Simultaneous determination of risperidone and 9-hydroxyrisperidone enantiomers in human blood plasma by liquid chromatography with electrochemical detection

Analysis of risperidone and 9-hydroxyrisperidone in human plasma, urine and saliva by MEPS-LC-UV

“…Moreover, it uses feasible procedures and almost ubiquitous equipment and is thus applicable in a wide variety of clinical and research environments; previous methods often used very expensive or not easily available instrumentation and procedures, such as LC-MS [16,20,24,25], coulometric detection [14,21,26], column switching [22] or luminol chemiluminescence [23].…”

“…Several methods can be found in the literature for the analysis of RISP and 9OHR in biological fluids; most of them deal with plasma [14][15][16][17][18][19][20][21] or serum [22] and some with urine [23,24] or saliva [25,26], but none carries out the analysis in all three matrices. Moreover, many of these methods are based on expensive or uncommon instrumentation and procedures, not always available or possible in clinical laboratories, such as mass spectrometric [16,20,24,25] or coulometric detectors [14,21,26], column switching [22] or luminol chemiluminescence [23].…”

Studies on Paliperidone in OROS Tablets: Extraction Procedure and Chromatographic Analysis

“…Previous studies have described the analysis of risperidone and 9-hydroxy-risperidone in plasma, urine and serum using LC, LC/MS-MS and MEPS-LC-UV [17][18][19]. Locatelli et al [20] proposed the determination of these substances in biological fluids using HPLC methods, allowing for the simultaneous analysis of enantiomers. The method combines reversephase chiral separation and electrochemical detection, which guarantee sufficient sensitivity to investigate stereoselectivity.…”

Magnetic Solid-Phase Extraction in Combination with Ultra High-Performance Liquid Chromatography-Tandem Mass Spectrometry Analysis: Quantification of Risperidone and 9-Hydroxyrisperidone in Biological Samples

“…6,7 To date, several literatures have been reported different detection methods of RISP and 9OHR in biological samples by the use of high-performance liquid chromatography with ultraviolet detection (HPLC-UV), 8,9 high-performance liquid chromatography with diode array detection (HPLC-DAD), 10 liquid chromatography with electrochemical detection (LC-EC), 11 liquid chromatography with coulometric detection (LC-CD), 12 high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), [13][14][15] time-of-flight mass spectrometers (TOF-MS), 16 and ultrahigh pressure liquid chromatography with photodiode array detection (UPLC-PDA). 17 Because of complex pretreatment steps and time-consuming properties, some of these methods are not very suitable for clinical studies, such as liquid-liquid extraction (LLE), 8,13,15,16 solid phase extraction (SPE) 9,10,11,14 and microextraction by packed sorbent (MEPS). 12,17 Base on the interference of the complex metabolites and complicated pretreatments in biological samples, the determination of RISP and 9OHR by an appropriate adsorbent material for the enrichment is necessary.…”