Simultaneous determination of pseudoephedrine sulfate, dexbrompheniramine maleate and loratadine in pharmaceutical preparations using derivative spectrophotometry and ratio spectra derivative spectrophotometry

Onur, Feyyaz; Yücesoy, Cem; Dermiş, Saadet; Kartal, Murat; Kökdil, Gamze

doi:10.1016/s0039-9140(99)00256-8

Cited by 55 publications

(11 citation statements)

References 7 publications

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“…On the other hand, the British Pharmacopoeia (3) describes a potentiometic titration method, using perchloric acid as a titrant, for the determination of LRT in raw materials. A literature survey revealed that various methods have been published for the determination of LRT in pharmaceuticals and biological fluids, including spectrophotometry (4)(5)(6)(7)(8)(9)(10)(11), spectrofluorimetry (8), atomic absorption spectrometry (11), liquid chromatography (5,7,9,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), gas chromatography (23), densitometry (9), capillary electrophoresis (24) and polarography (25).…”

Section: Introductionmentioning

confidence: 99%

Stability‐indicating micelle‐enhanced spectrofluorimetric method for determination of loratadine and desloratadine in dosage forms

et al. 2011

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A highly sensitive and simple spectrofluorimetric method was developed for the determination of loratadine (LRT) and desloratadine (DSL) in their pharmaceutical formulations. The proposed method is based on investigation of the fluorescence spectral behaviour of LRT and DSL in a sodium dodecyl sulphate (SDS) micellar system. In aqueous solution of acetate buffer of pH 4.5, the fluorescence intensities of both LRT and DSL were greatly enhanced (240%) in the presence of SDS. The fluorescence intensity was measured at 438 nm after excitation at 290 nm for both drugs. The fluorescence-concentration plots were rectilinear over the range 0.05-2.0 µg/mL for both LRT and DSL, with lower detection limits of 5.13 × 10(-3) and 6.35 × 10(-3) µg/mL for LRT and DSL, respectively. The method was successfully applied to the analysis of the two drugs in their commercial tablets, capsules and syrups, and the results were in good agreement with those obtained with the official or comparison methods. The proposed method is specific for the determination of LRT in the presence of other co-formulated drugs, such as pseudoephedrine. The application of the proposed method was extended to stability studies of LRT and DSL after exposure to different forced degradation conditions, such as acidic, alkaline and oxidative conditions, according to ICH guidelines.

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Section: Introductionmentioning

confidence: 99%

Stability‐indicating micelle‐enhanced spectrofluorimetric method for determination of loratadine and desloratadine in dosage forms

et al. 2011

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“…Derivative techniques in the ultraviolet visible region are very useful when overlap or interference exists; they offer a powerful tool for both qualitative and quantitative analyses of mixtures [12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of Fe(III) and Al(III) by first-derivative spectrophotometry and partial least-squares (PLS-2) method – Application to post-haemodialysis fluids

Aguerssif

Benamor

Kachbi

et al. 2008

Journal of Trace Elements in Medicine and Biology

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“…Also, the presence of a lot of maxima and minima in ratio spectra derivative data was another advantage, since these wavelengths give an opportunity for the determination of these compounds in the presence of other active compounds and excipients that possibly interfered with the assay. 29 …”

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Recent Developments of Derivative Spectrophotometry and Their Analytical Applications

El‐Sayed

El-Salem

2005

ANAL. SCI.

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The zero-crossing derivative spectra method is the most common procedure for the simultaneous determination of binary mixtures of their overlapping spectra. As an example, the derivative spectra of binary mixtures of phospho-and silicomolybdenum blue are illustrated in Fig. 1. 23 By measuring the derivative values (heights h1 in Fig. 1) for mixtures of phosphate and silicate at 806 nm (zero-crossing wavelength of silicomolybdate complex), one can avoid the interference by silicate and the phosphate concentration can be determined. By measuring the derivative values (heights h2 in Fig. 1 Moreover, one disadvantage of the zero-crossing method is the necessity of selecting critical wavelengths for the measurements. This selection causes considerable loss of sensitivity and precision in case of binary mixtures. The so-called "ratio spectra derivative" permits the use of the wavelengths corresponding to maximum or minimum and also the use of the distance between consecutive maximum and minimum, thus avoiding these problems. 24 Salinas et al. 25 developed a derivative quotient spectra method with a standard divisor when the spectra of the components are overlapped. The method was based on dividing the spectrum for a mixture into the standard spectra for each of the analyses and driving the quotient to obtain a spectrum that is independent of the analyte concentration used as a divisor. The use of standardized spectra as divisors minimizes experimental errors and background noise. 26 An accurate choice of standard divisors and working wavelengths is fundamental for several reasons. 25,27,28 Easy measurements on separate peaks, higher values of the analytical signals and no need to work only at zero-crossing points (sometimes co-existing compounds have no maximum or minimum at these wavelengths) are advantages for ratio spectra derivative spectrophotometry in comparison with the zerocrossing derivative spectrophotometry. Also, the presence of a lot of maxima and minima in ratio spectra derivative data was another advantage, since these wavelengths give an opportunity for the determination of these compounds in the presence of other active compounds and excipients that possibly interfered with the assay. 29 2·1 Resolution of binary and ternary mixtures by applyingderivative ratio spectra (derivative quotient spectra) The absorption spectrum of a mixture of three compounds; A, B and C is determined by this equation:AM,λ i = εA,λ i CA + εB,λ i CB + εC,λ i CC (path-length is 1 cm)where, AM,λ i is the absorbance value of the mixture at wavelength λi, εA,λ i , εB,λ i and εC,λ i are the molar absorptivities of A, B and C at λi, CA, CP and CC are the molar concentrations of A, B and C, respectively. When we divide this spectrum by the spectrum of a standard solution of one of the components (e.g., A of concentration CA). That is bywe obtainThe first derivative of this spectrum ratio givesIf CC = 0, we have the binary mixture of A and B, and the spectrum in this case is:In Eq. (5) we can see that the derivative ratio spectrum of...

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Simultaneous determination of pseudoephedrine sulfate, dexbrompheniramine maleate and loratadine in pharmaceutical preparations using derivative spectrophotometry and ratio spectra derivative spectrophotometry

Cited by 55 publications

References 7 publications

Stability‐indicating micelle‐enhanced spectrofluorimetric method for determination of loratadine and desloratadine in dosage forms

Stability‐indicating micelle‐enhanced spectrofluorimetric method for determination of loratadine and desloratadine in dosage forms

Simultaneous determination of Fe(III) and Al(III) by first-derivative spectrophotometry and partial least-squares (PLS-2) method – Application to post-haemodialysis fluids

Recent Developments of Derivative Spectrophotometry and Their Analytical Applications

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