Simultaneous Determination of Pseudoephidrine HC1 (PSE) and Terfanidine (TER) from Formulations by Reversed-Phase Ion Pair High-Performance Liquid Chromatography (RP-HPLC)

Argekar, A. P.; Shah, S. J.; Raj, S. V.

doi:10.3109/03639049809085613

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…The eluent was monitored with an ultraviolet/visible (UV/ vis) detector set at 220 nm with a flow rate of 1.0 ml/ min (11)(12)(13). tion tester (DST-600, Fine Chemical, Seoul, Korea).…”

Section: Dissolution Testmentioning

confidence: 99%

Development of Terfenadine-Pseudoephedrine Double-Layer Tablet Dissolution-Equivalent to Core Tablet

Choi

Yong

Kim

2000

Drug Development and Industrial Pharmacy

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The terfenadine-pseudoephedrine dosage form discussed here is the sustained-release core tablet composed of outer (fast-release) and inner (sustained-release) layers. To develop the double-layer tablet dissolution-equivalent to a core tablet, the fast-release and sustained-release layers were prepared using various disintegrants and polymers, respectively. The layer composed of terfenadine/pseudoephedrine/lactose/cornstarch/sodium bicarbonate/hydroxypropylcellulose (HPC)/sodium lauryl sulfate/microcrystalline cellulose (60/10/90/30/20/1/40/1/293 mg), which gave the fast disintegration time and high dissolved amounts of drugs, was selected as the fast-release layer. The dissolved amounts of pseudoephedrine from sustained-release layers increased more with a smaller ratio of ethylcellulose and hydroxypropylmethylcellulose (HPMC). Dissolution mechanism analysis showed the release of pseudoephedrine was proportional to the square root of time, indicating that drug might be released from the layers by Fickian diffusion. The layer composed of pseudoephedrine/ethylcellulose/HPMC (110/30/155 mg), which had similar dissolution amounts of pseudoephedrine as the inner layer of a core tablet, was selected as the sustained-release layer. Furthermore, the dissolved amounts of drugs from the core and double-layer tablets had deviations of less than 5% against the average dissolved amounts of drugs at each time. There was no significant difference between the dissolved amounts of drugs from these tablets at each time in pH 1.2, 4.0, and 6.8 (P > .05). Our results suggest that this double-layer tablet was a dissolution equivalent to the core tablet.

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“…The eluent was monitored with an ultraviolet/visible (UV/ vis) detector set at 220 nm with a flow rate of 1.0 ml/ min (11)(12)(13). tion tester (DST-600, Fine Chemical, Seoul, Korea).…”

Section: Dissolution Testmentioning

confidence: 99%

Development of Terfenadine-Pseudoephedrine Double-Layer Tablet Dissolution-Equivalent to Core Tablet

Choi

Yong

Kim

2000

Drug Development and Industrial Pharmacy

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“…The popularity of capillary electrophoretic methods continues to expand as do the number articles that deal with either experimental ( − ) or validation ( − ) issues. Other technique-related reviews have been concerned with flow injection analysis (), ion-selective electrodes ( , ), ESI and MALDI mass spectrometry (), scanning probe microscopy (), thermoanalytical methods (), the analysis of antibiotics by LC/MS (), and the characterization of polymorphs and solvates by vibrational spectroscopy and nuclear magnetic resonance spectroscopy ().…”

Section: General Informationmentioning

confidence: 99%

Pharmaceuticals and Related Drugs

Gilpin

Pachla

1999

Anal. Chem.

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It does not cover biochemical or clinical aspects but deals only with unformulated and formulated products. The review continues to be divided into 11 major sections and in some cases subsection either by subtopic or by technique. Because of space limitations, a citation generally appears only in a single section and the articles selected do not represent an exhaustive review of the topics. GENERAL INFORMATIONExamples of comprehensive books and reviews that have been published in the last two years include the twenty-fifth volume of Analytical Profiles of Drug Substances and Excipients (1), Development and Validation of Analytical Methods (2), and Pharmaceuticals and Related Drugs (3). Three articles have appeared that deal with Assessment of Protein Drugs Obtained by Recombinant DNA Technology (4), Analytical Methods for Peptide Drugs Applicable to Process Control (5), and the purity, stability, and structural characteristics of insulin ( 6). Likewise, several other papers have addressed issues related to reference substances (7), validation (8), and content limits (9). Besides these, two books have been published that cover general aspects of the chromatographic analysis of pharmaceuticals (10, 11) and reviews have appeared that consider more specific chromatographic topics such as drug purity (12), quality control (13), and validation ( 14). The popularity of capillary electrophoretic methods continues to expand as do the number articles that deal with either experimental (15-17) or validation (18-20) issues. Other technique-related reviews have been concerned with flow injection analysis (21), ion-selective electrodes (22,23), ESI and MALDI mass spectrometry (24), scanning probe microscopy (25), thermoanalytical methods ( 26), the analysis of antibiotics by LC/MS (27), and the characterization of polymorphs and solvates by vibrational spectroscopy and nuclear magnetic resonance spectroscopy (28). ALKALOIDSSeparation-based methods continue to be the most widely used procedures for assaying alkaloids and their formulations. Two papers have been published that deal with optimization and validation of liquid chromatography (LC) procedures for major xanthine (A1) and opium (A2) alkaloids. Likewise, another account has appeared that describes the reversed-phase separation of morphine, codeine, thebaine, papaverine, and noscapine on a base-deactivated octadecyl column in combination with a gradient eluent containing 1-heptanesulfonic acid as the secondary modifier (A3). The morphine content in opium-ipecac tablets also has been evaluated by an alternate method which uses a phenyl bonded phase and a triethlyammonium phosphate buffer-methanol gradient as the eluent (A4). In both methods, each of the gradients takes ∼20 min to complete. A variety of other high-performance liquid chromatography (HPLC) assays have been reported during the last two years. Some examples of these include methods for theophylline and related compounds (A5, A6), atropine and atropine-like alkaloids (A7, A8), bromocriptine mesylate (A9), piloc...

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“…Several analytical techniques, including GC [15 -21] and HPLC [22,23] ion-pair HPLC [24 -26], and CE [27 -29], have been used for the determination of this drug in biological samples. However, GC methods involve a derivatization step and CE suffers from low sensitivity in terms of solute concentration compared to two other separation techniques.…”

Section: Introductionmentioning

confidence: 99%

Liquid–liquid–liquid microextraction followed by HPLC with UV detection for quantitation of ephedrine in urine

Bagheri¹,

Khalilian²,

Ahangar³

2008

J of Separation Science

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Liquid-liquid-liquid microextraction (LLLME) in combination with HPLC and UV detection has been used as a sensitive method for the determination of ephedrine in urine samples. Extraction process was performed in a homemade total glass vial without using a Teflon ring, usually employed. Ephedrine was first extracted from 3.5 mL of urine sample (pH 12) into a microfilm of toluene/benzene (50:50). The analyte was subsequently back extracted into an acidic microdrop solution (pH 2) suspended in the organic phase. The extract was then injected into the HPLC system directly. An enrichment factor of 137 along with a good sample clean-up was obtained under the optimized conditions. The calibration curve showed linearity in the range of 0.01-50 mg/L with regression coefficient corresponding to 0.998. The LODs and LOQs, based on a S/N of 3 and 10, were 5 and 10 microg/L, respectively. The method was eventually applied for the determination of ephedrine in urine sample after oral administration of 5 mg single dose of drug.

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Simultaneous Determination of Pseudoephidrine HC1 (PSE) and Terfanidine (TER) from Formulations by Reversed-Phase Ion Pair High-Performance Liquid Chromatography (RP-HPLC)

Cited by 8 publications

References 6 publications

Development of Terfenadine-Pseudoephedrine Double-Layer Tablet Dissolution-Equivalent to Core Tablet

Development of Terfenadine-Pseudoephedrine Double-Layer Tablet Dissolution-Equivalent to Core Tablet

Pharmaceuticals and Related Drugs

Liquid–liquid–liquid microextraction followed by HPLC with UV detection for quantitation of ephedrine in urine

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