Simultaneous determination of propranolol and 4-hydroxy propranolol in human plasma by solid phase extraction and liquid chromatography/electrospray tandem mass spectrometry

Development of a MSFIA sample treatment system as front end of GC–MS for atenolol and propranolol determination in human plasma

“…As can be seen, the method has sufficient sensitivity for real drug level monitoring of ATN and PRO in human plasma. The values of the analytical parameters reported in Table 2 are comparable with those obtained by other reported methods [8,10,[12][13][14]18] making our approach competitive in terms of reproducibility and sensitivity. Table 3 presents a comparison of the developed MSFIA-SPE-MW/GC-MS results for on-line sample treatment and determination of ATN and PRO in human plasma with other methods (off line) found in the literature.…”

“…For this purpose, sensitive and accurate analytical methodologies for quantification of these compounds in biological fluids are required. Several methods have been described for the determination of ATN and PRO in human plasma using different techniques such as: immunoassays [4], spectrofluorimetry [5,6], electrochemistry [7] and liquid chromatography (LC) with photodiode array (UV), fluorescence detection (FLD) [8][9][10][11] and mass spectrometry (LC-MS) [12][13][14][15]. The latter have proved to be selective and sensitive methods for the simultaneous determination of BB in biological fluids.…”

Matrix-assisted laser desorption/ionization mass spectrometry for quantitative determination of β-blocker drugs in one-drop of human serum sample

“…The results are given in Table 1. The detailed procedure and experimental conditions for the determination of propranolol using SPE/ESI-MS have been described in the literature [28]. The sensitivity of the SPE/ESI-MS was better than DDSME/MALDI-MS, however, the sensitivity of the proposed method can be enhanced using high amount of sample volume (>30 L) for the extraction of drugs in DDSME.…”

Spectrophotometric Determination of Propranolol Hydrochloride and Metoprolol Tartrate in Pharmaceutical Dosage Forms, Spiked Water and Biological Fluids

“…Several methods have been reported for the determination of these drugs which includes spectrophotometry [10][11][12], spectrofluorimetry [13][14], gas chromatography-mass spectrometry (GC-MS) [15][16], high-performance liquid chromatography (HPLC) [17][18], liquid chromatography-mass spectrometry (LC-MS) [19][20][21], chemiluminescence [22][23], capillary electrophoresis [24][25] and voltammetry [26][27]. Spectrophotometric methods because of their inherent simplicity and rapidity of the procedure and low cost of the techniques find favour in most laboratories of limited means and consequently these methods continue to flourish.…”