Simultaneous determination of seven flavonoids, two phenolic acids and two cholesterines in Tanreqing injection by UHPLC-MS/MS

Cui, Li; Zang, Chen; Nie, Qiulin; Yang, Bo; Zhang, Baoxian; Duan, Shaofeng

doi:10.1016/j.jpba.2018.08.058

Cited by 25 publications

(15 citation statements)

References 13 publications

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“…The main ingredients in honeysuckle exhibit antibacterial and antiviral activities [ 30 , 31 , 32 ]. Luteolin is the main flavonoid in honeysuckle [33] . TCM may be an effective alternative treatment for respiratory infections.…”

Section: Introductionmentioning

confidence: 99%

Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking

Liang

Liu

et al. 2020

International Journal of Antimicrobial Agents

232

188

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Introductionmentioning

confidence: 99%

Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking

Liang

Liu

et al. 2020

International Journal of Antimicrobial Agents

232

188

View full text Add to dashboard Cite

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“…Through literature research [11,[20][21][22][23][24][25][26][27]and using the list of chemical components supplied by the manufacturer (Shanghai Kaibao Pharmaceutical Co,Ltd,Shanghai,China),29 compounds in TRQ were chosen for further study. All compounds were fed into PubChem [28,29] (https://pubchem.ncbi.nlm.nih.gov).…”

Section: Chemical Composition Of Trqmentioning

confidence: 99%

A Network Pharmacology-based Analysis of the Molecular Mechanism of Tanreqing in the Treatment of the Coronavirus Disease 2019 (COVID-19)

Yang

Wen

Zheng

et al. 2020

Preprint

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Background: This paper discusses the molecular mechanism of Tanreqing (TRQ) in the treatment of the coronavirus disease 2019 (COVID-19) using the network pharmacology approach. Our study provides new ideas on the laboratory research and clinical treatment of the disease. Method: Information on the chemical constituents of TRQ and the genes targeted by the disease was collected. The common gene targets of the drug and the disease were input into the Search Tool for the Retrieval of Interacting Genes/Proteins（STRING）database to understand the interaction among target proteins. The protein–protein interaction (PPI) network and a network of the chemical constituents of TRQ and their targets were constructed using Cytoscape. Gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed using the R program and other relevant software packages. Results: Twenty-eight active chemical constituents and 365 gene targets were identified for TRQ. Out of these genes, 113 were also found to be involved in the pathogenesis of the disease. Enrichment analysis revealed the therapeutic role that TRQ could have played in the treatment of COVID-19, via the regulation of important pathways such as the renin–angiotension system, neuroactive ligand–receptor interaction, phospholipase D (PLD) signaling pathway, calcium signaling pathway, and the hypoxia-inducible factor 1 (HIF-1) signaling pathway. Conclusions: This study attempts to predict the molecular mechanism of TRQ in the treatment of COVID-19, and suggests TRQ intervention through multiple targets and pathways in processes including inflammatory response, immune regulation, and apoptosis during the treatment of the disease. This study indicates the potential rational application of TRQ in the clinical treatment of COVID-19.

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“…Based on the above reasons, it is necessary to explore a convenient and sensitive method for detecting the presence and content of LU for chemical and medical research [7]. During many years of research, various methods for detecting LU have been conducted, such as high performance liquid chromatography, spectrophotometry, gas chromatography, have been conducted, such as high performance liquid chromatography, spectrophotometry, gas chromatography, electrochemical methods, capillary electrophoresis, and so on [8][9][10]. In these methods, electrochemical analysis showed considerable advantages including fast response, low consumption, simple operation, accuracy and selectivity [11].…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Electrochemical Sensor for Luteolin Based on Zirconium Metal-Organic Framework UiO-66/Reduced Graphene Oxide Composite Modified Glass Carbon Electrode

Wang

et al. 2020

Molecules

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Luteolin is a kind of natural flavonoid with many bioactivities purified from a variety of natural herbs, fruits and vegetables. Electrochemical sensing has become an outstanding technology for the detection of luteolin in low concentration due to its fast response, easy operation and low cost. In this study, electroreduced graphene oxide (ErGO) and UiO-66 were successively modified onto a glassy carbon electrode (UiO-66/ErGO/GCE) and applied to the detection of luteolin. A combination of UiO-66 and ErGO showed the highest promotion in the oxidation peak current for luteolin compared with those of a single component. The factors affecting the electrochemical behavior of UiO-66/ErGO/GCE were evaluated and optimized including pH, accumulation potential, accumulation time and scan rate. Under optimum conditions, UiO-66/ErGO/GCE showed satisfactory linearity (from 0.001 μM to 20 μM), reproducibility and storage stability. The detection limit of UiO-66/ErGO/GCE reached 0.75 nM of luteolin and was suitable for testing real samples. Stable detection could be provided at least eight times by one modified electrode, which guaranteed the practicability of the proposed sensor. The fabricated UiO-66/ErGO/GCE showed a rapid electrochemical response and low consumption of materials in the detection of luteolin. It also showed satisfactory accuracy for real samples with good recovery. In conclusion, the modification using MOFs and graphene materials made the electrode advanced property in electrochemical sensing of natural active compounds.

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Simultaneous determination of seven flavonoids, two phenolic acids and two cholesterines in Tanreqing injection by UHPLC-MS/MS

Cited by 25 publications

References 13 publications

Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking

Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking

A Network Pharmacology-based Analysis of the Molecular Mechanism of Tanreqing in the Treatment of the Coronavirus Disease 2019 (COVID-19)

Ultrasensitive Electrochemical Sensor for Luteolin Based on Zirconium Metal-Organic Framework UiO-66/Reduced Graphene Oxide Composite Modified Glass Carbon Electrode

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