Simultaneous Determination of Pyraclostrobin, Prochloraz, and its Metabolite in Apple and Soil Via RRLC-MS/MS

Fan, Xueqi; Zhao, Shengming; Chen, Xiaoxin; Hu, Jiye

doi:10.1007/s12161-017-1065-1

Cited by 18 publications

(6 citation statements)

References 30 publications

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“…Besides, attention has been paid to the change of pyraclostrobin in food processing such as rasin and paste preparation. In addition, dissipation studies have been conducted in apple, pepper, peanut, banana, grape, giving half‐lives of 1.6 to 1.7 days in maize, 3.39–4.06 days in glasshouse strawberry, 10.3–11.2 days in peanut, 17.8–25.9 days in grape …”

Section: Introductionmentioning

confidence: 99%

“…3 Different methods have been developed for the determination of pyraclostrobin, for example, gas chromatography which requires cumbersome sample preparation and large amounts of organic solvents. 4,5 Capillary electrophoresis 6 and subsequent liquid chromatography (LC) UV 7,8 and mass spectrometry (MS) [9][10][11][12][13][14] have been utilized for the determination of pyraclostrobin in different matrices, such as apple, 10 citrus, 11 pepper, 12 peanut, 13 rice, 14 grape. 9 Besides, attention has been paid to the change of pyraclostrobin in food processing such as rasin 15 and paste 16 preparation.…”

Section: Introductionmentioning

confidence: 99%

“…9 Besides, attention has been paid to the change of pyraclostrobin in food processing such as rasin 15 and paste 16 preparation. In addition, dissipation studies have been conducted in apple, 10 pepper, 12 peanut, 13 banana, 8 grape, 9 giving half-lives of 1.6 to 1.7 days in maize, 17 3.39-4.06 days in glasshouse strawberry, 18 10.3-11.2 days in peanut, 13 17.8-25.9 days in grape. 9 Cyazofamid (4-chloro-2-cyano-N,N-dimethyl-5-p-tolylimidazole-1-sulfonamide) (CAS number 120116-88-3) is a novel member of phenylimidazole fungicide, which was developed by Ishihara Sangyon Kaisha, Ltd. 19 It has been approved as an agrochemical in 17 countries in 2004.…”

Section: Introductionmentioning

confidence: 99%

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Residue behaviours, dissipation kinetics and dietary risk assessment of pyaclostrobin, cyazofamid and its metabolite in grape

Pang

Dou

2019

J Sci Food Agric

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BACKGROUND Grape is an important fruit consumed either fresh or processed, therefore, fungicide misuse of grape has become an issue of global food safety and human health. Pyraclostrobin, and cyazofamid have been applied to grape frequently. RESULTS Here a simple QuEChERS (quick, easy, cheap, effective, rugged, and safe) liquid chromatography mass spectrometry technique has been developed and validated for the determination of pyraclostrobin, cyazofamid and its metabolite CCIM in open field grape samples. The recoveries of these three in the range of 0.01 to 5 mg kg−1 (n = 5) ranged from 73.1% to 97.9%. The relative standard deviations (RSDs) were below 12% for all cases. The limits of quantitation of each analyte was 0.005 mg kg−1, which was lower than maximum residue limits of not only pyraclostrobin but also cyazofamid. Not only dissipation kinetics but also residue determination was obtained in grape for those three pesticides. Furthermore, their half‐lives in grapes were 10.7–30.1 days, recommending the pre‐harvest intervals for these three of 14 days. The calculated hazard quotient and acute hazard index lower than 100% illustrated the safety of intake of grape for the Chinese population for not only long‐term but also short‐term dietary risk assessment. CONSLUSIONS The less than 30 day half‐life illustrated that pyraclostrobin and cyazofamid could degrade relatively easily in the environment. The long‐term and short‐term dietary risk assessment also illustrated the intake safety of these three. Thus, a 14 day pre‐harvest interval was safe and recommended. The results of this study contributed to environmental protection, food safety and human health. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Residue behaviours, dissipation kinetics and dietary risk assessment of pyaclostrobin, cyazofamid and its metabolite in grape

Pang

Dou

2019

J Sci Food Agric

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“…roxburghii and soil. The reported half-lives of pyraclostrobin were 5.5~8.0 d in blueberries [ 30 ], 8.3~9.1 d in bananas [ 13 ] and 7.9~15.1 d in apples [ 31 ]. The half-lives of the same pesticide in different crops is different, which may vary with different substrates, resulting in different original residues and degradation rates.…”

Section: Resultsmentioning

confidence: 99%

Dissipation and Residues of Pyraclostrobin in Rosa roxburghii and Soil under Field Conditions

Han

2022

Foods

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Rosa roxburghii has been widely planted in China. Powdery mildew is the most serious disease of R. roxburghii cultivation. Pyraclostrobin was widely used as a novel fungicide to control powdery mildew of R. roxburghii. To assess the safety of pyraclostrobin for use on R. roxburghii fruits, its residue rapid analysis as well as an investigation on its dissipation behaviors and terminal residues in R. roxburghii and soil under field conditions were carried out. The QuEChERS method was simplified using LC–MS/MS detection and combined with liquid–liquid extraction purification to allow determination of pyraclostrobin levels in R. roxburghii fruits and the soil. The fortified recoveries at 0.1~5.0 mg/kg were 93.48~102.48%, with the relative standard deviation of 0.64~3.21%. The limit of detection of the analytical method was 0.16 and 0.15 µg/kg for R. roxburghii fruit and soil, respectively. The effects of different spray equipment and formulations on the persistence of pyraclostrobin in R.roxburghii were as follows: gaston gasoline piggyback agricultural sprayer (5.38 d) > manual agricultural backpack sprayer (3.37 d) > knapsack multi-function electric sprayer (2.91 d), suspension concentrate (SC) (6.78 d) > wettable powder (WP) (5.64 d) > water dispersible granule (WG) (4.69 d). The degradation of pyraclostrobin followed the first-order kinetics and its half-lives in R.roxburghii and soil were 6.20~7.79 days and 3.86~5.95 days, respectively. The terminal residues of pyraclostrobin in R. roxburghii and soil were 0.169~1.236 mg/kg and 0.105~3.153 mg/kg, respectively. This study provides data for the establishment of the maximum residue limit (MRL) as well as the safe and rational use of pyraclostrobin in R. roxburghii production.

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“…Several different strategies have been employed to date as a means of measuring pyraclostrobin, dimethomorph, cymoxanil, cyazofamid, and CCIM residues in particular matrices. For example, gas chromatography (GC), high performance liquid chromatography with an ultraviolet visible detector (HPLC-UV), and mass spectrometry (MS) have all been employed to measure pyraclostrobin residues in grapes and other key crops. ,− Studies using a combination of GC and MS (GC-MS), HPLC-UV, and liquid chromatography with tandem mass spectrometry (LC-MS/MS) have been conducted for measuring dimethomorph in crops including grapes. − Cymoxanil has been detected via GC, GC-MS, HPLC-UV, and LC-MS/MS in assorted food matrixes. − Both LC and LC-MS/MS have been used for cyazofamid/CCIM residue measurements in grapes and other crops. , − At present, however, there are few reports regarding efforts to simultaneously detect all five of these compounds in grape field tests. As such, there is clear value in conducting such tests to better understand the multiresidue behavior of these compounds and to conduct appropriate risk assessments.…”

Section: Introductionmentioning

confidence: 99%

Dissipation and Risk Assessment of Multiresidual Fungicides in Grapes under Field Conditions

Yang

Luo

Zhang

et al. 2019

J. Agric. Food Chem.

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Grapes are among the most popular fruits globally, and various fungicides are widely applied to grape crops. As such, the presence of multiple fungicide residues and dietary risks in grapes has become the focus of significant attention. In this study, an easy-to-implement and sensitive UPLC-MS/MS approach was developed to simultaneously determine pyraclostrobin, dimethomorph, cymoxanil, cyazofamid and its metabolite CCIM in grapes via QuEChERS. This approach achieved 78.1–106.0% recovery and a 0.01 mg kg–1 limit of quantitation (LOQ). Field trials revealed that these compounds had degradation half-lives ranging from 0.9 to 13.3 days. And their terminal residues ranging from < LOQ to 1.36 mg kg–1 were below the official maximum residue limit (MRL) in China. The short-term risk for each tested fungicide was below 54%. The long-term risk of individual chemicals ranged from 0.0086% to 3.1%, and their cumulative risk was 4.4%. Results indicated that the dietary risk of these fungicides in grapes was minor.

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Simultaneous Determination of Pyraclostrobin, Prochloraz, and its Metabolite in Apple and Soil Via RRLC-MS/MS

Cited by 18 publications

References 30 publications

Residue behaviours, dissipation kinetics and dietary risk assessment of pyaclostrobin, cyazofamid and its metabolite in grape

Residue behaviours, dissipation kinetics and dietary risk assessment of pyaclostrobin, cyazofamid and its metabolite in grape

Dissipation and Residues of Pyraclostrobin in Rosa roxburghii and Soil under Field Conditions

Dissipation and Risk Assessment of Multiresidual Fungicides in Grapes under Field Conditions

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