Simultaneous determination of scopolamine and butylscopolamine in pharmaceutical and beverage samples by capillary zone electrophoresis

Capillary electromigration methods for food analysis and Foodomics: Advances and applications in the period March 2021 to March 2023

“…C 4 D facilitated the detection of both compounds because it is a system that provides the detection of compounds with different conductivities than BGE. Thus, a BGE with high conductivity was selected (an organic acid with NaOH to adjust the pH) for the detection of organic cations in the samples [102]. Concerning ketamine, it is a drug that usually is found in blood or beverages, and it is important for the sample collection and conservation during large period of times for the forensic evaluation [103].…”

“…On the other hand, some drugs are used medicinally, but they also are used for criminal purposes, such as scopolamine or ketamine that facilitate theft and sexual crimes due to their sedative effects [102,103]. In particular, to avoid the negative effects of scopolamine, scopolamine quaternary amine compounds have been synthetized, such as butylscopolamine [102]. However, different patients have been diagnosticated with intoxication symptoms by this quaternary amine.…”

LC–MS/MS approach for simultaneous assessment of hyoscine N‐butyl bromide and ketoprofen in biological fluids and pharmaceuticals

“…Moreover, these HPLC methods have not been tested in human biological fluids for therapeutic drug monitoring. On the contrary, many chromatographic techniques as well as spectrophotometric methods for HBB or KTP alone and in combination with other drugs have been stated (Ahmed et al, 2018; Ali et al, 2012; Andraws & Trefi, 2020; Chang et al, 2000; Cherkaoui et al, 1999; Dvořák et al, 2004; Erk & Onur, 1996; Favreto et al, 2012; Gherdaoui et al, 2016; Karali et al, 1998; Lau & Mok, 1997; Özlü et al, 2005; Ribeiro et al, 2022; Tandel et al, 2018; Tsvetkova & Peikova, 2014). Therefore, the scientific interest arose to develop and validate an ultrasensitive, precise, accurate and reliable method for the simultaneous analysis of HBB and KTP that can be applied fruitfully for regular analysis in pharmaceuticals as well as human biological fluids.…”

“…Moreover, these HPLC methods have not been tested in human biological fluids for therapeutic drug monitoring. On the contrary, many chromatographic techniques as well as spectrophotometric methods for HBB or KTP alone and in combination with other drugs have been stated (Ahmed et al, 2018;Ali et al, 2012;Andraws & Trefi, 2020;Chang et al, 2000;Cherkaoui et al, 1999;Dvořák et al, 2004;Erk & Onur, 1996;Favreto et al, 2012;Gherdaoui et al, 2016;Karali et al, 1998;Lau & Mok, 1997;Özlü et al, 2005;Ribeiro et al, 2022;Tandel et al, 2018;Tsvetkova & Peikova, 2014).…”

Dualplex lateral flow assay for simultaneous scopolamine and “cannibal drug” detection based on receptor-gated mesoporous nanoparticles

“…For SCP, a wide variety of techniques have been used for its reliable identification in different adulterated samples, such as gas chromatography, 12,13 high-performance liquid chromatography 14,15 and capillary zone electrophoresis. 16 Most of these studies have been focused on the determination of SCP in serum, plasma, and other biological samples, such as urine or hair. 17 However, these analytical techniques are commonly employed in a dedicated laboratory environment, requiring sophisticated instrumentation, and cannot be used in situ or at site for instance to detect beverages spiked with an illicit drug, thus preventing unintentional consumption of this substance.…”