Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography—tandem mass spectrometry

Li, Shuijun; Liu, Gangyi; Jia, Jingying; Liu, Yun; Pan, Cheng; Chen, Yu; Cai, Yongbao; Ren, Jianying

doi:10.1016/j.jchromb.2006.10.013

Cited by 92 publications

(51 citation statements)

References 23 publications

(18 reference statements)

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“…Several gas chromatographic (Quaglio et al, 1993;Black et al, 1996;Hartonen and Riekkola, 1996;Amendola et al, 2000) and liquid chromatographic (Naidong et al, 2002;Maurer et al, 2004;do Carmo Borges et al, 2005;Josefsson and Sabanovic, 2006;Keski-Rahkonen et al, 2007;Li et al, 2007;Ding et al, 2007;Fanali et al, 2007) methods coupled to mass spectrometry, including tandem mass spectrometry (MS-MS), have been developed in order to determine the levels of acebutolol, labetalol, metoprolol and propranolol in biological samples. These methods utilized liquid-liquid extraction (LLE; Amendola et al, 2000;do Carmo Borges et al, 2005;KeskiRahkonen et al, 2007;Li et al, 2007) or off-line solidphase extraction (SPE; Quaglio et al, 1993;Black et al, 1996;Hartonen and Riekkola, 1996;Naidong et al, 2002;Maurer et al, 2004;Josefsson and Sabanovic, 2006) for specimen preparation and concentration prior to chromatography.…”

Section: Introductionmentioning

confidence: 99%

“…These methods utilized liquid-liquid extraction (LLE; Amendola et al, 2000;do Carmo Borges et al, 2005;KeskiRahkonen et al, 2007;Li et al, 2007) or off-line solidphase extraction (SPE; Quaglio et al, 1993;Black et al, 1996;Hartonen and Riekkola, 1996;Naidong et al, 2002;Maurer et al, 2004;Josefsson and Sabanovic, 2006) for specimen preparation and concentration prior to chromatography. However, LLE and off-line SPE methods are laborious and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of β‐blockers in human plasma using liquid chromatography–tandem mass spectrometry

Umezawa

Lee

Arima

et al. 2008

Biomedical Chromatography

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A detailed procedure for the analysis of four beta-blockers, acebutolol, labetalol, metoprolol and propranolol, in human plasma by high-performance liquid chromatography (LC)-tandem mass spectrometry (MS-MS) using an MSpak GF column, which enables direct injection of crude plasma samples, is presented. Protein and/or macromolecule matrix compounds were eluted first from the column, while the drugs were retained on the polymer stationary phase of the MSpak GF column. The analytes retained on the column were then eluted into an acetonitrile-rich mobile phase using a gradient separation technique. All drugs showed base peak ions due to [M + H]+ ions by LC-MS with positive ion electrospray ionization, and the product ions were produced from each [M + H]+ ion by LC-MS-MS. Quantification was performed by selected reaction monitoring. The recoveries of the four beta-blockers spiked into plasma were 73.5-89.9%. The regression equations for all compounds showed excellent linearity in the range 10-1000 ng/mL of plasma, with the exception of propranolol (10-800 ng/mL). The limits of detection and quantification for each drug were 1-3 and 10 ng/mL, respectively, of plasma. The intra- and inter-day coefficients of variation for all drugs in plasma were not greater than 10.9%.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of β‐blockers in human plasma using liquid chromatography–tandem mass spectrometry

Umezawa

Lee

Arima

et al. 2008

Biomedical Chromatography

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“…Li et al reported a method that used liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the detection of MEX. 15 LC-MS/MS is sensitive and selective, but also expensive.…”

Section: Introductionmentioning

confidence: 99%

Column-Switching HPLC Determination of Mexiletine Using Tris(bipyridine)ruthenium(III) Electrogenerated Chemiluminescence and Precolumn Derivatization with Divinylsulfone

2010

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“…Some of them employ fluorescence detection [3][4][5][6][7][8][9][10], very few employ spectrophotometric detection in the UV range [11,12], whereas mass spectrometric detection is used in the recent developed methods [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…As for the sample preparation procedures employed prior to the HPLC determination of verapamil, there is a diversity in the speed and complexity of the clean-up methods starting from direct determination of verapamil from rat plasma [7], through using only deproteinization of the plasma samples [11,13] to the more complex ones such as liquid-liquid extraction (LLE) using various organic solvents [3,4,6,9,10,15] and solid-phase extraction (SPE) with various adsorbents [4,8,9,17]. The most sophisticated sample preparation procedures employ automated column switching techniques for on-line sample preparation [5,7,8,12].…”

Section: Introductionmentioning

confidence: 99%

HPLC method for determination of verapamil in human plasma after solid-phase extraction

Ivanova

Zendelovska

Стефова

et al. 2008

Journal of Biochemical and Biophysical Methods

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A simple, rapid and precise HPLC method has been developed for the assay of verapamil in human plasma. The clean up of the plasma samples was tested using several adsorbents for solid-phase extraction and best recovery was obtained using mixed-mode cartridges (HLB -hydrophilic-lipophilic balance) ranging between 94.70 and 103.71%. HPLC separation was performed with isocratic elution on Lichrospher 60 RP-select B column (250 mm × 4 mm I.D., 5 μm particle size). The mobile phase was 40% acetonitrile and 0.025 mol/L KH 2 PO 4 with pH 2.5 at flow rate of 1 mL/min. Diltiazem was used as internal standard and the detection wavelength was 200 nm. The calibration curves were linear in the range of 10-500 ng/mL. The developed method is convenient for routine analysis of verapamil in human plasma.

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Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography—tandem mass spectrometry

Cited by 92 publications

References 23 publications

Simultaneous determination of β‐blockers in human plasma using liquid chromatography–tandem mass spectrometry

Simultaneous determination of β‐blockers in human plasma using liquid chromatography–tandem mass spectrometry

Column-Switching HPLC Determination of Mexiletine Using Tris(bipyridine)ruthenium(III) Electrogenerated Chemiluminescence and Precolumn Derivatization with Divinylsulfone

HPLC method for determination of verapamil in human plasma after solid-phase extraction

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