Simultaneous Determination of Verapamil Hydrochloride and Gliclazide in Synthetic Binary Mixture and Combined Tablet Preparation by Chemometric-Assisted Spectroscopy

Bhaskar, Rahul; Bhaskar, Radhika; Sagar, Mahendra K.; Saini, Vipin; Bhat, Krishnamurthy

doi:10.4236/jasmi.2012.23026

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…The absorption is quantified by the Beer-Lambert law, which relates the absorbance to the concentration of the absorbing species. (9,10,11)  Measurement Process: The instrument measures the intensity of light before and after it passes through the sample. The difference in intensity corresponds to the amount of light absorbed by the sample.…”

Section: A Novel Development and Validation Of Differential Spectroph...mentioning

confidence: 99%

A Novel Development and Validation of Differential Spectrophotometric Method for Determination of Domperidone in Tablet Dosage Form

Khant,

Viroja,

Jani

2023

Preprint

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The amount of domperidone in pharmaceutical dose forms was measured using a straightforward, quick, and sensitive differential spectrophotometric approach. The approach is based on the uv- spectra-differentiated caused spectrum changes that occur when the ph of the medium is changed. To determine the amplitude, the absorbance difference between these two maxima was measured and plotted against concentration. With a detection limit of 0.15 g/ml, the calibration curve is linear over the concentration range of 2 to 10 µg/ml (r2 = 0.997) without the common element that comes with the drug interfering, the procedure was effectively applied to the commercial pharmaceutical drug. The outcome when statistically compared to the outcomes of the standard method. The assay of domperidone in pure and tablet dosage form was completed satisfactorily using the suggested procedures. The assay of domperidone in its pure form and in tablet dosage form was successfully conducted using the suggested procedures. Tablet excipients did not cause any interference when tested under the specified assay conditions and wavelengths. Statistics revealed no difference between the data and those acquired using the spectrophotometric approach described in the literature.

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Section: A Novel Development and Validation Of Differential Spectroph...mentioning

confidence: 99%

A Novel Development and Validation of Differential Spectrophotometric Method for Determination of Domperidone in Tablet Dosage Form

Khant,

Viroja,

Jani

2023

Preprint

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“…It showed that the cooking process can affect the chemical properties of pork. The unsaturated fatty acids of pork may degrade during the heating process because pork corned is not separated from beef corned (Bhaskar et al, 2012). Therefore, halal authentication using FTIR combined with chemometrics has a problem if the product is carried out by different process because they are possible to degrade during the process (El-Gindy, Emara, and Mostafa, 2006).…”

Section: Analysis Of Pork Adulteration In Commercial Corned Productsmentioning

confidence: 99%

Analysis of pork adulteration in the corned products using FTIR associated with chemometrics analysis

Guntarti

Ahda

Kusbandari

et al. 2020

Potr. S. J. F. Sci.

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Meat-based foods such as beef corned became one of the targets of counterfeiting with pork because relatively cheaper. This becomes a serious problem for Muslims, especially in Indonesia. One method that can be used to detect fat was Fourier transform infrared (FTIR) spectrophotometry. The purpose of this study was to quantitatively analyze and a group of corned beef and corned pork using FTIR spectrophotometry combined with chemometrics. Reference samples corned pork-beef made of 7 various concentration (0%, 25%, 35%, 50%, 65%, 75%, 100%) and 6 product samples purchased in the Umbulharjo, Yogyakarta. Extraction was carried out by the soxhlet apparatus using n-hexane technical solvent for 4 – 5 hours at 69 – 70 °C. Fat analyzed using FTIR spectrophotometry for generating infrared spectral data then processed with Partial least square (PLS) chemometrics for quantitative analysis and Principal component analysis (PCA) for grouping. Results of quantitative analysis chemometrics PLS, selected areas fingerprints for analysis corned pork-beef was 1180 – 730 cm-1 with R2 0.9833; RMSEC 2.06%; RMSEP 1.65% and RMSECV 2.22%. The results of PCA showed groupings in different quadrants between corned pork 100% and corned beef 100%. Results showed that FTIR spectrophotometry combined with chemometrics can be used for quantitative analysis and grouping of pork corned and beef corned on the market but it can not identify pork in corned after choking process.

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“…Solubilizing poor water-soluble drugs are a major challenge in pharmaceutical research. [1] Lipid-based drug formulations increase the relative solubility of drugs in gastrointestinal (GI) track by enhancing absorption. Self-nano-emulsifying drug-delivery systems (SNEDDSs) lipid-based formulations are most promising technology in drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

AJP

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Introduction:The present study deals with the development and characterization of self-nano-emulsifying drugdelivery system (SNEDDS) to improve the oral bioavailability of water-insoluble biopharmaceutical classification system Class II drug verapamil. The objectives of the study are to develop SNEDDS of verapamil and to characterize for particle size, self-nano-emulsification, and dissolution enhancement. Solubility of verapamil was determined in various oils, surfactants, and cosurfactants. Materials and Methods: Captex 355 was selected as an oil phase, acrysol K140 as surfactant, and PEG400 as cosurfactant due to their higher solubilization effect. Results: Various formulations were prepared by simple mixing followed by vortexing. From studies, the optimized SNEDDS formulation was composed of verapamil (9.13% w/w), captex 355 (23.41% w/w), acrysol K140 (51.62% w/w), and PEG 400 (11.58% w/w). The selected SNEDDS could be self-emulsified without precipitation on simple mixing. The mean particle size of the SNEDDS was 148.7 nm and percent drug content was 99.66. The in vitro dissolution of verapamil from SNEDDS was found to be significantly higher (95.4 ± 2.07) in comparison to the marketed tablet (64.8 ± 1.36) and pure drug (52.5 ± 1.65) in 0.1 N HCl as dissolution medium. Conclusion: The results indicate that SNEDDS of verapamil, due to its nanosized, has potential to enhance the absorption of drug due to its higher dissolution.

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Simultaneous Determination of Verapamil Hydrochloride and Gliclazide in Synthetic Binary Mixture and Combined Tablet Preparation by Chemometric-Assisted Spectroscopy

Cited by 7 publications

References 11 publications

A Novel Development and Validation of Differential Spectrophotometric Method for Determination of Domperidone in Tablet Dosage Form

A Novel Development and Validation of Differential Spectrophotometric Method for Determination of Domperidone in Tablet Dosage Form

Analysis of pork adulteration in the corned products using FTIR associated with chemometrics analysis

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