Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography

Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies

“…The characterization of the acid-base properties of this substance is given elsewhere [10]. Various analytical methods for the determination of triflusal and HTB have been proposed based on liquid chromatography using C 18 bonded silica columns and hydro-organic eluting mobile phases [11,12].…”

In vitro and in vivo performance of a dual drug-eluting stent (DDES)

“…Triflusal has a chemical structure closely related to aspirin and has structural features that irreversibly deactivate the aggregation process in platelets to inhibit cellular thrombus, by inhibiting platelet cyclooxigenase activity. Triflusal is known to quickly metabolize into its major metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, which also displays anti-aggregation activity [16,17,39]. Additionally, the triflusal release profile of the test stent with the dual sirolimustriflusal (D3) showed very fast release with 60% initial burst at 1 day and more than 90% subsequent release up to 3 days.…”

“…Triflusal (2-acetoxy-4-trifluoromethylbenzoic acid) is a powerful platelet aggregation inhibitor with a chemical structure closely related to salicylic acid or aspirin. The latter contains acetyl groups which prevents platelets aggregation, by an irreversible inhibition of platelet cyclooxigenase activity [16,17]. Poly (D, L-lacticco-glycolic acid) (PLGA) has been extensively used as a controlled release carrier for drug delivery, due to its good biocompatibility, biodegradability and mechanical strength [18][19][20].…”

Development and Validation of Rp-HPLC Method for the Estimation of Triflusal in Bulk and in Capsule Formulation

“…The detail literature survey revealed few analytical methods reported for evaluation TRI such as HPLC [3][4][5] . HPLC with automated column switching system 6 , spectroscopic and chromatographic characterization using supercritical impregnation technologies 7,8 .…”