin, which is typically followed by individual methods for each different vitamin. Many analytical methods, such as those based on UV-Vis spectrophotometry, 8 fluorimetry, 9 chemiluminiscence, 10 capillary electrophoresis, 11 microbiology, 12 and high-performance liquid chromatography [13][14][15][16][17] have been proposed only for the determination of water-soluble or fat-soluble vitamins and are tedious, sometimes nonspecific, and time-consuming.…”

Polarographic Behavior of Nicotinamide in Surfactant Media and Its Determination in Cetyltrimethylammonium Bromide Surfactant System

“…A method has therefore been developed for the simultaneous determination of nicotinamide and pyridoxine hydrochloride in the CTAB media. Even though various micellar electrokinetic chromatographic 6,[27][28][29] and capillary electrophoretic 30 methods have been reported for the simultaneous determination of nicotinamide along with other vitamins, no electrochemical method has been reported for the simultaneous determination of nicotinamide and pyridoxine hydrochloride in surfactant media.…”

CE methods applied to the analysis of micronutrients in foods

“…Okamoto et al [87] simultaneously determined riboflavin, thiamin, pyridoxine and nicotinamide in a vitaminenriched drink using an in-capillary enzyme reaction method. In this system 'sandwich mode' injection was employed whereby a plug of sandwich solution without SDS was introduced into the capillary first, followed by plugs of substrate solution, enzyme solution and sandwich solution again.…”